Ubenimex

HCID 72172CAS 58970-76-6

Grundinformationen

Standard-SMILES
CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O
InChIKey
VGGGPCQERPFHOB-RDBSUJKOSA-N
Summenformel
C16H24N2O4
Durchschnittliche Molmasse
308,37 g/mol
Monoisotopische Masse
308,17360725

Namen und Bezeichner

Bevorzugter Name
Ubenimex
IUPAC
(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
Englischer Name
Bestatin hydrochloride
Summenformel
C16H25ClN2O4
Molmasse
344.83

Namen und Synonyme

BestatinUbenimex58970-76-6NK-421UbenimexumNK 421I0J33N5627NSC-265489((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine(3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine(S-(R*,S*))-N-(3-Amino-2-hydroxy-4-phenylbutyroyl)-L-leucineL-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, (S-(R*,S*))-
Weitere Namen anzeigen
Bestatin.HCIBESTATIN HCLUbenimex HClUbenimex-d7 HClUbenimex hydrochlorideHYDROCHLORIDE,UbenimexBestatin HCl - Bio-X ?Wufenmei HydrochlorideBestatin hydrochlorideBestatin research grade
(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acidNSC265489DTXSID4048430(2S)-2-(((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)amino)-4-methylpentanoic acidRefChem:9009613-amino-2-hydroxy-4-phenylbutyryl-L-leucine2-((3-amino-2-hydroxy-4-phenylbutanoyl)amino)-4-methylpentanoic acidDTXCID0028404

Datenbank-Bezeichner

CAS
58970-76-6、65391-42-6
PubChem CID
72172
DTXSID
DTXSID301369975
ChEMBL
CHEMBL29292
UNII
I0J33N5627
EC Number
261-529-2
Nikkaji
J12.831G

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-1
Polarare Oberfläche (TPSA)
113 Ų
H-Brücken-Donoren
4
H-Brücken-Akzeptoren
5
Frei drehbare Bindungen
8
Schwere Atome
22

Physikochemische Eigenschaften

Schmelzpunkt
216 · 216-218 °C
storage temp.
2 · 2-8°C
Löslichkeit
2 O: · H2O: 25 mg/mL, clear, colorless
Aggregatzustand
White to off-white powder.
Farbe
White
Biologische Quelle
synthetic (organic)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Hazard Classes and CategoriesSkin Irrit. 2 (100%);Eye Irrit. 2 (100%);STOT SE 3 (100%)

Sicherheitsdaten

F
3-10
wgk
3
hs_code
29242995
risk_code
20/21/22-36/37/38
hazard_code
Xn
safety_code
22-24/25-36-26

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 6 Einträge

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.

Biologically active substances whose activities affect or play a role in the functioning of the immune system.

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.

Substances that inhibit the growth or reproduction of BACTERIA.

Anwendungen

Verwendencompetitive aminopeptidase B inhibitor

Anbieter50 Anbieter

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
陕西缔都新材料有限公司81124267 17392282731 · [email protected]

Zugehörige Reaktionen

3

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