HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Fomidacillin
Imipenem 16 · Fomidacillin · Formidacillin · (2S,5R,6R)-6-[[(2R)-2-(3,4-dihydroxyphenyl)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]acetyl]amino]-6-formamido-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid · 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-(3,4-dihydroxyphenyl)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]acetyl]amino]-6-(formylamino)-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
Identifikatoren & physikalische Daten
| CAS No. | 98048-07-8 |
|---|---|
| Summenformel | C24H28N6O10S |
| Durchschnittliche Molmasse | 592,6 g/mol |
| Monoisotopische Masse | 592,15876228 g/mol |
| SMILES | CCN1CCN(C(=O)N[C@@H](C(=O)N[C@]2(NC=O)C(=O)N3[C@@H](C(=O)O)C(C)(C)S[C@@H]32)c2ccc(O)c(O)c2)C(=O)C1=O |
| InChIKey | BLHZPPIRNRDRSC-HSDAMQNGSA-N |
| PubChem CID | 72025 |
| ChEMBL | CHEMBL2105850 |
| DTXSID | DTXSID301024779 |
Chemische & physikalische Eigenschaften
| XLogP | 0,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 251 |
| H-Brücken-Donoren | 6 |
| H-Brücken-Akzeptoren | 11 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 41 |
| Formalladung | 0 |
| Komplexität | 1.170 |
| Arzneimittel | Pharmaceuticals -> Antibiotics |
| Dichte | 1.67±0.1 g/cm3(Predicted) |
| pKa (Säurekonstante) | 2.45±0.50(Predicted) |
Anwendungen & Verwendung
Verwenden
Fomidacillin is β-lactamase stable Penicillin derivative with antibacterial activity comparable to Imipenem (I465200), and Ceftazidime (C244100) antibiotics. Fomidacillin is also an analogue of Piperacillin (P479950), which is a broad spectrum semi-synthetic antibiotic.