HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Toluidin (o)
2-METHYLANILINE · ORTHO-TOLUIDINE · o-Toluidin · 2-Toluidine · 2-AMINOTOLUENE · 2-AMINO-1-METHYLBENZENE · toluidines · 0-Toluidine
Identifikatoren & physikalische Daten
| CAS No. | 95-53-4 |
|---|---|
| Summenformel | C7H9N |
| Durchschnittliche Molmasse | 107,15 g/mol |
| Monoisotopische Masse | 107,07349929 g/mol |
| SMILES | Cc1ccccc1N |
| InChIKey | RNVCVTLRINQCPJ-UHFFFAOYSA-N |
| PubChem CID | 7242 |
| ChEMBL | CHEMBL1381 |
| ChEBI | CHEBI:66892 |
| EC No. | 202-429-0 |
| DTXSID | DTXSID1026164 |
| Lokaler Name | Toluidin (o) |
Chemische & physikalische Eigenschaften
| XLogP | 1,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 26 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 8 |
| Formalladung | 0 |
| Komplexität | 70,8 |
| Stoffklassen | Hazardous Air Pollutants (HAPs)Nitrogen Compounds -> Amines, AromaticCarcinogensDye |
| SpringerMaterials Properties | 13C nuclear magnetic resonance spectrum |
| LogP (Verteilungskoeffizient) | log Kow = 1.321.431.44 |
| Geruch | Aromatic aniline-like odor |
| Dichte | 0.998 at 68 °F (USCG, 1999) - Less dense than waterwill float0.9984 g/cu cm at 20 °CRelative density (water = 1): 1.000.9984 @ 20°C1.011.008 g/mL at 25 °C(lit.) |
| Viscosity | 3.823 mPa-s at 25 °C |
| Color/Form | Light yellow liquid becoming reddish brown on exposure to air and lightColorless to pale-yellow liquid |
| Löslichkeit | 5 to 10 mg/mL at 59 °F (NTP, 1992)Soluble in alcohol and etherMiscible in ethanol, diethyl ether, carbon tetrachlorideSoluble in dilute acidsIn water, 1.66X10+4 mg/L at 25 °C16.6 mg/mL at 25 °C1.5 g/100 mL (25°C)1.5 g/100 mL (25 ºC) |
| Flammpunkt | 185 °F (NTP, 1992)185 °F (85 °C) (Closed cup)85 °C c.c. |
| Siedepunkt | 392 to 396 °F at 760 mmHg (NTP, 1992)200.3 °C200 °C392 °F200.3 °C @760 [mm Hg]199-200 °C(lit.) |
| Decomposition | When heated to decomposition, it emits toxic fumes of hydrochloric acid and nitrogen oxides. |
| Schmelzpunkt | 2.7 °F (NTP, 1992)-14.41 °CMelting point: -23.7 °C (alpha form)-14.7 °C (beta form)-16.3 °C-16 °C (beta-form)-23 °C |
| Dampfdichte | 3.7 (vs air) |
| Dampfdruck | 0.26 mm Hg ( 25 °C) |
| Brechungsindex | n20/D 1.572(lit.) |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | liquid |
| pKa (Säurekonstante) | 4.44(at 25℃) |
| Farbe | light yellow to light amber |
| pH | 7.4 (H2O, 20℃)Aqueous solution |
| Geruch | Aromatic, aniline-like. |
| Explosionsgrenze | 1.5-7.5%(V) |
| Spezifische Wärmekapazität | Cp(gas): 1.22 J/(g·K), at 25℃ |
| Merck | 14,9536 |
| BRN | 741981 |
| Henry-Konstante | 1.98 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999) |
| Dielektrizitätskonstante | 6.3399999999999999 |
| Hauptanwendungen | cleaning productscosmeticsenvironmentalfood and beveragespersonal care |
| InChI | 1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3 |
| InChIKey | RNVCVTLRINQCPJ-UHFFFAOYSA-N |
| SMILES | Cc1ccccc1N |
| LogP (Verteilungskoeffizient) | 1.4 at 24.5℃ |
| CAS Datenbank | 95-53-4(CAS DataBase Reference) |
| NIST chemische Informationen | Benzenamine, 2-methyl-(95-53-4) |
| EPA chemische Informationen | o-Toluidine (95-53-4) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P304+P340, P305+P351+P338, P316, P318, P321, P330, P337+P317, P391, P403+P233, P405, and P501 (click each P-code to see the statement)H301+H331 (32.9%): Toxic if swallowed or if inhaled [Danger Acute toxicity, oralacute toxicity, inhalation]P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P317, P318, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) |
|---|---|
| Regulatorische Informationen | Chemical: Benzenamine, 2-methyl-Benzenamine, 2-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzenamine, 2-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 15-12-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/14441Substance: o-toluidine2-Toluidine: HSNO Approval: HSR003090 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| Weitere Sicherheitsinformationen | IMAP assessments - Benzenamine, 2-methyl-: Environment tier I assessment |
| DOT-Kennzeichnung | Poison |
