HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-Lauroylsarkosin
LAUROYL SARCOSINE · N-DODECANOYL-N-METHYLGLYCINE · Glycine, N-methyl-N-(1-oxododecyl)- · N-LAURYL SARCOSINE · N-LAUROYLSARCOSINATE · Maprosyl L · Sarcosyl L · SARKOSYL L
Identifikatoren & physikalische Daten
| CAS No. | 97-78-9 |
|---|---|
| Summenformel | C15H29NO3 |
| Durchschnittliche Molmasse | 271,4 g/mol |
| Monoisotopische Masse | 271,21474379 g/mol |
| SMILES | CCCCCCCCCCCC(=O)N(C)CC(=O)O |
| InChIKey | BACYUWVYYTXETD-UHFFFAOYSA-N |
| PubChem CID | 7348 |
| ChEMBL | CHEMBL1907464 |
| ChEBI | CHEBI:183705 |
| EC No. | 202-608-3 |
| DTXSID | DTXSID7042011 |
| Lokaler Name | N-Lauroylsarkosin |
Chemische & physikalische Eigenschaften
| XLogP | 4,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 57,6 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 12 |
| Schwere Atome | 19 |
| Formalladung | 0 |
| Komplexität | 254 |
| Stoffklassen | Biological Agents -> Amino Acids and Derivatives |
| Kosmetika | Cosmetic ingredients (Lauroyl Sarcosine) -> CIR (Cosmetic Ingredient Review)CleansingSurfactantAntistaticHair conditioning |
| Surfactants | Surfactant |
| Food Contact Substances | FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR |
| Physical Description | LiquidWhite hygroscopic powder[Sigma-Aldrich MSDS] |
| Collision Cross Section | 170.1 Ų [M-H]- [CCS Type: DTBuffer gas: N2Ionization: ESI-Dataset: TOXCASTSource Identifier: DTXSID7042011] |
| Schmelzpunkt | 45-49 °C |
| Siedepunkt | 413.2±28.0 °C(Predicted) |
| Dichte | 0.97 |
| Dampfdruck | 27.5Pa at 25℃ |
| Lagerbedingungen | Sealed in dry,Room Temperature |
| Löslichkeit | almost transparency in Methanol500mg/L at 25℃ |
| Aggregatzustand | powder to lump to clear liquid |
| pKa (Säurekonstante) | 3.62±0.10(Predicted) |
| Farbe | White or Colorless to Almost white or Almost colorless |
| Geruch | at 100.00%. bland |
| BRN | 1792084 |
| Kosmetik-Inhaltsstoffe Funktionen | ANTISTATICSURFACTANT - CLEANSINGCLEANSINGHAIR CONDITIONING |
| InChI | 1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19) |
| InChIKey | BACYUWVYYTXETD-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCC(=O)N(C)CC(O)=O |
| LogP (Verteilungskoeffizient) | 4.1 |
| CAS Datenbank | 97-78-9(CAS DataBase Reference) |
| EPA chemische Informationen | Glycine, N-methyl-N-(1-oxododecyl)- (97-78-9) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH315 (90.2%): Causes skin irritation [Warning Skin corrosion/irritation]P260, P261, P264, P264+P265, P271, P280, P284, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P320, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 173 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Glycine, N-methyl-N-(1-oxododecyl)-Glycine, N-methyl-N-(1-oxododecyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N-methyl-N-(1-oxododecyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)REACH registered substance: N-lauroylsarcosine (EC: 202-608-3)Glycine, N-methyl-N-(1-oxododecyl)-: Does not have an individual approval but may be used under an appropriate group standard |
| Gefahrenübersicht | A skin and strong eye irritant[Sigma-Aldrich MSDS] See Sarcosine hydrochloride. |
| Hazard Classes and Categories | Skin Irrit. 2 (90.2%) |
| Gesundheitliche Auswirkungen | Acyl sarcosines may cause irritation to the skin and eyes. They may also react to produce N-nitrososarcosine, which is believed to be carcinogenic. (A2881) |
| Expositionspfade | Oral (A2881)inhalation (A2881)dermal (A2881) |
| Toxizitätsübersicht | The CIR Expert Panel concluded that the following ingredients are safe as used in cosmetics when formulated to be non-irritating. The Expert Panel cautions that these ingredients should not be used in cosmetic products in which N-nitroso compounds can be found...Lauroyl Sarcosine...Safe for use in cosmetics, with qualificationsWhile acyl sarcosines themselves are not toxic, they are nitrosating agents. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. The particular nitrosamine produced by acyl sarcosines is N-nitrososarcosine. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1889, L1890, A2878, A2879, A2880, A2881) |
Anwendungen & Verwendung
Verwenden
N-Lauroylsarcosine may be used as a permeation enhancer in the transdermal drug delivery formulations since it increases the fluidity of stratum corneum lipid structure of the skin