Flurithromycin
Grundinformationen
- CAS
82664-20-8- Standard-SMILES
CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@](C)(F)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O- InChIKey
XOEUHCONYHZURQ-HNUBZJOYSA-N- Summenformel
- C37H66FNO13
- Durchschnittliche Molmasse
- 751,9 g/mol
- Monoisotopische Masse
- 751,45181932
Namen und Bezeichner
- Bevorzugter Name
- Flurithromycin
- IUPAC
- (3R,4S,5S,6R,7R,9S,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-9-fluoro-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
- Englischer Name
- FLURITHROMYCIN
- Summenformel
- C37H66FNO13
- Molmasse
- 751.92
Namen und Synonyme
Flurithromycin82664-20-88-FluoroerythromycinFluritromicina(8S)-8-Fluoroerythromycin AFlurithromycineAntibiotic P 80206(8S)-8-FluoroerythromycinCl-932FlurithromycinumP-0501AP 80206
Weitere Namen anzeigen
p80206C1-932P-0501-Aantibioticp80206Huritromicina(sp)8-fluoro-erythromyci
56C9DTE69VCHEBI:131719DTXSID40905085(3R,4S,5S,6R,7R,9S,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-9-fluoro-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dioneflurythromycinflurythromycin Aantibiotic P-80206(3R,4S,5S,6R,7R,9S,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl)oxy-14-ethyl-9-fluoro-7,12,13-trihydroxy-4-((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
Datenbank-Bezeichner
- CAS
82664-20-8- PubChem CID
- 71260
- DTXSID
DTXSID40905085- ChEMBL
CHEMBL2106403- ChEBI
CHEBI:131719- UNII
- 56C9DTE69V
- EC Number
- 617-374-1
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,8
- Polarare Oberfläche (TPSA)
- 194 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 15
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 52
- Formalladung
- 0
- Komplexität
- 1.230
Physikochemische Eigenschaften
- Schmelzpunkt
- 139 °C · >139°C (dec.)
- Siedepunkt
- 814.6 · 814.6±65.0 °C(Predicted)
- Dichte
- 1.22 · 1.22±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C Freezer, Under inert atmosphere
- Löslichkeit
- Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 12.94 · 12.94±0.70(Predicted)
- Farbe
- White to Off-White
Sicherheit und Regulatorisches
Sicherheitsdaten
- risk_code
- 10
- hazard_code
- F
- safety_code
- 16
Chemie und Industrie
Pharmakologische Informationen
ATC Code
J - Antiinfectives for systemic use；J01 - Antibacterials for systemic use；J01F - Macrolides, lincosamides and streptogramins；J01FA - Macrolides；J01FA14 - Flurithromycin
QJ - Antiinfectives for systemic use；QJ01 - Antibacterials for systemic use；QJ01F - Macrolides, lincosamides and streptogramins；QJ01FA - Macrolides；QJ01FA14 - Flurithromycin
MeSH Pharmacological ClassificationCompounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Anwendungen
VerwendenA fluorinated derivative of Erythromycin (E649950). A macrolide antibiotic.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter10 Anbieter
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
Aladdin Scientific[email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
陕西缔都医药化工有限公司+86-29-87569262 +86-15003564040 · [email protected]
BOC Sciences16314854226 · [email protected]
艾吉析科技（上海）有限公司17721401538;17717235263 17721401538 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
深圳聚合生化科技有限公司+86-400-002-6226 · [email protected]
北京百灵威科技有限公司18210857532 18210857532 · [email protected]
Ergänzende Hinweise
DefinitionChEBI: An erythromycin derivative that is erythromycin A in which the hydrogen attached to the carbon at position 8 (alpha to the ketone carbonyl group) has been replaced by a fluorine. It has been used (generally as the corresponding monoethyl s ccinate ester) as an antibacterial drug.
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