| Brandgefahren | Special Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire. (USCG, 1999)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 85 °C explosive vapour/air mixtures may be formed. |
| Brandpotenzial | Flammable when exposed to heat or flame. |
| Gesundheitsgefahren | Absorption of toxic quantities by any route causes cyanosis (blue discoloration of lips, nails, skin)nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation. (USCG, 1999) |
| Gefahrenübersicht | o-Toluidine is primarily used in the manufacture of dyes. o-Toluidine is highly toxic to humans when absorbed through the skin, inhaled as vapor, or swallowed. Acute (short-term) exposure of humans to o- toluidine affects the blood (i.e., methemoglobinemia), with clinical signs of central nervous system depression. The chronic (long-term) effects in workers exposed to o-toluidine include anemia, anorexia, weight loss, skin lesions, central nervous system depression, cyanosis, and methemoglobinemia. Animal studies indicate that chronic exposure too-toluidine causes effects on the spleen, liver, urinary bladder, and blood. Occupational exposure to dyestuffs (including o-toluidine) is associated with an increased risk of bladder cancer. 2-Methylaniline hydrochloride (the hydrochloride salt of o-toluidine) was carcinogenic in rats and mice. o-Toluidine has been classified by EPA as a Group B2, probable human carcinogen.Methemoglobinemia, bladder irritation, and hematuria have been reported in exposed workers. Listed in the table Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity[ACGIH] May cause methemoglobinemia and kidney injury[ICSC] |
| DOT-Nummer und Handbuch | 1708 153 |
| Reaktive Gruppe | Amines, Aromatic |
| EG-Einstufung | Symbol: T, NR: 45-23/25-36-50S: 53-45-61Note: E |
| UN-Einstufung | UN Hazard Class: 6.1UN Pack Group: II |
| Special Reports | National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. o-Toluidine (95-53-4) and o-Toluidine Hydrochloride are listed as reasonably anticipated to be human carcinogens. /o-Toluidine and o-Toluidine Hydrochloride/[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s178otol.pdf]IARC. Ortho-Toluidine in Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer vol 77, Some Industrial Chemicals, p.267-322 (2000).[Available from, as of June 17, 2010: http://monographs.iarc.fr/index.php]Organization for Economic Cooperation and DevelopmentScreening Information Data Set for o-Toluidine (95-53-4) (October, 2004). This OECD Initial Assessment of HPV Chemicals is part of a series of OECD SIDS documents published by UNEP Chemicals to facilitate the access to information needed for health and environmental risk assessments of chemicals.[Available from, as of April 28, 2010: http://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html]European Commission, ESISIUCLID Dataset, o-Toluidine (95-53-4) (2000 CD-ROM edition) contains information on use, toxicology, and environmental effects of this chemical as supplied to the European Union by industry..[Available from, as of May 18, 2010: http://esis.jrc.ec.europa.eu/] |
| Brandbekämpfung | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.Rinse mouth. Refer immediately for medical attention. |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.(General first aid procedures) |
| Sichere Lagerung | Provision to contain effluent from fire extinguishing. Separated from strong oxidants, strong acids and food and feedstuffs. Well closed. Ventilation along the floor. Keep in the dark. Store in an area without drain or sewer access. |
| Expositionsschutz und Persönliche Schutzausrüstung | Biological Exposure Indices (BEI) [ACGIH] - Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
| Brandbekämpfungsverfahren | Use dry chemical, carbon dioxide, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full facepieces and are operated in a pressure-demand or other positive-pressure mode.Use water spray, dry chemical, foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool.Water may be ineffective on fire. Cool exposed containers with water.If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical or carbon dioxide. |
