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1,3-Dinitrobenzol
M-DINITROBENZENE · m-dnb · meta-dinitrobenzene · 2,4-Dinitrobenzene · 1,3-DNB · nsc-7189 · 1.3-Dinitr · Binitrobenzene
Identifikatoren & physikalische Daten
| CAS No. | 99-65-0 |
|---|---|
| Summenformel | C6H4N2O4 |
| Durchschnittliche Molmasse | 168,11 g/mol |
| Monoisotopische Masse | 168,01710661 g/mol |
| SMILES | O=[N+]([O-])c1cccc([N+](=O)[O-])c1 |
| InChIKey | WDCYWAQPCXBPJA-UHFFFAOYSA-N |
| PubChem CID | 7452 |
| ChEMBL | CHEMBL114070 |
| ChEBI | CHEBI:51397 |
| EC No. | 202-776-8 |
| DTXSID | DTXSID9024065 |
| Lokaler Name | 1,3-Dinitrobenzol |
Chemische & physikalische Eigenschaften
| XLogP | 1,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 91,6 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 12 |
| Formalladung | 0 |
| Komplexität | 175 |
| Stoffklassen | Nitrogen Compounds -> Nitros, AromaticReactive agents - 4th degree |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| SpringerMaterials Properties | 13C nuclear magnetic resonance spectrum |
| Pestizide | Pesticide -> EPA IRIS |
| LogP (Verteilungskoeffizient) | log Kow= 1.49 |
| Dichte | 1.58 at 64.4 °F (USCG, 1999) - Denser than waterwill sink1.575 @ 18 °C/4 °C1.6 g/cm³1.5751 @ 18°C |
| Color/Form | Yellowish crystalsColorless to yellow, rhombic needles or platesPale white or yellow, crystalline solid. |
| Löslichkeit | 0.02 % (NIOSH, 2024)1 g dissolves in 2000 ml cold water, 320 ml boiling water1 g dissolves in 37 ml alcohol, 20 ml boiling alcoholfreely sol in chloroform, ethyl acetateVery soluble in acetone and ethanolsoluble in etherIn water, 533 mg/l @ 25 °CSolubility in water: very poor0.02%Chloroform (Sparingly), DMSO (Slightly), Methanol (Very Slightly)500 mg/L (20 ºC) |
| Corrosivity | Liquid dinitrobenzene will attack some forms of plastics, rubber, and coatings. /Dinitrobenzene, all isomers/ |
| Flammpunkt | 302 °F (NIOSH, 2024)302 °F (CLOSED CUP)149 °C150 °C |
| Siedepunkt | 556 °F at 756 mmHg (NTP, 1992)302.8 °C @ 770 mm Hg300-303 °C291 °C @760 [mm Hg]572 °F297 °C(lit.) |
| Decomposition | When heated to decomposition it emits toxic fumes of /nitrogen oxides/. |
| Schmelzpunkt | 86 °C |
| Dampfdruck | 8.15 x 10-4 mmHg at 35 °C (Hine et al., 1963) |
| Brechungsindex | 1.4660 (estimate) |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | solid |
| Wichte | 1.368 |
| Farbe | White to yellowish crystals |
| Spezifische Wärmekapazität | Cp(crystal): 1.17 J/(g·K), at 25℃ |
| Merck | 14,3273 |
| BRN | 1105654 |
| Henry-Konstante | 1.8×102 mol/(m3Pa) at 25℃, Chao et al. (2017) |
| Dielektrizitätskonstante | 2.8(20.0℃) |
| Stabilität | Stable. Incompatible with reducing agents, oxidizing agents, strong bases. May explode if heated. |
| Hauptanwendungen | environmental |
| InChI | 1S/C6H4N2O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H |
| InChIKey | WDCYWAQPCXBPJA-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1cccc(c1)[N+]([O-])=O |
| CAS Datenbank | 99-65-0(CAS DataBase Reference) |
| NIST chemische Informationen | Benzene, 1,3-dinitro-(99-65-0) |
| EPA chemische Informationen | m-Dinitrobenzene (99-65-0) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH300: Fatal if swallowed [Danger Acute toxicity, oral]P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P319, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] |
|---|---|
| Regulatorische Informationen | Chemical: Benzene, 1,3-dinitro-Hazard Traits - NeurotoxicityReproductive Toxicity1,3-Dinitrobenzene: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| DOT-Kennzeichnung | Poison |
| Brandgefahren | Behavior in Fire: May explode (USCG, 1999)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air. |
| Brandpotenzial | Combustible |
| Gesundheitsgefahren | Inhalation or ingestion causes loss of color, nausea, headache, dizziness, drowsiness, and collapse. Eyes are irritated by liquid. Stains skin yellowif contact is prolonged, can be absorbed into blood and cause same symptoms as for inhalation. (USCG, 1999) |
