HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Aureobasidin-A
aureobasidin A · LY-295337 · Basifungin · Brazil Fenjing · Basifungin(AbA) · Jin Basidiomycin A · Aureobasidin A (AbA) · Aureobasidin A (9CI)
Identifikatoren & physikalische Daten
| CAS No. | 127785-64-2 |
|---|---|
| Summenformel | C60H92N8O11 |
| Durchschnittliche Molmasse | 1.101,4 g/mol |
| Monoisotopische Masse | 1.100,68855578 g/mol |
| SMILES | CC[C@@H](C)[C@@H]1OC(=O)[C@H](C(C)(C)O)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O |
| InChIKey | RLMLFADXHJLPSQ-NPPFTVEMSA-N |
| PubChem CID | 72050 |
Chemische & physikalische Eigenschaften
| XLogP | 8,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 235 |
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 11 |
| Frei drehbare Bindungen | 13 |
| Schwere Atome | 79 |
| Formalladung | 0 |
| Komplexität | 2.110 |
| Siedepunkt | 1229.1±65.0 °C(Predicted) |
| Dichte | 1.19±0.1 g/cm3(Predicted) |
| Lagerbedingungen | Store at -20°C, protect from light |
| Löslichkeit | DMSO : 100 mg/mL (90.79 mMNeed ultrasonic) |
| pKa (Säurekonstante) | 13.35±0.70(Predicted) |
| Aggregatzustand | Solid |
| Farbe | White to off-white |
| InChIKey | RLMLFADXHJLPSQ-UBDQFPLBNA-N |
Anwendungen & Verwendung
Verwenden
Basifungin, also known as aureuobacidin A, is an orally available cyclic depsipeptide antibiotic produced by Aureobasidium pullulans that is a fungicide at low concentrations. Aureobasidin A inhibits inositol phosphorylceramide synthase, an enzyme that catalyzes a key step in fungal sphingolipid biosynthesis. This may inhibit fungal cell growth.