Cobalamin (1+)
Cobalamin
Grundinformationen
- CAS
13408-78-1- Standard-SMILES
C/C1=C2/[N-][C@H]([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP(=O)([O-])O[C@H]2[C@@H](O)[C@@H](n3cnc4cc(C)c(C)cc43)O[C@@H]2CO)[C@]2(C)N=C(/C(C)=C3N=C(/C=C4N=C1[C@@H](CCC(N)=O)C\4(C)C)[C@@H](CCC(N)=O)[C@]\3(C)CC(N)=O)[C@@H](CCC(N)=O)[C@]2(C)CC(N)=O.[Co+2]- InChIKey
ASARMUCNOOHMLO-WLORSUFZSA-L- Summenformel
- C62H88CoN13O14P
- Durchschnittliche Molmasse
- 1.329,3 g/mol
- Monoisotopische Masse
- 1.328,564325
Überblick
Cobalamin is an essential nutrient and natural water-soluble vitamin of the B-complex family that must combine with an intrinsic factor for absorption by the intestine, Vitamin B12 (cyanocobalamin) is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. B12 improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. B12 metabolism is interconnected with that of folic acid. Vitamin B12 deficiency causes pernicious anemia, megaloblastic anemia, and neurologic lesions.
Namen und Bezeichner
- Bevorzugter Name
- Cobalamin
- IUPAC
- cobalt(2+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2S)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate
- Lokaler Name
- Cobalamin (1+)
- Englischer Name
- VITAMIN B12
- Summenformel
- C62H88CoN13O14P
- Molmasse
- 1329.35
Namen und Synonyme
cobalamin8406EY2OQA13408-78-1Vitamin-B12B12 VitaminCHEBI:28911RefChem:577833VIT B12CHEBI:30411236-500-2cobalt(2+);((2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl) ((2S)-1-(3-((1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl)propanoylamino)propan-2-yl) phosphateCobalamin (1+)
Weitere Namen anzeigen
Vitamin B12METHYLCOBALAMINCyanocobalamin (Vitamin B12)CYTAMENvitamin b12 powderCN-CBLCYTACON
COBALAMIN [VANDF]DB14098Q27269456
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 452 Ų
- H-Brücken-Donoren
- 9
- H-Brücken-Akzeptoren
- 19
- Frei drehbare Bindungen
- 26
- Schwere Atome
- 91
- Formalladung
- 0
- Komplexität
- 3.140
Experimentelle und physikochemische Eigenschaften
Human DrugsBreast Feeding; Lactation; Milk, Human; Vitamin B Complex; Vitamins
Physikochemische Eigenschaften
- storage temp.
- 2 · 2-8°C
- InChIKey
- NSLAUEAQDBERRV-UHFFFAOYSA-L
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Toxikologische Informationen
Adverse Effects
Significant pain is the common adverse effect of intramuscular vitamin B12, especially in thin people. Injectable cobalamin may also cause bleeding if the patient is taking anticoagulants. Although allergic reactions rarely happen, they can cause life-threatening anaphylaxis. Injections are more allergenic than pills, and hydroxocobalamin seems to be more allergenic than cyanocobalamin, although reactions can occur with all cobalamin forms. Management options for allergic reactions include desensitization, antihistamines, and steroids.
Toxicity SummaryUsually, cobalamin toxicity or overdose does not occur, and there is no antidote for cobalamin.
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Sicherheitsdaten
- F
- 3-8-10
- wgk
- 1
- RTECS-Nr.
- GG3750000
- safety_code
- 22-24/25
Chemie und Industrie
Ergänzende Hinweise
DefinitionChEBI: A cobalamin in which the central cobalt atom has an oxidation state of +3.
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