| Lagerbedingungen | Before entering confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. o-Toluidine must be stored to avoid contact with strong oxidizers (such as chlorine, bromine, and fluorine) because violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat. Sources of ignition, such as smoking and open flames, are prohibited where o-toluidine is used, handled, or stored in a manner that could creats a potential fire or explosion hazard. A regulated, marked area should be established where this chemical is handled, used, or stored ...Separate from oxidizing materials. Store in cool, dry, well-ventilated location. Store away from heat and sunlight.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ |
| Reinigungsverfahren | PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/Spill handling: evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations.Approach release from upwind. Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors and protect personnel. Absorb in noncombustible material for proper disposal. Control runoff and isolate discharged material for proper disposal.Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. |
| Freisetung ohne Brand | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: |
| Entsorgungsverfahren | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U328, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.Toluidine is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices). /Toluidine/Controlled incineration (oxides or nitrogen are removed from the effluent gas by scrubbers and/or thermal devices).PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/For more Disposal Methods (Complete) data for 2-Aminotoluene (9 total), please visit the HSDB record page. |
| Verschüttetes entsorgen | Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
| Preventive Measures | MOST EFFECTIVE MEASURE FOR PREVENTION OF URINARY BLADDER TUMORS RESULTING FROM MFR OF TOLUIDINES IS USE OF CATALYTIC METHOD. MAX PERMISSIBLE CONCN SHOULD BE REVISED, TAKING INTO ACCOUNT 2-AMINOTOLUENE CARCINOGENIC ACTIVITY.If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors.Personnel protection: Avoid breathing vapors. Keep upwind ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.For more Preventive Measures (Complete) data for 2-Aminotoluene (18 total), please visit the HSDB record page. |
| Körperbelastung | 2-Aminotoluene has been found in humans as a metabolite of aptocaine, a local anesthetic(1). |
| Cancer Sites | [bladder cancer] |
| Wechselwirkungen | SC ADMIN OF BENZIDINE & O-TOLUIDINE SIMULTANEOUSLY TO 116 RATS RESULTED IN EARLIER APPEARANCE OF TUMORS. LATENT PERIOD FOR BENZIDINE WAS TWICE AS LONG AS WITH COMBINED USE (548.6 DAYS & 264.1 DAYS). |
| Zielorgane | Eyes, skin, blood, kidneys, liver, cardiovascular system |
| Ökotoxizitätswerte | LC50Species: Carassius auratus (goldfish)Conditions: staticConcentration: 124 mg/L for 48 hrSpecies: Cyprinus carpio (common carp)Concentration: 78.5 mg/L for 48 hrSpecies: Leuciscus idus melanotus (Golden ide)Concentration: 117 mg/L for 48 hrSpecies: Leuciscus idus (ide)For more Ecotoxicity Values (Complete) data for 2-Aminotoluene (56 total), please visit the HSDB record page. |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), measured Koc values ranging from 40 to 250(2), indicate that 2-aminotoluene is expected to have very high to moderate mobility in soil(SRC). The pKa of 2-aminotoluene is 4.44(3), indicating that this compound will partially exist in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of 2-aminotoluene from moist soil surfaces is expected to be an important fate process for the neutral species(SRC) given a Henry's Law constant of 1.98X10-6 atm-cu m/mole(5). 2-Aminotoluene is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.26 mm Hg at 25 °C(6). 