1,3-Dichloro-2-propanol

1.3506 at 63 °F (NTP, 1992) - Denser than water; will sink

1.3506 @ 17 °C/4 °C

Relative density (water = 1): 1.35

1.367 @ 20°C

greater than or equal to 100 mg/mL at 73 °F (NTP, 1992)

MISCIBLE WITH ALC, ETHER

SOL ETHANOL, ETHER, ACETONE

MISCIBLE WITH MOST ORGANIC SOLVENTS, VEGETABLE OILS

In water, 9.9X10+4 mg/l at 25 °C.

Solubility in water, g/100ml at 20 °C: 11

165 °F (NTP, 1992)

74 °C

165 °F (74 °C) (OPEN CUP)

74 °C o.c.

345 °F at 760 mmHg (NTP, 1992)

174.3 °C @ 760 MM HG

174.3 °C

174 °C @760 [mm Hg]

25 °F (NTP, 1992)

-4 °C

-4 °C

4.45 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

4.4 (AIR= 1)

Relative vapor density (air = 1): 4.4

Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]

P203, P264, P270, P280, P301+P316, P302+P352, P317, P318, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)

Danger

H301+H311 (75.6%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]

P203, P260, P261, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P320, P321, P330, P361+P364, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Chemical: 2-Propanol, 1,3-dichloro-

Hazard Traits - Carcinogenicity

2-Propanol, 1,3-dichloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propanol, 1,3-dichloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 10-03-2014 https://echa.europa.eu/registration-dossier/-/registered-dossier/12450

1,3-Dichloro-2-propanol: Does not have an individual approval but may be used under an appropriate group standard

Poison

Poison

This chemical is combustible. (NTP, 1992)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

· Combustible material: may burn but does not ignite readily.

Combustible.

SYMPTOMS: Symptoms of exposure to this compound include hemorrhagic gastritis and pharyngitis. Other symptoms include headache, vertigo, nausea, vomiting, pulmonary edema and liver damage.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

· TOXIC and/or CORROSIVE; inhalation, ingestion or skin contact with material may cause severe injury or death.

A skin, eye, mucous membrane, and respiratory tract irritant; Toxic by inhalation and ingestion; Harmful by skin absorption; May cause liver injury; [CAMEO] An irritant; May be absorbed through skin; Effects in high-dose animal studies include toxic hepatitis; [MSDSonline] Danger of cutaneous absorption; Carcinogenic for man (Group 2); [MAK]

Alcohols and Polyols

Alcohols and Polyols

Sensitive to heat. Incompatible with oxidizers. Also incompatible with strong acids, strong reducing agents, acid chlorides and acid anhydrides. (NTP, 1992)

A halogenated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Use fine water spray, alcohol-resistant foam, dry powder, carbon dioxide.

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

General First Aid:

"ALCOHOL" FOAM.

To fight fire, use alcohol foam, dry chemical, fog, mist, or spray.

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Immediate precautionary measure

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4(SRC), determined from a structure estimation method(2), indicates that 1,3-dichloro-2-propanol is expected to have very high mobility in soil(SRC). Volatilization of 1,3-dichloro-2-propanol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6X10-7 atm-cu m/mole(SRC), obtained using a fragment constant estimation method(3). 1,3-Dichloro-2-propanol is not expected to volatilize from dry soil surfaces(SRC) based upon an experimental vapor pressure of 0.75 mm Hg(4). Based upon conflicting results with aerobic aqueous screening biodegradation tests(5), the importance of biodegradation in soil is unknown.

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4(SRC), determined from a structure estimation method(2), indicates that 1,3-dichloro-2-propanol is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 6X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(3,SRC), from an estimated log Kow of 0.78(6,SRC), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A neutral first-order and base-catalyzed second-order hydrolysis rate constant for 1,3-Dichloro-2-propanol of 3.1X10-3 1/hr and 850 L/mole-hour(2) correspond to half-lives of 1.4 years and 34 days at pH values of 7 and 8, respectively(7,SRC). Based upon conflicting results with aerobic aqueous screening biodegradation tests(8), the importance of biodegradation in water is unknown.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,3-dichloro-2-propanol, which has a vapor pressure of 0.75 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,3-dichloro-2-propanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 8 days(SRC) from its estimated rate constant of 1.8X10-12 atm cu m/mol(3).

Cough. Sore throat.

MAY BE ABSORBED! Redness.

Redness. Pain.

See Inhalation.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 1,3-dichloro-2-propanol can be estimated to be about 4(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1,3-dichloro-2-propanol is expected to have very high mobility in soil.

Toxicity of 1,3-dichloro-2-propanol (DCP) with respect to testicular changes was evaluated in male albino Wistar rats (10/treated group, 20 in water vehicle control group) exposed orally to TCP by gavage at dosage levels of 0, 15 or 60 mg/kg/day for 14 days. On day 15, the animals were sent for pathological examination. Significant differences between treated and control animals were observed only in the appearance of small spermatocoele or sperm granuloma formation in the ductili efferentes and/or epididymides. No significant differences between treated and control animals were observed in the following: body weights, testes weights, morphology, or detailed macroscopic and microscopic examination of the kidneys, testes, and vasa deferentes.

MODERATELY TOXIC BY INHALATION AND INGESTION.

Two middle aged men developed severe hepatic injury just after cleaning a dichloropropanol tank at a plant producing dichloropropanol. They died from hepatic failure 4 and 11 days respectively, after carrying out the work. Liver specimens taken at autopsy from one of the cases showed submassive hepatic necrosis. /Dichloropropanol/

Poison by ingestion and inhalation. Moderately toxic by skin contact. Action may be similar to that of carbon tetrachloride, but more irritating to mucous membranes.

When incubated with a filtered effluent from a sanitary waste treatment plant, 1,3-dichloro-2-propanol displayed a theoretical 5 day BOD of 1%(1). 1,3-Dichloro-2-propanol reached 0%, 84%, and 86% of its theoretical BOD over 4 weeks using activated sludge inoculum(2). Pure cultures of Psuedomonas sp. degraded 1,3-dichloro-2-propanol to epichlorohydrin, 1-chloro-2,3-propylene diol, glycidol, and ultimately glycerin(3).

1,3-Dichloro-2-propanol

Group 2B: Possibly carcinogenic to humans

Volume 101: (2012) Some Chemicals Present in Industrial and Consumer Products, Food and Drinking-water

2013

2011

An estimated BCF of 3 was calculated for 1,3-dichloro-2-propanol(SRC), using an estimated log Kow of 0.78(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

METAB OF 1,3-DICHLOROPROPAN-2-OL BY RATS RESULTED IN 2 MERCAPTURIC ACID METABOLITES IN URINE, N,N'-BIS(ACETYL)-S,S'-[1,3-BIS(CYSTEINYL)] PROPAN-2-OL & N-ACETYL-S-(2,3-DIHYDROXYPROPYL)CYSTEINE. ALSO PRODUCED BETA-CHLOROLACTATE AS OXIDATIVE METABOLITE.

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.

Used as a solvent (hard resins and nitrocellulose), cement for celluloid, binder for watercolors, and intermediate to make photographic and zapon lacquers; [HSDB]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

SOLVENT FOR HARD RESINS AND NITROCELLULOSE; MFR PHOTOGRAPHIC AND ZAPON LACQUER; CEMENT FOR CELLULOID; BINDER FOR WATERCOLORS.

INT IN ORGANIC SYNTHESIS

All Other Basic Organic Chemical Manufacturing

2-Propanol, 1,3-dichloro-: ACTIVE

Propanol, dichloro-: ACTIVE