1-Methyl-4-piperidon

1-Methyl-4-piperidone

HCID 74049CAS 1445-73-4
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Grundinformationen

Standard-SMILES
CN1CCC(=O)CC1
InChIKey
HUUPVABNAQUEJW-UHFFFAOYSA-N
Summenformel
C6H11NO
Durchschnittliche Molmasse
113,16 g/mol
Monoisotopische Masse
113,08406397

Namen und Bezeichner

Bevorzugter Name
1-Methyl-4-piperidone
IUPAC
1-methylpiperidin-4-one
Lokaler Name
1-Methyl-4-piperidon
Englischer Name
1-Methyl-4-piperidone
Summenformel
C6H11NO
Molmasse
113.16

Namen und Synonyme

1-Methyl-4-piperidone1445-73-41-Methyl-4-piperidinone4-PIPERIDINONE, 1-METHYL-NSC-66491W923NR2QCSDTXSID20162735RefChem:76331DTXCID2085226215-895-51-methylpiperidin-4-oneN-Methyl-4-piperidone
Weitere Namen anzeigen
N-METHYLPIPERIDONEN-METHYLPIPERIDIN-4-ONEN-METHYL-GAMMA-PIPERIDONE1-METHYLTETRAHYDROPYRIDIN-4(1H)-ONENSC 66491AKOS BBS-00004237
4-Piperidone, 1-methyl-N-Methyl-4-piperidinone1-Methyl-4-oxopiperidineMFCD000061911-Methyl-4-piperidioneDomperidone Impurity 251-Methylpiperidine-4-one1-methyl-piperidin-4-one

Datenbank-Bezeichner

CAS
1445-73-4
PubChem CID
74049
DTXSID
DTXSID20162735
UNII
W923NR2QCS
EC Number
215-895-5
Nikkaji
J86.542G

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-0,3
Polarare Oberfläche (TPSA)
20,3 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
0
Schwere Atome
8

Experimentelle und physikochemische Eigenschaften

Physical DescriptionClear dark yellow liquid; [Sigma-Aldrich MSDS]

Physikochemische Eigenschaften

Schmelzpunkt
192 · 192-193 °C(Solv: ethyl acetate (141-78-6))
Siedepunkt
55 · 55-60 °C11 mm Hg(lit.)
Dichte
0.92 g/mL · 0.92 g/mL at 25 °C (lit.)
Brechungsindex
20 · n20/D 1.460
Flammpunkt
140 °F · 140 °F
storage temp.
30 °C · Store below +30°C.

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

Danger

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]；H314 (10.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 84 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory Information · 3 Einträge

Chemical: 4-Piperidinone, 1-methyl-

Status: Active Update: 04-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/22575

1-Methyl-4-piperidinone: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS] See 1-Benzyl-4-piperidone.
Hazard Classes and CategoriesFlam. Liq. 3 (100%)；Skin Corr. 1B (10.7%)

Regulatorische Informationen

Regulatory Information · 3 Einträge

Chemical: 4-Piperidinone, 1-methyl-

Status: Active Update: 04-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/22575

1-Methyl-4-piperidinone: Does not have an individual approval but may be used under an appropriate group standard

Sicherheitsdaten

wgk
3
ridadr
UN 1224 3/PG 3
hs_code
29333999
risk_code
34-10-36/37/38
hazard_code
C,Xi
hazard_note
Irritant

Chemie und Industrie

Anwendungen · 1 Eintrag

Verwenden1-Methyl-4-piperidone, are widely used in artificial fibre industry. They are polymerizable and used as nylon precursors. They have excellent applications as solvents and as intermediates for organic synthesis. They are used in the aqueous carrier medium and amide penetrants in inks and water soluble paints.

Darstellung · 1 Eintrag

synthetische[JACS (1948) vol 70 p 1820] for the synthesis of 1-methyl-4-piperidone: To a one-liter flask containing 350 ml of 20 % hydrochloric acid was added 86 g. of 1-methyl-3-carbethoxy-4-piperidone hyrdrochloride. After refluxing for one hour, the ferric chloride reagent gave no coloration. The solution was evaporated to dryness on a steam-bath at 10 mm. pressure. The solid product, heated at 100 °C for 4 hours at 0.1 mm and further dried over solid KOH for 24 hours, weighed 57.7 g, m.p. 80 - 120 °C.Although this melting range goes above that of the pure comound 0.45 of crude material dissolved in 90 ml. of hot acetone gave 0.40 g of pure compoundd melting at 93 - 95 °C. Other samples of crude piperidone hydrochloride showed even higher melting points than the one mentioned above, yet this apperently impure material always gave good yields of sharp melting product when recrystallized.

Vor- und nachgelagerte Produkte

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国药集团化学试剂有限公司86-21-63210123 · [email protected]
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衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海泰矶林实业有限公司02150630626 17717886015 · [email protected]

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