HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Alacepril
du1219 · Alapri · cetapril · Cetapfil · ALACEPRIL · Alacepril API · (s)-l-phenylalanin · Alacepril USP/EP/BP
Identifikatoren & physikalische Daten
| CAS No. | 74258-86-9 |
|---|---|
| Summenformel | C20H26N2O5S |
| Durchschnittliche Molmasse | 406,5 g/mol |
| Monoisotopische Masse | 406,15624293 g/mol |
| SMILES | CC(=O)SC[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| InChIKey | FHHHOYXPRDYHEZ-COXVUDFISA-N |
| PubChem CID | 71992 |
| ChEMBL | CHEMBL2103775 |
| ChEBI | CHEBI:31182 |
| DTXSID | DTXSID3048576 |
Chemische & physikalische Eigenschaften
| XLogP | 2,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 129 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 6 |
| Frei drehbare Bindungen | 9 |
| Schwere Atome | 28 |
| Formalladung | 0 |
| Komplexität | 591 |
| Schmelzpunkt | 155-156° |
| Siedepunkt | 679.1±55.0 °C(Predicted) |
| Dichte | 1.281±0.06 g/cm3(Predicted) |
| Lagerbedingungen | 2-8°C |
| pKa (Säurekonstante) | 3.56±0.10(Predicted) |
| Aggregatzustand | Solid |
| Farbe | White to off-white |
| CAS Datenbank | 74258-86-9(CAS DataBase Reference) |
Sicherheit & Vorschriften
| Toxizität | LD50 in rats, mice (mg/kg): >5000, >5000 orally>3000, >3000 s.c.~2000, ~3000 i.p. (Iida, pp 7033-40) |
|---|
Anwendungen & Verwendung
Beschreibung
Alacepril is an angiotensin-converting enzyme (ACE) inhibitor useful in the treatment of essential and renal hypertension. Compared with captopril, alacepril is a weaker ACE inhibitor in vino, yet clinically it has a longer duration of action and appears to be more active due to an added component of norepinephrine antagonism.