| Gefahrenübersicht | Methemoglobinemia, liver injury, and visual impairment (central scotomas) have been reported in exposed workers. Listed in table of Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity[ACGIH] m-Dinitrobenzene was eliminated from in vitro testing after little response was detected, even at high concentrations. [French CL et al. Potency ranking of methemoglobin-forming agents. J Appl Toxicol. 15(3):167-74 (1995).]An eye and respiratory tract irritantCan induce methemoglobinemia and have effects on the liver[ICSC]The major hazards encountered in the use and handling of 1,3-dinitrobenzene stem from its toxicologic properties and explosivity. Toxic by all routes (ie, inhalation, ingestion, dermal absorption), exposure to this yellowish, crystalline substance may occur from its use in the production of analine, dyes, explosives, industrial solvents, and pesticides. Effects from exposure mayinclude contact burns to the skin and eyes, headache, nausea, lethargy, heart palpitations, methemoglobinemia, jaundice, and respiratory failure. Effects may be delayed up to 1-4 hours. OSHA has established an 8 hour, Time Weighted Average (TWA) limit of 1 mg/cu m, with a skin designation for this substance. In activities and situations where over-exposure may occur, wear a positive pressure self-contained breathing apparatus and chemical protective clothing which is specifically recommended by the shipper or manufacturer. If contact should occur, irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes and wash exposed skin thoroughly with soap and water. Contaminated clothing should be removed and discarded or left at the site for cleaning before being reworn. 1,3-Dinitrobenzene is a severe explosion hazard when exposed to friction, mechanical shock, localized thermal shock, or contamination. For fires involving 1,3-dinitrobenzene, extinguish with dry chemical, CO2, water spray, fog, or standard foam. Fight the fire from as far a distance as possible in an explosion-resistant location. If fire is massive, back off, protect surroundings, and let burn. 1,3-Dinitrobenzene may be transported via air, rail, road, and water, in containers bearing the label, "Poison." 1,3-Dinitrobenzene should be stored in a permanent magazine, away from heat, sources of ignition, sources of physical damage, oxidizers, combustibles, caustics, and metals such as tin and zinc. For small spills of 1,3-dinitrobenzene, use a clean shovel to place material into clean, dry, covered containers for later disposal (liquid solutions are taken up with sand or other noncombustible absorbent). Dike far ahead of large liquid spills to prevent runoff. Large dry spills should be covered with plastic sheeting. Large spills into bodies of water should be trapped at the bottom with sand bag barriers, apply activated carbon, and use mechanical dredges or lifts to remove immobilized masses. |
| DOT-Nummer und Handbuch | 1597 152 |
| Reaktive Gruppe | Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic |
| EG-Einstufung | Symbol: T+, NR: 26/27/28-33-50/53S: (1/2)-28-36/37-45-60-61Note: C |
| UN-Einstufung | UN Hazard Class: 6.1UN Pack Group: II |
| Special Reports | Dangerous Prop Ind Mater Rep 6 (1): 49-52 (1986). Review dinitrobenzene safety toxicolHealth hazard of dinitrobenzene.AnonymousJ Appl Toxicol 9 (3): 199-202 (1989). Toxicology update for dinitrobenzene with 42 references on toxicity, metabolism, teratogenicity, mutagenicity, and carcinogenicity.U.S. Dept Health & Human Services/Agency for Toxic Substances Disease RegistryToxicological Profile for 1,3-Dinitrobenzene/1,3,5-Trinitrobenzene (1995) NTIS # PB/95/264289/ASDHHS/ATSDRToxicological Profile for 1,3-Dinitrobenzene and 1,3,5-Trinitrobenzene (June 1995) |
| TSCA-Anforderungen | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. m-Dinitrobenzene is included on this list. |
| Brandbekämpfung | Fire Extinguishing Agents: Water from protected location (USCG, 1999)Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.(General first aid procedures) |
| Sichere Lagerung | Separated from strong oxidants, strong bases and food and feedstuffs. See Chemical Dangers. |
| Expositionsschutz und Persönliche Schutzausrüstung | Biological Exposure Indices (BEI) [ACGIH] - Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
| Brandbekämpfungsverfahren | Fire Fighting Respirator: Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode. |
