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Panipenem
PAPM · cs533 · PANIPENEM · Panipenan · Panipenemum · carbapenemrs-533 · FAROPENEM, 90.0% · Panipenem USP/EP/BP
Identifikatoren & physikalische Daten
| CAS No. | 87726-17-8 |
|---|---|
| Summenformel | C15H21N3O4S |
| Durchschnittliche Molmasse | 339,4 g/mol |
| Monoisotopische Masse | 339,12527733 g/mol |
| SMILES | CC(=N)N1CC[C@H](SC2=C(C(=O)O)N3C(=O)[C@H]([C@@H](C)O)[C@H]3C2)C1 |
| InChIKey | TYMABNNERDVXID-DLYFRVTGSA-N |
| PubChem CID | 72015 |
| ChEMBL | CHEMBL339323 |
| ChEBI | CHEBI:7911 |
| EC No. | 841-739-6 |
| DTXSID | DTXSID20868982 |
Chemische & physikalische Eigenschaften
| XLogP | 0 |
|---|---|
| Polarare Oberfläche (TPSA) | 130 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 6 |
| Frei drehbare Bindungen | 5 |
| Schwere Atome | 23 |
| Formalladung | 0 |
| Komplexität | 606 |
| Arzneimittel | Pharmaceuticals -> Antibiotics |
| Schmelzpunkt | 198-200° (dec) |
| Siedepunkt | 555.5±60.0 °C(Predicted) |
| Dichte | 1.62±0.1 g/cm3(Predicted) |
| Lagerbedingungen | Amber Vial, Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Löslichkeit | DMSO (Slightly), Methanol (Very Slightly), Water (Slightly) |
| pKa (Säurekonstante) | 4.30±0.40(Predicted) |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
| Stabilität | Hygroscopic, Light Sensitive |
| CAS Datenbank | 87726-17-8(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Toxizität | Approx LD50 in male, female mice (mg/kg): 1700-2200, 1300-1700 i.v. (Kimura) |
Anwendungen & Verwendung
Verwenden
Panipenem is a broad spectrum carbapenem antibacterial and antimicrobial agent working against Gram-negative and Gram-positive organisms.