Magnesiumhydroxid

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

26 [mg/m3]

280 [mg/m3]

1700 [mg/m3]

...MAGNESIUM HYDROXIDE MAY INTERFERE WITH ABSORPTION OF WARFARIN BY ALKALINIZING GASTROINTESTINAL CONTENTS. ...IT HAS BEEN DEMONSTRATED THAT MAGNESIUM HYDROXIDE SUSPENSION ACTUALLY ENHANCES THE ABSORPTION OF DICUMAROL...HIGHER PEAK SERUM LEVELS...

ALKALINIZATION OF URINE CAN DECR EXCRETION OF VARIOUS WEAKLY BASIC DRUGS (EG QUINIDINE). MG(OH2) INCR ABSORPTION OF WARFARIN IN MAN & DECR ABSORPTION OF BARBITURATES IN RATS.

The CIR Expert Panel concluded that ... Magnesium Hydroxide is safe in hair straighteners and depilatories under conditions of recommended use; users should minimize skin contact.  These ingredients are safe for all other present practices of use and concentration described in this safety assessment when formulated to be nonirritating.

Safe for use in cosmetics, with qualifications

OCCURS IN NATURE AS THE MINERAL BRUCITE.

OCCURS AS AN ALTERATION PRODUCT OF PERICLASE IN SERPENTINE AND MARBLE AND IN CHLORITE AND DOLOMITE SCHISTS

/HUMAN EXPOSURE STUDIES/ Compounds with a basic pH are potentially even more damaging to the eye than are strong acids. Among the compounds of clinical significance in terms of frequency and severity of injuries are ... magnesium hydroxide.

/HUMAN EXPOSURE STUDIES/ IF EVACUATION FAILS (BOWEL OBSTRUCTION OR ATONY), MUCOSAL IRRITATION & ABSORPTION OCCUR. SYSTEMICALLY MG PRODUCES CNS DEPRESSION, ABOLITION OF REFLEXES, & DEATH FROM RESP PARALYSIS.

/HUMAN EXPOSURE STUDIES/ PROLONGED USE OF MG(OH)2 MAY RARELY CAUSE RECTAL STONES COMPOSED OF MGCO3 & MG(OH)2.

/LABORATORY ANIMALS: Acute Exposure/ ...IN DOGS, THE MAGNESIUM CONTENT OF GASTRIC MUCOSA & MUSCULARIS IS INCR & IT IS POSSIBLE THAT THE EFFECT TO DECR ANTRAL MOTILITY & UROPEPSIN SECRETION IS FROM A DIRECT LOCAL ACTION.

/LABORATORY ANIMALS: Acute Exposure/ ...MILK OF MAGNESIA ON RABBIT EYES...TWICE A DAY FOR THREE OF FOUR DAYS CAUSED DAMAGE TO CORNEAL EPITHELIUM DEMONSTRABLE BY STAINING WITH FLUORESCEIN. AFTER THE APPLICATIONS...WERE DISCONTINUED, CORNEAS RETURNED TO NORMAL IN TWO OR THREE DAYS.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ The effects of magnesium hydroxide were examined on methylazoxymethanol (MAM) acetate-induced c-myc expression and cell proliferation of colonic mucosal epithelium in rats. Rats were divided into four groups and treated as follows: MAM acetate alone (25 mg/kg i.p. injection, five times, once a week for 5 weeks), MAM acetate and feeding of 0.2% magnesium hydroxide in diet, magnesium hydroxide alone and non-treatment. At 4, 8 and 16 weeks after the start of experiment, 10 rats in each group were sacrificed. Magnesium hydroxide inhibited the MAM-induced expression of c-myc proto-oncogene, and also suppressed the increased bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) labelling indexes induced by MAM acetate in colon mucosa in initiation and post-initiation phase. These results suggest that the anti-carcinogenic effect of magnesium hydroxide on rat colon carcinogenesis induced by MAM acetate may be related to the inhibition of the carcinogen-induced expression of c-myc proto-oncogene and cell proliferation.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Preventive effect of magnesium hydroxide on carcinogen-induced, large bowel carcinogenesis was examined in three experiments using F344 rats. Experiment I: Rats received dietary administration of magnesium hydroxide at concentrations of 500 or 1,000 ppm after treatment with methylazoxymethanol (MAM) acetate (25 mg/kg, 3 times). These rats had a lower incidence of large bowel neoplasms than animals given MAM acetate alone. Reduction of the tumor incidence was especially significant at a dose of 500 ppm. Experiment II: Rats given magnesium hydroxide (250, 500, or 1,000 ppm) together with 1,2-dimethylhydrazine (DMH) (20 mg/kg, 10 times) showed a lower multiplicity of large bowel tumors than those given DMH alone. Experiment III: The labeling indices of the cryptal cells of the large bowel (cecum or proximal colon or distal colon) or rates given magnesium hydroxide for 4, 6, or 8 weeks after treatment with MAM acetate (25 mg/kg, 3 times) were smaller than those of animals given MAM acetate alone, indicating that magnesium hydroxide suppressed, carcinogen-induced epithelial cell (large bowel) proliferation. The results of the three experiments suggest that magnesium, one of the essential metals, is a promising chemopreventive agent in humans.

LD50 Rat oral 8500 mg/kg

LD50 Rat intraperitoneal 2780 mg/kg

This substance is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. Magnesium hydroxide is included in digestive aid products.