2-Aminotoluene reached 65% of its theoretical BOD in activated sludge in 4 weeks(7) and in another experiment 500 ppm of 2-aminotoluene completely degraded in 3 days in a Chernozem soil(8). These results suggest that 2-aminotoluene will be readily biodegradable in the terrestrial environment. Additionally, aromatic amines undergo soil- and clay-catalyzed free radical oxidations, reactions that are facilitated by electron-donating groups such as the methyl group on 2-aminotoluene(9,10). They are also readily oxidized by metal ions that may occur in soil(11).AQUATIC FATE: Based on a classification scheme(1), measured partition coefficients for 2-aminotoluene between sediment and water ranging from 40 to 250(2), indicate that 2-aminotoluene is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.98X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 19 and 140 days, respectively(SRC). Studies of a model aquatic ecosystem show that 2-aminotoluene should mainly partition into the water phase (83.3%), although the chemical also partitioned into the air (14.5%) and sediment (1.9%) phases(5). According to a classification scheme(6), an estimated BCF of 3.5(SRC), from a log Kow of 1.32(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 2-Aminotoluene reached 65% of its theoretcal BOD in activated sludge in 4 weeks(9) and in another experiment >90% of 2-aminotoluene was degraded after 7 days in two screening tests designed to simulate surface waters and polluted river water(10). These data suggest that 2-aminotoluene will be readily biodegradable in the aquatic environment. Additionally, aromatic amines are readily oxidized by metal ions that may occur in natural waters(11).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-aminotoluene, which has a vapor pressure of 0.26 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-aminotoluene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 2.9 hours(SRC), calculated from its rate constant of 1.32X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 2-Aminotoluene has UV absorption which extends beyond 290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). |
| Lebensmitteluntersuchungswerte | In a German survey of primary and secondary amines in the human environment, < 0.1 ppm of 2-aminotoluene was detected in a sample of broken beans(1). It was not found, however, in 9 other samples of preserved vegetables, or samples of maize, salad, rhubarb, and apples, pickles, fish, cheese, bread, coffee, tea, cocoa, wine, malt, hops, barley, or animal feed(1). Aminotoluene, isomer unspecified, was found in shelled peas and red cabbage at a concentration of 0.4 and 0.2 ppm, respectively and in kale, carrots and celery at 1.1, 7.2, and 1.1 ppm, respectively(1). 2-Aminotoluene has been identified as a volatile in black tea(2,3). |
| Unerwünschte Wirkungen | Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting. |
| Expositionspfade | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| Milk Concentrations | In human milk from 7 smokers and 24 non-smokers, there were < 0.01 to 0.26 ppb (ng/g) o-toluidine, with an average of 0.04 ppb (for comparison, the level of aniline was 0.36 ppb and of N-methylaniline 0.55 ppb). No significant differences between the two groups were observed. None of the women reported occupational exposure to aromatic amines. The authors explain their observation with the occurrence of aromatic amines in tobacco smoke, fresh vegetables and the aroma of black tea. |
| Toxizitätsübersicht | IDENTIFICATION: ortho-Toluidine is a synthetic chemical that is a light yellow liquid at ambient temperature. It is used primarily in the manufacture of dyestuffs, although it is also used in the production of rubber, chemicals and pesticides and as a curing agent for epoxy resin systems. HUMAN EXPOSURE: In the occupational environment, there is the potential for significant carcinogenic and genotoxic effects. ANIMAL STUDIES: o-Toluidine is of moderate to low acute toxicity and has the potential to produce minimal skin irritation and mild irritation. Information was not available on the skin or respiratory sensitization potential of o-toluidine. The principal signs of toxicity following acute short term exposure to this chemical are methemaglobinemia and related effects on the spleen. These effects have been observed in rats administered o-toluidine at 225 mg/kg bw/day for 5 days. A no observed adverse effect level (NOEL) has not been identified. In several carcinogenicity studies in which o-toluidine