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Phenylarsonsure
NSC 15566 · ai3-16050[qr] · Phenylarsonsure · phenylarsenicacid · phenyl-arsonicaci · Phenylarsonic acid · Arsonicacid,phenyl- · BENZENEARSONIC ACID
Identifikatoren & physikalische Daten
| CAS No. | 98-05-5 |
|---|---|
| Summenformel | C6H7AsO3 |
| Durchschnittliche Molmasse | 202,04 g/mol |
| Monoisotopische Masse | 201,96111558 g/mol |
| SMILES | O=[As](O)(O)c1ccccc1 |
| InChIKey | LVKZSFMYNWRPJX-UHFFFAOYSA-N |
| PubChem CID | 7365 |
| ChEMBL | CHEMBL364571 |
| ChEBI | CHEBI:29851 |
| EC No. | 202-631-9 |
| DTXSID | DTXSID6059158 |
| Lokaler Name | Phenylarsonsure |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 57,5 |
|---|---|
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 10 |
| Formalladung | 0 |
| Komplexität | 145 |
| Stoffklassen | Metals -> Arsenic Compounds, Organic |
| LogP (Verteilungskoeffizient) | log Kow= 0.060.03 (calculated) (calculated) |
| Dichte | 1.76 (EPA, 1998) - Denser than waterwill sink1.760 at 25 °CRelative density (water = 1): 1.761.76 @25 °C1,76 g/cm3 |
| Color/Form | Crystal powder |
| Löslichkeit | Sol in 40 parts water, 50 parts alcoholinsol in chloroformSolubility in water: poor3.2% in water and 15.5% in ethanol.31.6g/L(28 ºC) |
| Decomposition | When heated to decomposition it emits toxic fumes of /arsenic/.160 °C |
| Schmelzpunkt | 320 °F decomposes (EPA, 1998)158 °C (with decomp)160 °C |
| Dampfdruck | 0.00000111 [mmHg] |
| Physical Description | Benzenearsonic acid is a colorless solid. Used as an analytical reagent for tin. (EPA, 1998)Colorless solid with various formsPoor solubility in water[ICSC] White powder, soluble in water[MSDSonline]COLOURLESS SOLID IN VARIOUS FORMS. |
| Dissociation Constants | pKa= 8.48 in water at 25 °C |
| Siedepunkt | 66 °C(Press: 1 Torr) |
| pKa (Säurekonstante) | pK2: 8.48(+1) (22°C) |
| Aggregatzustand | Powder |
| Farbe | white |
| Wichte | 1.76 |
| Merck | 14,1067 |
| CAS Datenbank | 98-05-5(CAS DataBase Reference) |
| EPA chemische Informationen | Benzenearsonic acid (98-05-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301 (97.8%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 46 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H301: Toxic if swallowed [Danger Acute toxicity, oral] |
|---|---|
| Regulatorische Informationen | Chemical: Arsonic acid, phenyl-Restricted substance: Phenylarsonic acidPhenylarsonic acid: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| Weitere Sicherheitsinformationen | IMAP assessments - Organoarsenic compounds: Human health tier II assessment |
| DOT-Kennzeichnung | Poison |
| Brandgefahren | Benzenearsonic acid emits poisonous fumes of arsenic when heated to decomposition. (EPA, 1998)Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Gesundheitsgefahren | Benzenearsonic acid is a deadly poison. (Non-Specific -- Arsenic Compounds) Chronic exposure to arsenic compounds can cause dermatitis and digestive disorders. Renal damage may develop. (EPA, 1998) |
| Gefahrenübersicht | Can cause arsenic poisoning[ICSC] Almost nothing is known regarding health effects of organic arsenic compounds in humans. Studies in animals show that some simple organic arsenic compounds are less toxic than inorganic forms. Ingestion of methyl and dimethyl compounds can cause diarrhea and damage to the kidneys. [ATSDR ToxProfiles] Toxic by ingestion[Sax] Oral LDLo (rat) = 50 mg/kg[RTECS] A skin, eye, and mucous membrane irritant[MSDSonline] See Arsanilic acid. |
| Reaktive Gruppe | Acids, Weak |
| EG-Einstufung | Symbol: T, NR: 23/25-50/53S: (1/2)-20/21-28-45-60-61Note: A |
| UN-Einstufung | UN Hazard Class: 6.1UN Pack Group: III |
| FIFRA-Anforderungen | If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/ |
| OSHA Standards | Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/ |
| Reactivity Profile | Benzenearsonic acid emits poisonous fumes of arsenic when heated to decomposition. [EPA, 1998]. |
| Brandbekämpfung | (Non-Specific -- Arsenical Compound, Solid, n.o.s.) Use water in flooding quantities as fog. Avoid breathing dusts and fumeskeep upwindwear self-contained breathing apparatus.In case of fire in the surroundings, use appropriate extinguishing media. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer for medical attention. |
| Erste Hilfe | Warning: Effects usually appear within 30 minutes of exposure but may be delayed for several hours. Caution is advised. |
| Sichere Lagerung | Separated from food and feedstuffs. Dry. |
