Lufenuron
Grundinformationen
- CAS
103055-07-8- Standard-SMILES
O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(OC(F)(F)C(F)C(F)(F)F)cc1Cl- InChIKey
PWPJGUXAGUPAHP-UHFFFAOYSA-N- Summenformel
- C17H8Cl2F8N2O3
- Durchschnittliche Molmasse
- 511,1 g/mol
- Monoisotopische Masse
- 509,9784228
Überblick
Lufenuron is a dichlorobenzene, an aromatic ether, an organofluorine compound, a benzoylurea insecticide and a N-acylurea.
Namen und Bezeichner
- Bevorzugter Name
- Lufenuron
- IUPAC
- N-[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluorobenzamide
- Englischer Name
- Lufenuron
- Summenformel
- C17H8Cl2F8N2O3
- Molmasse
- 511.15
Namen und Synonyme
Lufenuron103055-07-8FluphenacurLufenuroneLufenuronumProgram flavor tabsPROGRAMDTXSID5034357N-((2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)carbamoyl)-2,6-difluorobenzamide1-(2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)-3-(2,6-difluorobenzoyl)ureaProgram SuspensionCGA-184699
Weitere Namen anzeigen
Lufenuron for peak identificationLufenuron 97%Lufenuron@1000 μg/mL in AcetoneLufenurincga-184,699
Program Cat Flavor TabsNSC-759097N-[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluorobenzamide1R754M4918DTXCID3014357CHEBI:39384Program 6 Month Injectable for CatsN-{[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl}-2,6-difluorobenzamide
Datenbank-Bezeichner
- CAS
103055-07-8、130841-22-4、130841-26-8
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 6,4
- Polarare Oberfläche (TPSA)
- 67,4 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 11
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 32
- Formalladung
- 0
- Komplexität
- 677
Experimentelle und physikochemische Eigenschaften
PFAS
PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008
PFAS -> OECD Category
PFAS -> Other/unspecified
PFAS -> Other/unspecified
Pesticides
Insecticides
Active substance -> EU Pesticides database: Not approved
Environmental transformation -> Pesticides (parent, predecessor)
Veterinary substances, Acaricides, Insecticides
Pesticide (Lufenuron) -> USDA PDB
LogP5.12
Animal DrugsFDA approved animal drugs -> Active ingredient
Collision Cross Section
205.4 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID5034357]
198.53 Ų [M+H]+ [CCS Type: TW]
209.11 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
196.94 Ų [M+H]+
Physikochemische Eigenschaften
- Schmelzpunkt
- 174.1 ° · 174.1°
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement)
Danger
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)
Gefahrenhinweise
Regulatory Information
Commission Regulation (EC) No 1490/2002
2009/77/EC, Reg. (EU) 2022/801, Reg. (EU) No 540/2011
REACH registered substance: N-[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)-phenyl-aminocarbonyl]-2,6-difluorobenzamide (EC: 410-690-9)
Lufenuron: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and Categories
Skin Sens. 1 (100%)
Skin sensitisation - category 1
Reproductive toxicity - Category 2
Skin sensitization - Category 1B
Skin Sens. 1
Sicherheitsdaten
- wgk
- 2
- ridadr
- 3077
- hs_code
- 29242990
- risk_code
- 43-50/53
- Toxizität
- LD50 in rats (mg/kg): >2000 orally; LC50 in rats (mg/m3): >2350 (Buholzer)
- hazard_code
- Xi;N,N,Xi
- safety_code
Chemie und Industrie
Pharmakologische Informationen
ATC CodeQP - Antiparasitic products, insecticides and repellents
MeSH Pharmacological ClassificationPesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.
Verwendung und Herstellung
Use Classification
Veterinary Drug -> INSECTICIDE; Veterinary Drug -> -> JECFA Functional Classes
Environmental transformation -> Pesticides (parent, predecessor)
Veterinary substances, Acaricides, Insecticides
PFAS (per- and polyfluoroalkyl substances) -> OECD Category
Anwendungen
BeschreibungLufenuron is an insect development inhibitor of the benzoylphenyl urea class. It demonstrates activity against fleas that have fed on treated cats and dogs and become exposed to lufenuron in the host’s blood. Lufenuron also has activity by virtue of its presence in adult flea feces, leading to its ingestion by flea larvae. Both activities result in the production of eggs that are unable to hatch, causing significant reductions in flea larvae populations. The lipophilicity of lufenuron leads to its deposition in adipose tissues of animals from where it is slowly released into the bloodstream. This permits effective blood concentrations to be maintained throughout the recommended oral dosing interval of 1 month.
VerwendenLufenuron is used for the control of Lepidoptera and Coleoptera larvae on cotton, maize and vegetables, and of citrus whitefly and rust mites on citrus fruit. It is also used to control fleas on pets and cockroaches in houses.
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