PUBCHEM_71571504
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Grundinformationen
- CAS
129741-57-7- Standard-SMILES
C=C(C)C1CCC2(C(=O)O[C@@H]3OC(CO[C@@H]4O[C@H](CO)[C@@H](O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)CC[C@@]3(C)[C@]4(C)CC[C@H]5[C@](C)(CO)[C@@H](OC6OC[C@H](O)[C@H](O)[C@H]6O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)CC[C@]5(C)[C@H]4CC[C@]3(C)[C@@H]12- InChIKey
XLBRLNYIBZWSAV-ZCSAOVMRSA-N- Summenformel
- C60H98O26
- Durchschnittliche Molmasse
- 1.235,418 g/mol
- Monoisotopische Masse
- 1.234,63463326
Namen und Bezeichner
- Bevorzugter Name
- PUBCHEM_71571504
- IUPAC
- 6-Deoxy-alpha-L-mannopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-(5xi)-1-O-[(17xi)-3beta-{[2-O-(6-deoxy-alpha-L-mannopyranosyl)-L-arabinopyranosyl]oxy}-23-hydroxy-13-methyl-28-oxolup-20(29)-en-28-yl]-beta-D-xylo-hexopyranose
- Englischer Name
- PULCHINENOSIDE B4
- Summenformel
- C59H96O26
- Molmasse
- 1221.38
Namen und Synonyme
Anemoside B4Pulchinenoside CAnemoside B4 Pulchinenoside B4Chinensioside APULCHINENOSIDE B4Pulsatilla saponin B4Pulchinenoside B4 CRSAnemosideB4 129741-57-7Pulchinenoside C (Standard)Pulchinenoside C (Anemoside B4)
Datenbank-Bezeichner
- CAS
129741-57-7- PubChem CID
- 71571504
- DTXSID
DTXSID00856145
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 208 · 208-215℃
- Dichte
- 1.48 · 1.48
- Löslichkeit
- 125 mg/mL · DMSO : 125 mg/mL (102.34 mM; Need ultrasonic)
- Aggregatzustand
- Powder
- pka
- 12.5 · 12.50±0.70(Predicted)
- Farbe
- White to light yellow
- Major Application
- pharmaceutical
- InChIKey
- OUHBKBTZUPLIIA-UFEMLMIJNA-N
Chemie und Industrie
Anwendungen
BeschreibungPulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities. It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM. Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner. Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.
VerwendenPulchinenoside C is a triterpenoid saponin extract which acts as a minor molluscicidal agent in addition to tumor necrosis factor-α secretion inhibition. Anti-inflammatory.
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上海如吉生物科技发展有限公司
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