| GHS-Einstufung | Not ClassifiedAggregated GHS information provided per 736 reports by companies from 13 notifications to the ECHA C&L Inventory. |
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| Regulatorische Informationen | Chemical: Magnesium hydroxide (Mg(OH)2)Magnesium hydroxide (Mg(OH)2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Magnesium hydroxide (Mg(OH)2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Reg. (EU) 2024/836Status: Active Update: 21-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/16073Magnesium hydroxide: Does not have an individual approval but may be used under an appropriate group standard |
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| Weitere Sicherheitsinformationen | IMAP assessments - Magnesium hydroxide (Mg(OH)2): Environment tier I assessment |
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| Gefahrenübersicht | May cause eye injury[HSDB] An eye irritant[eChemPortal: ERMA] Powder irritates eyes[MSDSonline] See Magnesium. |
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| FDA-Anforderungen | This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice.Substance added directly to human food affirmed as generally recognized as safe (GRAS).Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. Magnesium hydroxide is included in digestive aid products.The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed over-the-counter drug products, incl magnesium hydroxide, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.Antacid products for over-the-counter (OTC) human use. Magnesium hydroxide is included on this list of specific active ingredients. |
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| EPA Safer Chemical | Chemical: Magnesium hydroxide |
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| Hazard Classes and Categories | Not Classified |
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| Hazardous Reactivities and Incompatibilities | Phosphorus boiled with alkaline hydroxides yields mixed phosphines which may ignite spontaneously in air. /Alkaline hydroxides/ALKALI & OTHER ALKALINE EARTH COMPD...MAGNESIUM COMPD...CAUSE EXPLOSIVE DECOMP OF MALEIC ANHYDRIDE. |
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| Lagerbedingungen | KEEP WELL CLOSED |
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| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Protective Action Criteria (PAC) | 26 [mg/m3]280 [mg/m3]1700 [mg/m3] |
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| Wechselwirkungen | ...MAGNESIUM HYDROXIDE MAY INTERFERE WITH ABSORPTION OF WARFARIN BY ALKALINIZING GASTROINTESTINAL CONTENTS. ...IT HAS BEEN DEMONSTRATED THAT MAGNESIUM HYDROXIDE SUSPENSION ACTUALLY ENHANCES THE ABSORPTION OF DICUMAROL...HIGHER PEAK SERUM LEVELS...ALKALINIZATION OF URINE CAN DECR EXCRETION OF VARIOUS WEAKLY BASIC DRUGS (EG QUINIDINE). MG(OH2) INCR ABSORPTION OF WARFARIN IN MAN & DECR ABSORPTION OF BARBITURATES IN RATS. |
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| Toxizitätsübersicht | The CIR Expert Panel concluded that ... Magnesium Hydroxide is safe in hair straighteners and depilatories under conditions of recommended useusers should minimize skin contact. These ingredients are safe for all other present practices of use and concentration described in this safety assessment when formulated to be nonirritating.Safe for use in cosmetics, with qualifications |
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| Natural Pollution Sources | OCCURS IN NATURE AS THE MINERAL BRUCITE.OCCURS AS AN ALTERATION PRODUCT OF PERICLASE IN SERPENTINE AND MARBLE AND IN CHLORITE AND DOLOMITE SCHISTS |
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| Human Toxicity Excerpts | /HUMAN EXPOSURE STUDIES/ Compounds with a basic pH are potentially even more damaging to the eye than are strong acids. Among the compounds of clinical significance in terms of frequency and severity of injuries are ... magnesium hydroxide./HUMAN EXPOSURE STUDIES/ IF EVACUATION FAILS (BOWEL OBSTRUCTION OR ATONY), MUCOSAL IRRITATION & ABSORPTION OCCUR. SYSTEMICALLY MG PRODUCES CNS DEPRESSION, ABOLITION OF REFLEXES, & DEATH FROM RESP PARALYSIS./HUMAN EXPOSURE STUDIES/ PROLONGED USE OF MG(OH)2 MAY RARELY CAUSE RECTAL STONES COMPOSED OF MGCO3 & MG(OH)2. |
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| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Acute Exposure/ ...IN DOGS, THE MAGNESIUM CONTENT OF GASTRIC MUCOSA & MUSCULARIS IS INCR & IT IS POSSIBLE THAT THE EFFECT TO DECR ANTRAL MOTILITY & UROPEPSIN SECRETION IS FROM A DIRECT LOCAL ACTION./LABORATORY ANIMALS: Acute Exposure/ ...MILK OF MAGNESIA ON RABBIT EYES...TWICE A DAY FOR THREE OF FOUR DAYS CAUSED DAMAGE TO CORNEAL EPITHELIUM DEMONSTRABLE BY STAINING WITH FLUORESCEIN. AFTER THE APPLICATIONS...WERE DISCONTINUED, CORNEAS RETURNED TO NORMAL IN TWO OR THREE DAYS./LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ The effects of magnesium hydroxide were examined on methylazoxymethanol (MAM) acetate-induced c-myc expression and cell proliferation of colonic mucosal epithelium in rats. Rats were divided into four groups and treated as follows: MAM acetate alone (25 mg/kg i.p. injection, five times, once a week for 5 weeks), MAM acetate and feeding of 0.2% magnesium hydroxide in diet, magnesium hydroxide alone and non-treatment. At 4, 8 and 16 weeks after the start of experiment, 10 rats in each group were sacrificed. Magnesium hydroxide inhibited the MAM-induced expression of c-myc proto-oncogene, and also suppressed the increased bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) labelling indexes induced by MAM acetate in colon mucosa in initiation and post-initiation phase. These results suggest that the anti-carcinogenic effect of magnesium hydroxide on rat colon carcinogenesis induced by MAM acetate may be related to the inhibition of the carcinogen-induced expression of c-myc proto-oncogene and cell proliferation./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Preventive effect of magnesium hydroxide on carcinogen-induced, large bowel carcinogenesis was examined in three experiments using F344 rats. Experiment I: Rats received dietary administration of magnesium hydroxide at concentrations of 500 or 1,000 ppm after treatment with methylazoxymethanol (MAM) acetate (25 mg/kg, 3 times). These rats had a lower incidence of large bowel neoplasms than animals given MAM acetate alone. Reduction of the tumor incidence was especially significant at a dose of 500 ppm. Experiment II: Rats given magnesium hydroxide (250, 500, or 1,000 ppm) together with 1,2-dimethylhydrazine (DMH) (20 mg/kg, 10 times) showed a lower multiplicity of large bowel tumors than those given DMH alone. Experiment III: The labeling indices of the cryptal cells of the large bowel (cecum or proximal colon or distal colon) or rates given magnesium hydroxide for 4, 6, or 8 weeks after treatment with MAM acetate (25 mg/kg, 3 times) were smaller than those of animals given MAM acetate alone, indicating that magnesium hydroxide suppressed, carcinogen-induced epithelial cell (large bowel) proliferation. The results of the three experiments suggest that magnesium, one of the essential metals, is a promising chemopreventive agent in humans. |
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| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
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| Non-Human Toxicity Values | LD50 Rat oral 8500 mg/kgLD50 Rat intraperitoneal 2780 mg/kg |
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