DOTMP Ho-166
Grundinformationen
- CAS
633308-23-3- Standard-SMILES
O=P([O-])(O)CN1CCN(CP(=O)(O)O)CCN(CP(=O)([O-])O)CCN(CP(=O)(O)O)CC1.[166Ho]- InChIKey
PRYANEHDLFDXAN-IEOVAKBOSA-L- Summenformel
- C12H30HoN4O12P4-2
- Durchschnittliche Molmasse
- 712,21 g/mol
- Monoisotopische Masse
- 712,013362
Überblick
DOTMP HO-166 is used in skeletal targeted radiotherapy (STR). SRT is designed to be used in combination with high-dose chemotherapy producing a direct therapeutic effect on the tumor sites in the bone plus a general bone-marrow effect to destroy myeloma cells in the bone marrow. It is an experimental therapy that is being developed by NeoRx Corporation.
Namen und Bezeichner
- Bevorzugter Name
- DOTMP Ho-166
- IUPAC
- holmium-166;hydroxy-[[7-[[hydroxy(oxido)phosphoryl]methyl]-4,10-bis(phosphonomethyl)-1,4,7,10-tetrazacyclododec-1-yl]methyl]phosphinate
Namen und Synonyme
DOTMP Ho-166Holmium Ho-166 dotmp166Ho-DOTMP9F972459OC633308-23-3lambda2-(166Ho)holmium(2+) ion ((4,7,10-tris(phosphonomethyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl)phosphonatelambda2-(166Ho)holmium(2+) ion {[4,7,10-tris(phosphonomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]methyl}phosphonateHolmium-166 DOTMPRefChem:590381Chelating agent delivering Holmium-166166HO-1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAMETHYLENE-PHOSPHONIC ACIDUNII-9F972459OC
Weitere Namen anzeigen
166Ho-1,4,7,10-tetraazacyclododecane-1,4,7,10- tetramethylene-phosphonic acidSCHEMBL30279617Q27272479
Datenbank-Bezeichner
- CAS
633308-23-3- PubChem CID
- 71587775
- UNII
- 9F972459OC
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 249 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 16
- Frei drehbare Bindungen
- 8
- Schwere Atome
- 33
- Formalladung
- -2
- Komplexität
- 693
Chemie und Industrie
Pharmakologische Informationen
Mechanism of Action
There are two important components of 166Ho-DOTMP. The first is DOTMP, a chemical that collects in bones. The other component of 166Ho-DOTMP is radioactive holmium, abbreviated 166Ho. 166Ho is a radioactive particle that is bound to the DOTMP. Certain types of cells in the body, such as many cancer cells, are sensitive to radioactivity and can be killed if they are close to a radioactive particle such as 166Ho. These properties make 166Ho-DOTMP a potentially useful drug for the treatment of cancers in the bone. When the drug collects in the bone, it will expose cells there to 166Ho, killing cancer cells.
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…