| Reinigungsverfahren | 1. Remove all ignition sources. 2. Ventilate area of spill. 3. For small quantities, sweep onto paper or other suitable material & burn in a suitable combustion chamber which allows burning in an unconfined condition & is equipped with an appropriate effluent gas cleaning device. Large quantities may be reclaimedhowever, if this is not practical, dissolve in fuel oil & atomize in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.1. By making packages of dinitrobenzene in paper or other flammable material & burning in a suitable combustion chamber which allows burning in an unconfined condition & is equipped with an appropriate effluent gas cleaning device. 2. By dissolving dinitrobenzene in fuel oil & atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.Dissolve in combustible solvent such as alcohols, benzene, etc. Spray the solution into the furnace with afterburner and scrubber.The following wastewater treatment technologies have been investigated for dinitrobenzene: Concentration process: Reverse osmosis. /Dinitrobenzene/ |
| Verschüttetes entsorgen | Consult an expert! Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus. |
| Preventive Measures | Eating and smoking should not be permitted in areas where dinitrobenzene or liquids containing dinitrobenzene are handled, processed, or stored. Employees who handle dinitrobenzene or liquids containing dinitrobenzene should wash their hands thoroughly with soap or mild detergent and water before eating, smoking, or using toilet facilities.Protect containers against physical damage. Keep away from heat and sources of ignition or acute fire hazard area. Storage area should be equipped with an automatic sprinkler system if within a building.Clothing contaminated with dinitrobenzene should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of dinitrobenzene from the clothing.If employees' clothing becomes contaminated with solid dinitrobenzene, employees should change into uncontaminated clothing before leaving the work premises. ... If the clothing is to be laundered or otherwise cleaned to remove the dinitrobenzene, the person performing the operation should be informed of dinitrobenzene's hazardous properties.For more Preventive Measures (Complete) data for 1,3-DINITROBENZENE (12 total), please visit the HSDB record page. |
| Isolation and Evacuation | Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: |
| Treatment | Treatment is mainly symptomatic and may include gastric lavage and/or the administration of activated charcoal. Benzodiazepine may be administered if seizures occur. If methemoglobinemia is evident, 1 to 2 mg/kg of 1% methylene blue should be administered via IV. (T36) |
| Wechselwirkungen | IN SUBACUTE POISONING, SYMPTOMS MAY BE PRECIPITATED BY SUNLIGHT OR BY INGESTION OF ALCOHOL. /DINITROBENZENE/ |
| Zielorgane | ImmuneEyes, skin, blood, liver, cardiovascular system, central nervous system |
| Gesundheitliche Auswirkungen | Chronic exposure to 1,3-dinitrobenzene can cause a reduction (or loss) in the number of red blood cells (anemia). It may also cause behavioral changes and male reproductive system damage. (L199) |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 150(SRC), determined from a measured log Kow of 1.49(2) and a regression-derived equation(3), indicates that 1,3-dinitrobenzene is expected to have high mobility in soil(SRC). It has been shown that nitrophenols and nitrobenzenes adsorb strongly to clay surfaces and the mobility of 1,3-dinitrobenzene is expected to be low in soils rich in clay content(4,5). Volatilization of 1,3-dinitrobenzene from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 4.9X10-8 atm-cu m/mole(6). 1,3-Dinitrobenzene is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2X10-4 mm Hg(6). More than 64 days were required to biodegrade 1,3-dinitrobenzene in an aqueous biodegradation screening test using a silt loam inoculum at 25 °C(7), which suggests biodegradation will occur slowly in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 150(SRC), determined from a measured log Kow of 1.49(2) and a regression-derived equation(3), indicates that 1,3-dinitrobenzene is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected to be an important fate process(3) based upon a Henry's Law constant of 4.9X10-8 atm-cu m/mole(4). According to a classification scheme(5), BCF values of 2-75 measured in fish(6,7), suggests bioconcentration in aquatic organisms is low to moderate (SRC). The half-life of 1,3-dinitrobenzene in water from the Tennessee River, 1 mile downstream from a munitions plant, was 1 day(8). However, 1,3-dinitrobenzene did not biodegrade in pristine water from rivers and creeks in Maryland(8), suggesting that biodegradation may occur rapidly in acclimated environments, but slowly under non-acclimated conditions(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,3-dinitrobenzene, which has a vapor pressure of 2X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist in the vapor phase in the ambient atmosphere. Vapor-phase 1,3-dinitrobenzene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 526 days(SRC), calculated from its rate constant of 3X10-14 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). 1,3-Dinitrobenzene absorbs light greater than 290 nm and may be susceptible to direct photolysis(4), but the kinetics of this reaction are unknown(SRC). |
| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Expositionspfade | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contactOral (L199)inhalation (L199)dermal (L199) |
| Toxizitätsübersicht | In the red blood cell, 1,3-DNB induces formation of methemoglobin, leading to cyanosis. Reduction of the nitrogroup(s) of 1,3-DNB produces reactive nitroaromatic radical anions which redox cycle to produce other reactive, toxic species such as superoxide anion. Redox cycling of these intermediates probably causes the methemoglobinemia. In the male reproductive system, 1,3-DNB causes disruption of spermatogenesis resulting in hypospermia, poor sperm quality, and infertility. Reduction of 1,3-DNB to reactive species such as nitrosonitrobenzene is believed to damage Sertoli cells. (L199) |
| Signs and Symptoms | Burning sensation. Blue lips, fingernails and skin. Dizziness. Headache. Nausea. Weakness. Laboured breathing.MAY BE ABSORBED! See Inhalation.Redness. Pain.Anoxia, cyanosisvisual disturbance, central scotomasbad taste, burning mouth, dry throat, thirstyellowing hair, eyes, skinanemialiver damageExposure to high concentrations of 1,3-dinitrobenzene can reduce the ability of blood to carry oxygen and can cause your skin to become bluish in color. Other symptoms of 1,3-dinitrobenzene exposure include headache, nausea, and dizziness.(L199) |
| Effluent Concentrations | The concentration of 1,3-dinitrobenzene in an extract of effluent water from organics and plastics industries was 1,055 ng/ul(1). 1,3-Dinitrobenzene has been detected in the effluent of facilities that produce 2,4,6-trinitrotoluene (TNT) at a concn of 4 ppm(2). |
| ICSC Environmental Data | The substance is toxic to aquatic organisms. |
| EPA IRIS Information | m-DinitrobenzeneImmune1 x 10 ^-4 mg/kg-day |
| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| Clean Water Act Anforderungen | m-Dinitrobenzene is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. |
| Landesrichtlinien für Trinkwasser | (FL) FLORIDA 50 ug/l(ME) MAINE 0.7 ug/l |
| Bundesrichtlinien für Trinkwasser | EPA 1 ug/l |
| Berufliche Expositionsstufe (OEB) | C |
| Arbeitsplatzgrenzwert (OEL) | TWA: 1 mg/m3 [skin] |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 3443 6.1/PG 2 |
| Zollcode | 29042090 |
| RTECS-Nr. | CZ7350000 |
| R-Sätze (R) | 26/27/28-33-50/53-40-36/37/38-23/24/25-11-52/53-36-20/21/22 |
| Toxizität | LD50 in male, female rats (mg/kg): 91, 81 orally (Cody) |
| Gefahrensymbole | T+,N,T,F,Xn |
| Sicherheitshinweise (S) | 28-36/37-45-60-61-28A-27-16-26 |
| Gefahrenklasse | 6.1Acute Tox. 1 DermalAcute Tox. 2 InhalationAcute Tox. 2 OralAquatic Acute 1Aquatic Chronic 1STOT RE 2 |
| Verpackungsgruppe | II |
| Lagerklasse | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| Gefahrstoffdaten | 99-65-0(Hazardous Substances Data) |
Anwendungen & Verwendung
Beschreibung
1,3-Dinitrobenzene (1,3-DNB) is an impurity present in the manufacture of 2,4,6-trinitrotoluene. Workers in munitions plants are at risk of exposure. While it does not bioaccumulate, it persists in the environments (air, water, and soil) with slow rates of degradation. Metabolism in animals (rabbits) results in reduction of the nitro functionalities to amine functionalities to produce 2,4-diaminophenol, m-nitroaniline, m-phenylenediamine, and 2-amino-4-nitrophenol. Human exposure is generally dermal contact or inhalation of vapor.
Verwenden
1,3-Dinitrobenzene (1,3-DNB) is an impurity present in the manufacture of 2,4,6-trinitrotoluene. Dinitrobenzene (as a mixture of 1,2-dinitro- 1,3-dinitro- and 1,4-dinitro-isomers) is used in the manufacture of dyes and explosives, and in organic syntheses.
Herstellung & Synthese
synthetische
1,3-Dinitrobenzene is accessible by nitration of nitrobenzene. The reaction proceeds under acid catalysis using sulfuric acid. The directing effect of the nitro group of nitrobenzene leads to 93% of the product resulting from nitration at the meta-position. The ortho- and para-products occur in only 6% and 1%, respectively.