2-Amino-p-kresol

2-Amino-4-methylphenol

HCID 7264CAS 95-84-1

Grundinformationen

Standard-SMILES
Cc1ccc(O)c(N)c1
InChIKey
ZMXYNJXDULEQCK-UHFFFAOYSA-N
Summenformel
C7H9NO
Durchschnittliche Molmasse
123,15 g/mol
Monoisotopische Masse
123,06841391

Überblick

2-amino-4-methylphenol is a brown powder. (NTP, 1992)

Namen und Bezeichner

Bevorzugter Name
2-Amino-4-methylphenol
IUPAC
2-amino-4-methylphenol
Lokaler Name
2-Amino-p-kresol
Englischer Name
2-Amino-p-cresol
Summenformel
C7H9NO
Molmasse
123.15

Namen und Synonyme

2-Amino-4-methylphenol95-84-12-Amino-p-cresol2-Hydroxy-5-methylaniline3-Amino-4-hydroxytoluene6-Hydroxy-m-toluidine4-Methyl-2-aminophenolPhenol, 2-amino-4-methyl-5-Methyl-2-hydroxyanilinep-Cresol, 2-amino-DTXSID40244881-amino-2-hydroxy-5-methylbenzene
Weitere Namen anzeigen
O-AMINO-P-METHYLPHENOL2-AMINO-PARA-CRESOL, 97%CRESAMINEO-AMINO-P-CRESOL2-Amino-p-kresol
9ZV2574SER1-HYDROXY-2-AMINO-4-METHYLBENZENENSC-7630NSC-60737DTXCID804488RefChem:85218202-457-32-Amino-4-cresol

Datenbank-Bezeichner

CAS
95-84-1
PubChem CID
7264
DTXSID
DTXSID4024488
ChEMBL
CHEMBL224282
ChEBI
CHEBI:39713
UNII
9ZV2574SER
EC Number
202-457-3
Nikkaji
J95.381D

Eigenschaften

Berechnete Struktureigenschaften

XLogP
1,2
Polarare Oberfläche (TPSA)
46,3 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
0
Schwere Atome
9

Experimentelle und physikochemische Eigenschaften

Chemical ClassesNitrogen Compounds -> Amino Phenols
DrugsPharmaceuticals -> Listed in ZINC15
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Boiling PointSublimes (NTP, 1992)
Melting Point279 °F (NTP, 1992)
Vapor Pressure0.00308 [mmHg]

Physikochemische Eigenschaften

Schmelzpunkt
133 · 133-136 °C(lit.)
Siedepunkt
229.26 °C · 229.26°C (rough estimate)
Dichte
1.0877 · 1.0877 (rough estimate)
Brechungsindex
1.5706 · 1.5706 (estimate)
storage temp.
Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit
slightly soluble

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 1.5% (1 of 65) of reports.

Warning

H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 65 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Status: Active Update: 20-02-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/20332

Phenol, 2-amino-4-methyl-: Does not have an individual approval but may be used under an appropriate group standard

DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available, however it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes and mucous membranes.
Hazards SummaryA skin, eye, and mucous membrane irritant; [NTP] A skin and strong eye irritant; [Sigma-Aldrich MSDS]
Reactive GroupPhenols and Cresols

Sicherheit und Schutzausrüstung

Fire FightingFires involving this compound can be extinguished using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 Eintrag

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 Eintrag

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:
Personal Protective Equipment (PPE) · 1 Eintrag

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Sicherheitsdaten

wgk
2
tsca
TSCA listed
hs_code
29222900
RTECS-Nr.
SJ6078000
risk_code
36/37/38
hazard_code
Xi

Chemie und Industrie

Verwendung und Herstellung

UsesUsed as an intermediate for organic chemicals and dyes; [NTP]
General Manufacturing InformationPhenol, 2-amino-4-methyl-: ACTIVE

Anwendungen

BeschreibungDas 2-Amino-4-methylphenol bildet gelbbraune, wasserunlösliche Kristalle. Die Verbindung wurde zur Herstellung von Azofarbstoffen verwendet, ist heute aber ohne technische Bedeutung.

Verwenden2-Amino-4-methylphenol was used in the synthesis of novel functionalized spiropyran derivatives of 2H-1,3-benzoxazinone series.

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