Perindoprilat

Perindopril EP IMpurity B · Perindopril Impurity B · (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]propanoyl]octahydro-1H-indole-2-carboxylicacid(perindoprilat) · S-9780 · Diacid form · PERINDOPRILAT · Perindoprilate · Perindoprilat ,95%

https://huagongshe.com/de/chemical/72022

Identifikatoren & physikalische Daten

CAS No.	95153-31-4
Summenformel	C17H28N2O5
Durchschnittliche Molmasse	340,4 g/mol
Monoisotopische Masse	340,199822 g/mol
SMILES	CCC[C@H](N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C(=O)O
InChIKey	ODAIHABQVKJNIY-PEDHHIEDSA-N
PubChem CID	72022
ChEMBL	CHEMBL1201368
ChEBI	CHEBI:132041
EC No.	110-978-1
DTXSID	DTXSID90869249

Chemische & physikalische Eigenschaften

XLogP	0,2
Polarare Oberfläche (TPSA)	107
H-Brücken-Donoren	3
H-Brücken-Akzeptoren	6
Frei drehbare Bindungen	7
Schwere Atome	24
Formalladung	0
Komplexität	495
Arzneimittel	Pharmaceuticals -> Metabolite of Perindopril
Schmelzpunkt	153-155°C
Siedepunkt	568.1±45.0 °C(Predicted)
Dichte	1.222±0.06 g/cm3(Predicted)
Lagerbedingungen	-20°C Freezer
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pKa (Säurekonstante)	2.27±0.20(Predicted)
Farbe	White to Pale Beige
Stabilität	Hygroscopic
CAS Datenbank	95153-31-4

Sicherheit & Vorschriften

GHS-Einstufung	WarningH361d (100%): Suspected of damaging the unborn child [Warning Reproductive toxicity]P203, P280, P318, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard Classes and Categories	Repr. 2 (100%)
Zollcode	2933999552

Anwendungen & Verwendung

Verwenden

Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension. Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.[Cayman Chemical]