| Freisetung ohne Brand | (Non-Specific -- Arsenic Compound, Solid, n.o.s.) Keep unnecessary people awayisolate hazard area and deny entry. Stay upwindkeep out of low areas. Do not touch spilled materialstop leak if you can do it without risk. |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Verschüttetes entsorgen | Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations. |
| Isolation and Evacuation | Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]: |
| Eye Prevention | Wear safety goggles or eye protection in combination with breathing protection. |
| Inhalation Risk | Evaporation at 20 °C is negligiblea harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. |
| Skin Prevention | Protective gloves. Protective clothing. |
| Minimum Risk Level | Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134) |
| Treatment | Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20) |
| Gesundheitliche Auswirkungen | Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20) |
| Expositionspfade | The substance can be absorbed into the body by inhalation and by ingestion.Oral (L2)inhalation (L2)dermal (L2) |
| Toxizitätsübersicht | Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17) |
| Signs and Symptoms | Abdominal pain. Confusion. Diarrhoea. Dizziness. Drowsiness. Headache. Vomiting. Incoordination. Paralysis. Symptoms may be delayed.Further see Inhalation.Abdominal pain. Confusion. Diarrhoea. Dizziness. Dullness. Headache. Vomiting. Incoordination. Muscle paralysis. Further see Inhalation.Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1). |
| Human Toxicity Excerpts | Toxic by ingestion. |
| Carcinogen Classification | 3, not classifiable as to its carcinogenicity to humans. (L135) |
| Non-Human Toxicity Excerpts | ACUTE CLINICAL SIGNS AFTER EXPOSURE TO HIGH LEVELS OF PHENYLARSONIC COMPD INCL INCOORDINATION, INABILITY TO CONTROL BODY & LIMB MOVEMENTS, & ATAXIA. AFTER FEW DAYS, SWINE & POULTRY MAY BECOME PARALYZED. ERYTHEMA IN WHITE SKINNED ANIMALS. |
| Toxicity Data | LD50: 270 ug/kg (Oral, Mouse) (T14) LD50: 16 mg/kg (Intravenous, Rabbit) (T14) |
| Non-Human Toxicity Values | LD50 Mouse oral 270 ug/kgLD50 Rabbit iv 16 mg/kg |
| Luftstandards | (a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/ |
| CERCLA-Meldepflichtmengen | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Benzenearsonic acid is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 10 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered for and has a particle size less than 100 micronsor is handled in solution or in molten formor meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... . |
| Clean Water Act Anforderungen | Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/D004A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. |
| Landesrichtlinien für Trinkwasser | (AZ) ARIZONA 10 ug/L /Arsenic/(CT) CONNECTICUT 10 ug/l /Arsenic/ |
| Federal Drinking Water Standards | 10 ug/l /Arsenic/ |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | 3280 |
| Zollcode | 29310099 |
| RTECS-Nr. | CY3150000 |
| R-Sätze (R) | 50/53-23/25 |
| Toxizität | LDLo orl-rat: 50 mg/kg JPETAB 93,287,48 |
| Gefahrensymbole | N-T |
| Sicherheitshinweise (S) | 61-60-45-28A-20/21 |
| Gefahrenklasse | 6.1 |
| Verpackungsgruppe | III |
| Gefahrstoffdaten | 98-05-5(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
Arsonic acids (arsonic acid, phenylarsonic acid, p-hydroxyphenylarsonic acid, arsanilic acid) react with the tetravalent metals of group IV of the periodic system to give water-insoluble complexes of composition MA2 . The composition of the precipitates is not exactly stoichiometric, and hence the precipitates are not suitable for direct gravimetric analysis. Instead, the precipitates are transformed by ignition to the corresponding metal oxides and weighed as such. The main advantage of the application of these reagents is the possibility offered of the selective determination of zirconium(IV), hafnium(IV) and titanium(IV) in the presence of many other metals, such as zinc, manganese, nickel, cobalt, aluminium, copper, calcium, magnesium and chromium. In practice they are utilized most frequently for the determination of zirconium. In strong mineral acidic media phenylarsonic acid forms water-insoluble precipitates with zirconium and hafnium only. In highly concentrated acetic acid solution the thorium phenylarsonate complex is also precipitated, which makes possible the separation of thorium from rare earth metals. The procedure gives satisfactory results in the presence of alkaline earth metals, iron, aluminium, manganese, cobalt, nickel, copper, zinc and bismuth.