wasadministered orally to rats and mice, there was a significant increase in the incidence of benign and malignant tumors in various tissues. o-Toluidine is generally non-mutagenic in standard bacterial mutagenicity tests, but is clastogenic in mammalian cells in vitro. There is uncertainty concerning the genotoxicity of o-toluidine in vivohowever, some positive results have been reported. Based on the wide distribution of tumors in o-toluidine exposed animals, as well as the clastogenic activity observed in mammalian in vitro assays, o-toluidine may be acting as a genotoxic carcinogen. Information relevant to assessing the risks of reproductive or developmental effects of o-toluidine was not identified. |
| Signs and Symptoms | Blue lips, fingernails and skin. Confusion. Dizziness. Headache. Shortness of breath. Weakness. Convulsions. Nausea. Unconsciousness.MAY BE ABSORBED! Redness. Blue lips, fingernails and skin. Further see Inhalation.Redness. Pain.Blue lips, fingernails and skin. Dizziness. Headache. Laboured breathing. Further see Inhalation.irritation eyesanoxia, headache, cyanosislassitude (weakness, exhaustion), dizziness, drowsinessmicro hematuria (blood in the urine)eye burnsdermatitis[potential occupational carcinogen] |
| RCRA-Anforderungen | U328As stipulated in 40 CFR 261.33, when o-toluidine, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5). |
| TSCA-Anforderungen | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Benzenamine, 2-methyl- is included on this list. Effective date 3/7/86Sunset date: 12/19/95. |
| Luftstandards | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Toluidines are produced, as an intermediate or a final product, by process units covered under this subpart. /Toluidines/Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. 2-Aminotoluene is included on this list. |
| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| Landesrichtlinien für Trinkwasser | (FL) FLORIDA 50 ug/L |
| F | 8-10-23 |
| Wassergefährdungsklasse (WGK) | 3 |
| Sofort lebensgefährliche Konzentration | 50 ppm |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 2920 8/PG 1 |
| Zollcode | 29214300 |
| RTECS-Nr. | XU2975000 |
| R-Sätze (R) | 45-23/25-36-50-35-20/22-10-39/23/24/25-23/24/25-11 |
| Toxizität | LD50 orally in rats: 0.94 g/kg (Smyth) |
| Gefahrensymbole | T,N,F |
| Sicherheitshinweise (S) | 53-45-61-36/37/39-26-36/37-16-7 |
| Gefahrenklasse | 6.1Acute Tox. 3 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 2Carc. 1BEye Irrit. 2 |
| Verpackungsgruppe | II |
| Lagerklasse | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| Gefahrstoffdaten | 95-53-4(Hazardous Substances Data) |
| Selbstentzündungstemperatur | 899 °F |
Anwendungen & Verwendung
Occurrence
O-Toluidine has been reported to be a component of tar produced by low-temperature carbonization of coal and has been detected in gasoline fractions from arlan petroleum, tobacco leaf extracts, and in the aroma components of black tea (Anon. 1972). Patrianakos and Hoffmann (1979) detected it in tobacco smoke. It is a metabolite of prilocaine anesthetic in rats (Akerman et al 1966) and humans (Hjelm et al 1972; Struck et al 1969). It is a possible contaminant of bootleg methaqualone (Goldfarb and Finelli 1974) but is not a methaqualone metabolite (Nowak et al 1966). It is also a metabolite of the dye Poncean 3R (Lindstrom et al 1969).O-Toluidine has been detected as a contaminant in injectables stored in polystyrene (Ahmad, 1982).
Verwenden
A carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. o-Toluidine, is a methemoglobin-inducing chemical and a human carcinogen. Commercial production of o-toluidine was first reported in the United States in 1922. o-Toluidine and its hydrochloride salt are used primarily as intermediates in the manufacture of dyes and pigments for printing textiles, in color photography, and as biologic stains. In addition, o-toluidine is used as an intermediate for rubber vulcanizing chemicals, pharmaceuticals, and pesticides. Other minor uses include intermediate for organic synthesis and clinical laboratory reagent for glucose analysis (IARC, 2000, 2010; Woo and Lai, 2012).