Grundinformationen
- CAS
1264-72-8- Standard-SMILES
CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
ZESIAEVDVPWEKB-ORCFLVBFSA-N- Summenformel
- C105H206N32O32S2
- Durchschnittliche Molmasse
- 2.493,1 g/mol
- Monoisotopische Masse
- 2.491,4917349
Überblick
Colistin Sulfate is cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally. (Medical Dictionary Online)
Namen und Bezeichner
- Bevorzugter Name
- Colistin Sulfate
- IUPAC
- N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxybutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide;N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxybutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
- Lokaler Name
- Colistin, Sulfat (Salz)
- Englischer Name
- Colistin sulfate
- Summenformel
- 2(C52H98N16O13).5(H2SO4)
- Molmasse
- 2801.27
Namen und Synonyme
BelcomycineCantrexColimycin sulphateColistins sulphateSulfate, ColistinRefChem:54884215-034-3N-(4-amino-1-(1-(4-amino-1-oxo-1-(3,12,23-tris(2-aminoethyl)-20-(1-hydroxyethyl)-6,9-diisobutyl-2,5,8,11,14,19,22-heptaoxo-1,4,7,10,13,18-hexaazacyclotricosan-15-ylamino)butan-2-ylamino)-3-hydroxybutan-2-ylamino)-1-oxobutan-2-yl)-N,5-dimethylheptanamide;sulfuric acid1264-72-8BelcomycinColimycin sulfateColistin Sulfate
Weitere Namen anzeigen
POLYMYXIN ECOLISTINE SULPHATECOLISTINE SULFATECoLCOLISTIN SULFATE SALTColomyciistin suL
Colistin sulphateColistin, sulfate (salt)Colistins sulfateColy-Mycin SDTXSID3045352KannasynKantrimNSC-759273
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 1.110 Ų
- H-Brücken-Donoren
- 40
- H-Brücken-Akzeptoren
- 44
- Frei drehbare Bindungen
- 59
- Schwere Atome
- 171
- Formalladung
- 0
- Komplexität
- 4.040
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 200 · 200-220°C
- storage temp.
- 2 · Inert atmosphere,2-8°C
- Löslichkeit
- 2 O: · H2O: soluble50mg/mL
- Aggregatzustand
- powder
- Farbe
- White to off-white
- PH
- 4 · 4.0~6.0(10g/l, 25℃)
- Wasserlöslichkeit
- Soluble in water
- Merck
- 14 · 14,2479
- Specific Activity
- 19 · ≥19,000IU/mg
- Major Application
- USP Biologicspharmaceutical (small molecule)
- InChIKey
- VEXVWZFRWNZWJX-NBKAJXASSA-N
- SMILES
- C(NC(C(=O)NC(C(=O)NC(C(=O)NC1CCNC(=O)C(C(O)C)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O)CCN)C(O)C)CCN)(=O)CCCC(C)CC.S(O)(O)(=O)=O
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (95.2%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 124 reports by companies from 4 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory InformationColistin, sulfate (salt): Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Colistin, sulfate (salt): Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (95.2%)
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 29419000
- RTECS-Nr.
- TR1500000
- risk_code
- 25
- hazard_code
- T
- safety_code
- 45
- hazard_class
- 6.1(b)
- packing_group
- III
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Acute Tox. 3 Oral
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Verwendung und Herstellung
Use ClassificationVeterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes
Anwendungen
VerwendenColistin sulfate A Polymyxin potent antibiotic and apoptosis inducer. This compound induces apoptosis through interaction with the cytoplasmic membrane. Colistin is a key microbiological component in Colistin Oxolinic Acid Blood Agar utilized in the cultivation of Aminobacter aminovorans, Bacillus species, Hyphomicrobium species and Methylobacterium species. It is also a critical component is VCN Inhibitor & VCNT Inhibitor growth media used in the isolation of Neisseria species.
Vor- und nachgelagerte Produkte
Nachgelagerte Produkte
Anbieter100 Anbieter
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
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