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Butanonoxim
MEKO · METHYL ETHYL KETOXIME · BUTANONE OXIME · Ethyl methyl ketone oxime · METHYL ETHYL KETONE OXIME · Exkin 2 · Methylethylketoxim · ETHYL METHYL KETOXIME
Identifikatoren & physikalische Daten
| CAS No. | 96-29-7 |
|---|---|
| Summenformel | C4H9NO |
| Durchschnittliche Molmasse | 87,12 g/mol |
| Monoisotopische Masse | 87,06841391 g/mol |
| SMILES | CCC(C)=NO |
| InChIKey | WHIVNJATOVLWBW-UHFFFAOYSA-N |
| PubChem CID | 7292 |
| ChEMBL | CHEMBL3181847 |
| EC No. | 202-496-6 |
| DTXSID | DTXSID1021821 |
| Lokaler Name | Butanonoxim |
Chemische & physikalische Eigenschaften
| XLogP | 0,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 32,6 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 6 |
| Formalladung | 0 |
| Komplexität | 58,6 |
| Stoffklassen | Nitrogen Compounds -> Oximes |
| LogP (Verteilungskoeffizient) | log Kow = 0.63 |
| Dichte | 0.9232 at 68 °F (NTP, 1992) - Less dense than waterwill float0.9232 g/cu cm at 20 °C0.923 @ 20°C0.924 g/mL at 25 °C(lit.) |
| Color/Form | LiquidColorless liquid |
| Löslichkeit | greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)In water, 100,000 mg/L at 25 °CSoluble in chloroformmiscible with ethanol and etherwater: soluble100g/L at 25°C114 g/L (20 ºC) |
| Flammpunkt | 138 °F (NTP, 1992)140 °F |
| Siedepunkt | 306 °F at 760 mmHg (NTP, 1992)152.5 °C152 °C @760 [mm Hg]59-60 °C15 mm Hg(lit.) |
| Decomposition | When heated to decomposition it emits toxic fumes of /oxides of nitrogen/. |
| Schmelzpunkt | -21.1 °F (NTP, 1992)-29.5 °C-30 °C |
| Dampfdichte | 3 (NTP, 1992) - Heavier than airwill sink (Relative to Air)3 (vs air) |
| Dampfdruck | 22.6 mmHg at 73 °F50.9 mmHg at 118 °F (NTP, 1992)0.9 [mmHg]VP: 7.6 mm Hg at 50 °C1.06 mm Hg at 20 °C<8 mm Hg ( 20 °C) |
| Brechungsindex | Index of refraction = 1.4410 at 20 °C/Dn20/D 1.442(lit.) |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | pK1:12.45 (25°C) |
| Farbe | Clear colorless to pale yellow |
| Geruch | Musty odor |
| BRN | 1698241 |
| Henry-Konstante | 8.1×100 mol/(m3Pa) at 25℃, HSDB (2015) |
| Dielektrizitätskonstante | 3.4(20℃) |
| Stabilität | Stable. Combustible. Incompatible with strong oxidizing agents. May react with strong acids to form an explosive material. |
| InChIKey | WHIVNJATOVLWBW-SNAWJCMRSA-N |
| LogP (Verteilungskoeffizient) | 0.63 at 25℃ |
| CAS Datenbank | 96-29-7(CAS DataBase Reference) |
| NIST chemische Informationen | 2-Butanone, oxime(96-29-7) |
| EPA chemische Informationen | Methyl ethyl ketoxime (96-29-7) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]P203, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P308+P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (2 of 4723) of reports.H312 (> 99.9%): Harmful in contact with skin [Warning Acute toxicity, dermal] |
|---|---|
| Regulatorische Informationen | Chemical: 2-Butanone, oximeHazard Traits - Carcinogenicity2-Butanone, oxime is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Butanone, oxime are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 23-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/149082-Butanone, oxime: HSNO Approval: HSR001191 Approved with controls |
| Weitere Sicherheitsinformationen | Evaluation - 2-Butanone, oxime (MEKO) |
| DOT-Kennzeichnung | Flammable Liquid |
| Brandgefahren | This chemical is combustible. (NTP, 1992) |
| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this compound may include slight eye and skin irritation. It may interfere with alcohol metabolism resulting in the formation of acetaldehyde, blotchy red marks, red eyes, tiredness and visible veins. |
| Gefahrenübersicht | A skin sensitizer[Quick CPC] Dermal sensitization, hemolytic anemia, and CNS depression reported in animal studiesHemolytic effects were seen in a 4-week inhalation study at 533 ppm, but not at 283 ppmMEKO has been produced since 1958, and no adverse effects in workers have been reportedPainters using alkyd paints containing MEKO were exposed at levels <1-2 ppm[AIHA] 8-hour exposure of 12 rats to saturated atmosphere caused no mortalitiesHematological changes (increased methemoglobin and reticulocytes and decreased hemoglobin) observed in 4-week inhalation study of rats at 400 ppm |
Anwendungen & Verwendung
Verwenden
2-Butanone oxime was employed as reagent and solvent in the syntheses of ketoimine and 2,4-dipyridyl-1,3,5-triazapentadiene palladium(II) complexes. It was also used in the synthesis of novel acetaldiimine cobalt complex, [CoI2{((CH3CH2)(CH3)C=NO)2C(CH3)2}]. Methyl ethyl ketoxime is used primarily as an antiskinning agent in alkyd coating resins
Herstellung & Synthese
synthetische
2-Butanone oxime is obtained by the reaction of butanone and hydroxylamine hydrochloride. It can also be synthesized by the reaction between butanone and hydroxylamine sulfate.