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed over-the-counter drug products, incl magnesium hydroxide, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.

Antacid products for over-the-counter (OTC) human use. Magnesium hydroxide is included on this list of specific active ingredients.

CIR ingredient: Magnesium Hydroxide

Found naturally as brucite; [Hawley] Used to make magnesium metal and compounds (dead-burned and caustic-burned magnesia and magnesium oxide, chloride, carbonate, and sulfate), and as an antacid and laxative, a clarifier in sugar refining, and as a residual fuel oil additive; Also used for uranium processing, wastewater treatment, sulfur dioxide removal from waste gases, and neutralization of acids in the chemical industry; Also used in toothpastes and dentrifrices, in foods as a drying and color-retention agent, in frozen desserts, in the pulp and paper industries, and in other products (ceramics, pharmaceuticals, plastics, and flame retardants/smoke suppressants); [HSDB] Used as an alkali and color adjunct; [JECFA]

Metal Preparation and Pouring [Category: Foundry]

Ceramics making [Category: Hobbies]

CHEM INT FOR DEAD-BURNED & CAUSTIC-BURNED MAGNESIA, MAGNESIUM CHLORIDE & MAGNESIUM CARBONATE; RAW MATERIAL FOR MAGNESIUM METAL; INGREDIENT IN TOOTHPASTE; NEUTRALIZATION OF ACIDS IN THE CHEMICAL INDUSTRY; ... CLARIFIER IN SUGAR REFINING

RESIDUAL FUEL OIL ADDITIVE; SULFITE PULP; URANIUM PROCESSING; DENTRIFRICES; IN FOODS AS DRYING AGENT, COLOR RETENTION AGENT; FROZEN DESSERTS

2023: 400,000,000 - <550,000,000 lb

(1974) 8.46X10+10 GRAMS (USE)

REACTION OF CALCIUM HYDROXIDE WITH SEA WATER WHICH HAS BEEN PURIFIED TO REMOVE COLLOIDAL PARTICLES, CARBON DIOXIDE, AND SALTS OF OTHER METALS

...FROM MAGNESIUM CHLORIDE OR SULFATE & SODIUM HYDROXIDE...US 3127241 (1964 TO DOW). INDUSTRIAL METHOD FOR PRODUCING MAGNESIUM HYDROXIDE HAVING VARIABLE PARTICLE SIZES...US 3232708 (1966 TO FMC).

Precipitation from a solution of a magnesium salt by sodium hydroxide or precipitation from seawater with lime.

Dead Sea Periclase (DSP, Mishor Rotem, Israel) converts magnesium chloride into MgO by spray-roasting, then hydrates the MgO to Mg(OH)2.

Magnesite is acidified to produce MgCl2 and subsequent MgO of 99% purity, which is converted to magnesium hydroxide by hydration.

MILK OF MAGNESIA USP, IS AN AQUEOUS SUSPENSION OF MAGNESIUM HYDROXIDE CONTAINING 7.0-8.5% OF MG(OH)2. EACH MILLILITER IS CAPABLE OF NEUTRALIZING APPROX 2.7 MEQ OF ACID. ...MAGNESIUM HYDROXIDE IS ALSO AVAIL AS MAGNESIA TABLETS...GENERALLY CONTAIN 325 MG EACH, WHICH CAN NEUTRALIZE 11.2 MEQ OF ACID.

USP; 250 ML & 500 ML BOTTLES WITH ALUMINUM HYDROXIDE GEL; 250 ML, 375 ML, 500 ML & 1 L BOTTLES.

SUSPENSION OF 30% MAGNESIUM HYDROXIDE IN WATER: HYDRO-MAGMA.

MAGNESIUM HYDROXIDE DRUG AVAILABLE GENERICALLY: POWDER; TABLETS 300 & 600 MG.

For more Formulations/Preparations (Complete) data for MAGNESIUM HYDROXIDE (9 total), please visit the HSDB record page.

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Food additives

Food Additives -> ACIDITY_REGULATOR; COLOUR_RETENTION_AGENT -> JECFA Functional Classes

Cosmetics -> Buffering; Absorbent

Plastics -> Polymer Type -> Polyolefin-I; Polyolefin-II; ABS

Mining (except Oil and Gas) and support activities

Magnesium hydroxide (Mg(OH)2): ACTIVE

INCOMPATIBILITIES: ...HAS AN ALKALINE REACTION & POSSESSES INCOMPATIBILITIES TYPICAL OF SUCH REACTION. THUS, ALKALOIDS ARE LIBERATED FROM SOLN OF THEIR SALTS. /MILK OF MAGNESIA USP/

...HIGH NEUTRALIZING CAPACITY WITH RAPID ONSET... AS WITH ALL AMPHOTERIC ANTACIDS, TABLETS ARE LESS EFFECTIVE THAN LIQUID PREPARATIONS.

MAGNESIUM HYDROXIDE IS DISPERSED IN WATER CONTAINING SODIUM POLYMETHACRYLATE TO PRODUCE A HIGHLY CONCENTRATED MAGNESIUM HYDROXIDE SLURRY OF LOW VISCOSITY FOR WASTE GAS DESULFURIZATION.

Unlike other magnesium hydroxide products, the Mg(OH)2 in milk of magnesia is produced from basic magnesium carbonate. The fine particle structure formed in this reaction makes milk of magnesia a stable slurry.