1405-37-4C[C@@H]1NC(=O)[C@@H](N)CNC(=O)[C@H](C2CCN=C(N)N2)NC(=O)/C(=C/NC(N)=O)NC(=O)[C@H](CNC(=O)CC(N)CCCN)NC1=O.NCCCC(N)CC(=O)NC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC(=O)[C@H](C2CCN=C(N)N2)NC(=O)/C(=C/NC(N)=O)NC1=O.O=S(=O)(O)O.O=S(=O)(O)OTUATYNXRYJTQTQ-BVRBKCERSA-NCapreomycin Sulfate is a calcium salt form of capreomycin, a cyclic polypeptide isolated from Streptomyces capreolus with antitubercular activity. Capreomycin acts by blocking bacterial ribosomal translocation.
1405-37-4CHEMBL2218913FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
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Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Induced Liver Injury Rank (DILIrank 2.0)
Capreomycin sulfate
Ambiguous-DILI-concern
3
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
Substances obtained from various species of microorganisms that are, alone or in combination with other agents, of use in treating various forms of tuberculosis; most of these agents are merely bacteriostatic, induce resistance in the organisms, and may be toxic.
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Substances that inhibit the growth or reproduction of BACTERIA.
BeschreibungCapreomycin is a polypeptide antibiotic first isolated from S. capreolus. It is cytotoxic to M. tuberculosis (MIC = 10 μg/ml). Capreomycin is more effective against M. tuberculosis when combined with aminoglycoside antibiotics.
Verwendenantibacterial, tuberculostatic
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