4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
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Grundinformationen
- CAS
101574-65-6- Standard-SMILES
CC(C)c1ccc(C=NNC(=O)c2ccc(O)cc2)cc1- Summenformel
- C17H18N2O2
- Durchschnittliche Molmasse
- 282,34 g/mol
Namen und Bezeichner
- Bevorzugter Name
- 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
- Englischer Name
- 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
- Summenformel
- C17H18N2O2
- Molmasse
- 282.34
Namen und Synonyme
CS-1084GSK-4716, 10 mM in DMSOGSK 4716, ERRbetagamma agonist4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazideBenzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide
Datenbank-Bezeichner
- CAS
101574-65-6- PubChem CID
- 739516
- EC Number
- 682-923-4
Eigenschaften
Physikochemische Eigenschaften
- Dichte
- 1.12 · 1.12
- storage temp.
- 2 · Inert atmosphere,2-8°C
- Löslichkeit
- 10 mg/mL · DMSO: >10mg/mL
- Aggregatzustand
- powder
- pka
- 8.48 · 8.48±0.15(Predicted)
- Farbe
- white to off-white
- InChI
- 1S/C17H18N2O2/c1-12(2)14-5-3-13(4-6-14)11-18-19-17(21)15-7-9-16(20)10-8-15/h3-12,20H,1-2H3,(H,19,21)/b18-11+
- InChIKey
- IKPPIUNQWSRCOZ-WOJGMQOQSA-N
- SMILES
- CC(C)c1ccc(cc1)\C=N\NC(=O)c2ccc(O)cc2
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 3077 9 / PGIII
- risk_code
- 43-50/53
- hazard_code
- Xi,N
- safety_code
- 36/37-60-61
- hazard_class
- 9
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Aquatic Acute 1Aquatic Chronic 1Skin Sens. 1
Chemie und Industrie
Anwendungen
BeschreibungThe estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.
VerwendenThe estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.[Cayman Chemical]
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