Tunlametinib
Grundinformationen
- CAS
1801756-06-8- Standard-SMILES
O=C(NOCCO)c1cc2scnc2c(F)c1Nc1ccc(I)cc1F- InChIKey
UFZJUVFSSINETF-UHFFFAOYSA-N- Summenformel
- C16H12F2IN3O3S
- Durchschnittliche Molmasse
- 491,3 g/mol
- Monoisotopische Masse
- 490,96122
Überblick
Tunlametinib is an orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MAP2K, MAPK/ERK kinase, or MEK), with potential antineoplastic activity. Upon administration, tunlametinib selectively binds to and inhibits the activity of MEK, preventing the activation of MEK-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK, a threonine/tyrosine kinase, plays a key role in the activation of the RAS/RAF/MEK/ERK pathway that regulates cell growth. This pathway is often dysregulated in a variety of tumor cell types through BRAF, KRAS and NRAS mutations.
Namen und Bezeichner
- Bevorzugter Name
- Tunlametinib
- IUPAC
- 4-fluoro-5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,3-benzothiazole-6-carboxamide
- Englischer Name
- Tunlametinib
- Summenformel
- C16H12F2IN3O3S
- Molmasse
- 491.25
Namen und Synonyme
tunlametinib1801756-06-8Tunlametinib [INN]IF25NR1PV3HL085HL-0854-fluoro-5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,3-benzothiazole-6-carboxamideHl 085Tunlametinib (INN)4-Fluoro-5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-6-benzothiazolecarboxamide6-Benzothiazolecarboxamide, 4-fluoro-5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-Example 9 [WO2013107283A1]
Weitere Namen anzeigen
Tunlametinib（HL-085）6-Benzothiazolecarboxamide, 4-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-4-Fluoro-5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzo[d]thiazole-6-carboxamide
4-Fluoro-5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-6-benzothiazolecarboxamideExample 9 (WO2013107283A1)RefChem:192552MEK Inhibitor HL-085HL-085 [WHO-DD]UNII-IF25NR1PV34-fluoro-5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)benzo[d]thiazole-6-carboxamideKolupin (China)
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 4
- Polarare Oberfläche (TPSA)
- 112 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 26
- Formalladung
- 0
- Komplexität
- 496
Physikochemische Eigenschaften
- Dichte
- 1.864 · 1.864±0.06 g/cm3(Predicted)
- Aggregatzustand
- Solid
- pka
- 14.17 · 14.17±0.10(Predicted)
- Farbe
- Off-white to light yellow
Chemie und Industrie
Pharmakologische Informationen
ATC Code
L - Antineoplastic and immunomodulating agents
QL - Antineoplastic and immunomodulating agents
Anwendungen
BeschreibungTunlametinib is a selective mitogen-activated protein kinase 1 and kinase 2 (MEK1/2) kinase inhibitor, which plays an antitumor role by inhibiting the activity of MEK1/2 kinase. The marketing of this drug provides new treatment options for patients with advanced NRAS-mutant melanoma who fail anti- PD-1/PD-L1 therapy.
Anbieter13 Anbieter
天津欣康佑生物科技有限公司19922659386 19922659386 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
学研惠（武汉）科技有限公司15727060112 · [email protected]
武汉永璨生物科技有限公司17702719238 · [email protected]
苏州凯若利新材料科技有限公司+86-51266834346 +86-17751128648 · [email protected]
台州南峰药物研究所[email protected] 13127117265 · [email protected]
苏州凯若利新材料科技有限公司0512-66834346 17751187418 · [email protected]
韶远科技（上海）有限公司
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