N-Methyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-L-phenylalaninamide

BeschreibungKisspeptin-10, also called Metastin (45-54), is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.

VerwendenKisspeptin 10 (human) is a powerful and specific activator for AXOR12 and hOT7T175 receptors. The Kisspeptin 10 (human) amide has been utilized in studies involving progesterone release from MA-10 cells and in experiments to induce gonadal differentiation in clownfish.

VerwendenKisspeptin-10 (human), a member of the kisspeptin family, is a neuropeptide that regulates gonadotropin secretion. It has anti-angiogenic effects, a concentration-dependent inhibition of HUVEC proliferation and migration, and is highly expressed in the placenta, which may help to regulate angiogenesis in this tissue. Kisspeptin-10 (human) is currently undergoing clinical studies with insulin secretion in men. It is also a potential drug target for the treatment of infertility.