Ganoderenic acid A
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Grundinformationen
- CAS
100665-40-5- Standard-SMILES
CC(=CC(=O)CC(C)C(=O)O)C1CC(O)C2(C)C3=C(C(=O)CC12C)C1(C)CCC(=O)C(C)(C)C1CC3O- InChIKey
OVUOUFPIPZJGME-UHFFFAOYSA-N- Summenformel
- C30H42O7
- Durchschnittliche Molmasse
- 514,659 g/mol
- Monoisotopische Masse
- 514,29305368
Namen und Bezeichner
- Bevorzugter Name
- Ganoderenic acid A
- IUPAC
- 7,15-Dihydroxy-3,11,23-trioxolanosta-8,20(22)-dien-26-oic acid
- Englischer Name
- ganoderenic acid A
- Summenformel
- C30H42O7
- Molmasse
- 514.66
Namen und Synonyme
ganoderenic acid AGanoderenic acid A, 10 mM in DMSO5R)-2-Isopropyl-5-Methylcyclohexanol(20E)-7β,15α-Dihydroxy-3,11,23-trioxolanosta-8,20(22)-diene-26-oic acid(20E)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanosta-8,20(22)-dien-26-oic acidLanosta-8,20(22)-dien-26-oicacid, 7,15-dihydroxy-3,11,23-trioxo-, (7b,15a,20E)-Lanosta-8,20(22)-dien-26-oic acid, 7,15-dihydroxy-3,11,23-trioxo-, (7β,15α,20E)-(E)-6-((5R,7S,10S,13R,14R,15S,17R)-7,15-Dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
Datenbank-Bezeichner
- CAS
100665-40-5- PubChem CID
- 72728371
- DTXSID
DTXSID301316083
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 700.3 · 700.3±60.0 °C(Predicted)
- Dichte
- 1.24 · 1.24±0.1 g/cm3(Predicted)
- Löslichkeit
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- Aggregatzustand
- Powder
- pka
- 4.65 · 4.65±0.23(Predicted)
- Farbe
- White to off-white
- InChIKey
- OVUOUFPIPZJGME-UHFFFAOYSA-N
- SMILES
- CC12C(CC(C(C)=CC(=O)CC(C)C(=O)O)C1(CC(=O)C1C3(CCC(=O)C(C)(C)C3CC(O)C2=1)C)C)O
Chemie und Industrie
Anwendungen
BeschreibungGanoderenic acid A is a triterpenoid originally isolated from G. lucidum that has enzyme inhibitory activities. It is an inhibitor of β-glucuronidase (IC50 = 0.12 mg/ml in rat liver microsomes). Ganoderenic acid A (100 mg/kg) reduces increases in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in a rat model of liver injury induced by carbon tetrachloride (CCl4). It also inhibits aldose reductase by 54.2% when used at a concentration of 100 μg/ml.
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