HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Ethoxyanilin
2-ETHOXYANILINE · O-ETHOXYANILINE · o- · Hlt · SUBgt · /SUBgt · AKOS 91146 · Catechol-d4
Identifikatoren & physikalische Daten
| CAS No. | 1321-31-9 |
|---|---|
| Summenformel | C8H11NO |
| Durchschnittliche Molmasse | 137,18 g/mol |
| Monoisotopische Masse | 137,08406397 g/mol |
| SMILES | CCOc1ccccc1N |
| InChIKey | ULHFFAFDSSHFDA-UHFFFAOYSA-N |
| PubChem CID | 7203 |
| ChEMBL | CHEMBL1525301 |
| ChEBI | CHEBI:190954 |
| EC No. | 202-356-4 |
| DTXSID | DTXSID5025863 |
| Lokaler Name | 2-Ethoxyanilin |
Chemische & physikalische Eigenschaften
| XLogP | 1,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 35,3 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 10 |
| Formalladung | 0 |
| Komplexität | 95 |
| Dichte | 1.044 at 69.4 °F (NTP, 1992) - Denser than waterwill sink1.051 g/mL at 25 °C(lit.) |
| Löslichkeit | 5 to 10 mg/mL at 76.1 °F (NTP, 1992)soluble in alcohol and ether.0.5-1.0 g/100 mL at 24.5 ºC |
| Flammpunkt | greater than 200 °F (NTP, 1992)177 °F |
| Siedepunkt | 444 to 450 °F at 760 mmHg (NTP, 1992)231-233 °C(lit.) |
| Schmelzpunkt | less than -4 °F (NTP, 1992)-20 °C |
| Dampfdruck | 1 mmHg at 152.6 °F25 mmHg at 271 °F (NTP, 1992)0.02 [mmHg]1 mm Hg ( 67 °C) |
| Physical Description | Reddish brown oily liquid. (NTP, 1992)Rapidly turned brown by light and air[Merck Index] Reddish-brown oily liquid[CAMEO] Clear dark red liquid[Sigma-Aldrich MSDS] |
| Kovats Retention Index | 1206.8 |
| Brechungsindex | n20/D 1.555(lit.) |
| Lagerbedingungen | Store at +15°C to +25°C. |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | 4.43(at 28℃) |
| Farbe | Deep red |
| Merck | 14,7227 |
| BRN | 637069 |
| InChI | 1S/C8H11NO/c1-2-10-8-6-4-3-5-7(8)9/h3-6H,2,9H2,1H3 |
| InChIKey | ULHFFAFDSSHFDA-UHFFFAOYSA-N |
| SMILES | CCOc1ccccc1N |
| CAS Datenbank | 94-70-2(CAS DataBase Reference) |
| NIST chemische Informationen | Benzenamine, 2-ethoxy-(94-70-2) |
| EPA chemische Informationen | o-Phenetidine (94-70-2) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]H311: Toxic in contact with skin [Danger Acute toxicity, dermal]H331: Toxic if inhaled [Danger Acute toxicity, inhalation]H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]P260, P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P319, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement) |
|---|---|
| Regulatorische Informationen | Chemical: Benzenamine, 2-ethoxy-Status: Active Update: 08-05-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/100832-Aminophenetole: Does not have an individual approval but may be used under an appropriate group standard |
| DOT-Kennzeichnung | Poison |
| Brandgefahren | This chemical is probably combustible. (NTP, 1992) |
| Gesundheitsgefahren | SYMPTOMS: Exposure to this compound may cause cyanosis, hypothermia, headache, drowsiness, vomiting, irritation of the alimentary tract and nephritis.ACUTE/CHRONIC HAZARDS: This compound and its vapors may cause irritation of the eyes, skin and mucous membranes. (NTP, 1992) |
| Gefahrenübersicht | Toxic (vapor is also hazardous)Can be absorbed through skin[Merck Index] Liquid or vapor may cause skin, eye, and mucous membrane irritationOther symptoms may include cyanosis, headache, drowsiness, vomiting, alimentary tract irritation, and nephritis[NTP] May induce methemoglobinemiaHarmful by ingestionToxic by inhalation and skin absorption[Sigma-Aldrich MSDS] See p-Phenetidine. |
| Reaktive Gruppe | Amines, Aromatic |
| Reactivity Profile | O-PHENETIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. |
| Air and Water Reactions | This compound is very sensitive to exposure to light and air. (NTP, 1992). Slightly soluble in water. |
| Hazard Classes and Categories | Acute Tox. 3 (97.9%)Acute Tox. 3 (100%)STOT RE 2 (96.8%)Acute toxicity - category 3Specific target organ toxicity (repeated exposure) - category 2Acute Tox. 3 *STOT RE 2 * |
| Brandbekämpfung | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992) |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992) |
| Isolation and Evacuation | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directionsalso, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024) |
| Personal Protective Equipment (PPE) | RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992) |
| Unerwünschte Wirkungen | Methemoglobinemia - The presence of increased methemoglobin in the bloodthe compound is classified as secondary toxic effect |
| F | 8-10-23 |
| Wassergefährdungsklasse (WGK) | 2 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 2311 6.1/PG 3 |
| Zollcode | 29222200 |
| RTECS-Nr. | SI6465300 |
| R-Sätze (R) | 23/24/25-33 |
| Toxizität | LD50 orl-rbt: 600 mg/kg NYKZAU 52,215,56 |
| Gefahrensymbole | T,Xi |
| hazard_note | Irritant |
| Sicherheitshinweise (S) | 28-36/37-45-28A |
| Gefahrenklasse | 6.1Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralSTOT RE 2 |
| Verpackungsgruppe | III |
| Lagerklasse | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
| Selbstentzündungstemperatur | 425 °C |
Anwendungen & Verwendung
Verwenden
manufacture of dyes.
Herstellung & Synthese
synthetische
o-Phenetidine is produced from 2- ethoxynitrobenzene by reduction with iron or by catalytic hydrogenation in the presence of precious-metal catalysts or Raney nickel.