PUBCHEM_71433774
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Grundinformationen
- CAS
148554-65-8- Standard-SMILES
CO[C@@H](C[C@@H]1CC[C@@H](C)[C@](O)(C(=O)C(=O)N2CCCC[C@H]2C(=O)[O-])O1)C(C)=CC=CC=C[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)C(C)=C[C@@H](C)C(=O)C=C[C@H](C)C[C@@H]1CC[C@@H](O)[C@H](OC)C1.[Na+]- InChIKey
DNMSBJYMPJMFNS-PBCIJUQVSA-M- Summenformel
- C51H78NNaO13
- Durchschnittliche Molmasse
- 936,169 g/mol
- Monoisotopische Masse
- 935,53708584
Namen und Bezeichner
- Bevorzugter Name
- PUBCHEM_71433774
- IUPAC
- Sodium (2S)-1-{[(2R,3R,6S)-2-hydroxy-6-{(2S,9S,11R,13R,14R,17R,21R)-14-hydroxy-22-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl}-3-methyloxan-2-yl](oxo)acetyl}piperidine-2-carboxylate
- Englischer Name
- SECO RAPAMYCIN SODIUM SALT
- Summenformel
- C51H80NNaO13
- Molmasse
- 938.18
Namen und Synonyme
SecosirolimusSecorapamycin Na saltSECORAPAMYCIN A MONOSODIUMSECO RAPAMYCIN SODIUM SALTseco Rapamycin Sodium Salt, >85% By HPLC(19E/Z)-seco Rapamycin Sodium Salt (>80%)(19E/Z)-seco Rapamycin Sodium Salt, (>80% HPLC)(19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC)
Datenbank-Bezeichner
- CAS
148554-65-8- PubChem CID
- 71433774
- DTXSID
DTXSID70849549
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 120 · 120-122°C
- storage temp.
- -20 °C · Amber Vial, -20°C Freezer, Under Inert Atmosphere
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Pale Yellow to Yellow
- Stabilität
- Light Sensitive
Chemie und Industrie
Anwendungen
BeschreibungRapamycin is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration. It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay. Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells. Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species. While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.
VerwendenA metabolite of Sirolimus
Anbieter26 Anbieter
Suzhou ARTK Medchem Co., Ltd.+86-18168183658 · [email protected]
南京世洲生物科技有限公司025-025-85560043 17301488900 · [email protected]
Aladdin Scientific[email protected]
United Life Science020-82099279 18988968278 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
湖北广奥生物科技有限公司027-02702759223056 18162699093 · [email protected]
杭州东帆化学有限公司86-0571-85151182
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
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