Posatirelin
Grundinformationen
- CAS
78664-73-0- Standard-SMILES
CC(C)C[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)N1CCC[C@H]1C(N)=O- InChIKey
DPNGIIPSQYKWQA-AVGNSLFASA-N- Summenformel
- C17H28N4O4
- Durchschnittliche Molmasse
- 352,4 g/mol
- Monoisotopische Masse
- 352,21105539
Überblick
Posatirelin is an oligopeptide.
Namen und Bezeichner
- Bevorzugter Name
- Posatirelin
- IUPAC
- (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]-6-oxopiperidine-2-carboxamide
- Englischer Name
- Posatirelin
- Summenformel
- C17H28N4O4
- Molmasse
- 352.43
Namen und Synonyme
Posatirelin78664-73-0PosatirelineRGH-2202PosatirelinaPosatirelinumpAad-Leu-Pro-NH278U6302ARLDTXSID301318172L-Prolinamide, N-((6-oxo-2-piperidinyl)carbonyl)-L-leucyl-, (S)-L-6-ketopiperidine-2-carbonyl-leucyl-proline amidepyro-2-aminoadipoyl-leucyl-prolinamide
Weitere Namen anzeigen
BRN6006446BRN 6006446BRN-6006446N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2L-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-L-leucyl-N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide
RefChem:175327DTXCID601747960Posatirelin [INN](2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]-6-oxopiperidine-2-carboxamidePyladox(2S)-6-Oxo-2-piperidinecarbonyl-L-leucyl-L-prolinamidePosatireline [INN-French]Posatirelinum [INN-Latin]
Datenbank-Bezeichner
- CAS
78664-73-0
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -0,5
- Polarare Oberfläche (TPSA)
- 122 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 25
- Formalladung
- 0
- Komplexität
- 549
Physikochemische Eigenschaften
- Schmelzpunkt
- 214 · 214-216°
- Siedepunkt
- 739.6 · 739.6±60.0 °C(Predicted)
- Dichte
- 1.214 · 1.214±0.06 g/cm3(Predicted)
- pka
- 13.56 · 13.56±0.20(Predicted)
Chemie und Industrie
Anwendungen
BeschreibungPosatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated.
VerwendenPosatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter6 Anbieter
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
江苏洪珉药业有限公司18221292452 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海陶术生物科技股份有限公司
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