TRIMIDOX
VF 233 · TRIMIDOX · Trimidox Exclusive · MSLJYSGFUMYUDX-UHFFFAOYSA-N · N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE · Benzenecarboximidamide, N,3,4,5-tetrahydroxy- · 4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one
Identifikatoren & physikalische Daten
| CAS No. | 95933-74-7 |
|---|---|
| Summenformel | C7H8N2O4 |
| Durchschnittliche Molmasse | 184,15 g/mol |
| SMILES | NC(=NO)c1cc(O)c(O)c(O)c1 |
| InChIKey | MSLJYSGFUMYUDX-UHFFFAOYSA-N |
| PubChem CID | 73313 |
Chemische & physikalische Eigenschaften
| Lagerbedingungen | Store at -20°C |
|---|---|
| Löslichkeit | ≤20mg/ml in DMSO20mg/ml in dimethyl formamide |
| Aggregatzustand | crystalline solid |
Anwendungen & Verwendung
Beschreibung
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 μM.
Verwenden
Trimidox is a specific ribonucleotide reductase inhibitor.