4-Hydroxy-3-methoxyzimtsure
Ferulate · 4-HYDROXY-3-METHOXYCINNAMIC ACID · Ferulic · 3-METHOXY-4-HYDROXYCINNAMIC ACID · FERULLIC ACID · ferulaic acid · erulic Acid · Forulic acid
Identifikatoren & physikalische Daten
| CAS No. | 1135-24-6 |
|---|---|
| Summenformel | C10H10O4 |
| Durchschnittliche Molmasse | 194,18 g/mol |
| Monoisotopische Masse | 194,0579088 g/mol |
| SMILES | COc1cc(C=CC(=O)O)ccc1O |
| InChIKey | KSEBMYQBYZTDHS-UHFFFAOYSA-N |
| PubChem CID | 709 |
| ChEMBL | CHEMBL3185646 |
| DTXSID | DTXSID5040673 |
| Lokaler Name | 4-Hydroxy-3-methoxyzimtsure |
Chemische & physikalische Eigenschaften
| XLogP | 1,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 66,8 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 14 |
| Formalladung | 0 |
| Komplexität | 224 |
| LogP (Verteilungskoeffizient) | 1.87 |
| Schmelzpunkt | 168-172 °C(lit.) |
| Siedepunkt | 250.62°C (rough estimate) |
| Dichte | 1.316(20.0000℃) |
| Dampfdruck | 0Pa at 25℃ |
| Brechungsindex | 1.5168 (estimate) |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | DMSO (Slightly), Methanol (Slightly)soluble |
| pKa (Säurekonstante) | 4.58±0.10(Predicted) |
| Aggregatzustand | powder |
| Farbe | slightly yellow |
| Kosmetik-Inhaltsstoffe Funktionen | ANTIOXIDANTANTIMICROBIAL |
| InChIKey | KSEBMYQBYZTDHS-HWKANZROSA-N |
| LogP (Verteilungskoeffizient) | 1.51 |
| CAS Datenbank | 1135-24-6(CAS DataBase Reference) |
| NIST chemische Informationen | Cinnamic acid, 4-hydroxy-3-methoxy-(1135-24-6) |
| EPA chemische Informationen | Ferulic acid (1135-24-6) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29162090 |
| RTECS-Nr. | UD3365500 |
| R-Sätze (R) | 36/37/38 |
| Toxizität | mouse,LD,intraperitoneal,> 350mg/kg (350mg/kg),BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: ATAXIABEHAVIORAL: REGIDITY,Indian Journal of Pharmaceutical Sciences. Vol. 49, Pg. 77, 1987. |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36-37/39 |
| Gefahrenklasse | IRRITANT |
| Gefahrstoffdaten | 1135-24-6(Hazardous Substances Data) |
Anwendungen & Verwendung
Beschreibung
Ferulic acid is widely found in plants, especially in artichoke, eggplant and corn bran. In addition, it is also present in a variety of Chinese herbal medicines, such as angelica, dome, motherwort, snow ganoderma lucidum and so on.
History
Ferulic acid was first isolated from the medicinal plants ferulic in 1866. The biologi_x005fcal activity of ferulic acid was not revealed until 1957 when the pioneering study of Preziosi P in Italy showed for the first time the efficacy of ferulic acid in regulating blood lipids and diuretic . In 1979, Lin Mao and others isolated ferulic acid from the Chinese medicine angelica and reported that ferulic acid had the inhibitory effect on platelet aggregation . Since then, more and more medicinal efficacy of ferulic acid has gradually been recognized.
Verwenden
ferulic acid is a plant-derived anti-oxidant and free-radical scavenger, it protects the skin against uVB-induced redness. When incorporated into formulas with ascorbic acid and tocopherol, ferulic acid can improve their stability and double the photoprotection capacities offered by the formulation. In clinical studies, ferulic acid exhibits good permeation capacities through the stratum corneum, which can be attributed to its lipophilic properties.