2-Acetylthioethyltrimethyl-ammoniumiodid

Acetylthiocholine iodide

HCID 74629CAS 1866-15-5
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Grundinformationen

Standard-SMILES
CC(=O)SCC[N+](C)(C)C.[I-]
InChIKey
NTBLZMAMTZXLBP-UHFFFAOYSA-M
Summenformel
C7H16INOS
Durchschnittliche Molmasse
289,18 g/mol
Monoisotopische Masse
288,99973

Namen und Bezeichner

Bevorzugter Name
Acetylthiocholine iodide
IUPAC
2-acetylsulfanylethyl(trimethyl)azanium iodide
Lokaler Name
2-Acetylthioethyltrimethyl-ammoniumiodid
Englischer Name
Acetylthiocholine iodide
Summenformel
C7H16INOS
Molmasse
289.18

Namen und Synonyme

Acetylthiocholine iodide1866-15-5S-Acetylthiocholine iodide2-Acetylthioethyltrimethylammonium iodide6SKH6P4YRNNSC-44139Ethanaminium, 2-(acetylthio)-N,N,N-trimethyl-, iodide (1:1)DTXSID50883764RefChem:109203DTXCID701023254217-474-1Acetylthiocholine diiodide
Weitere Namen anzeigen
Acetylthiocholine ioAcetylthiocholinjodidacetylthiocholine iodieKamovsky-roots solutionIodine thioacetylcholineIodide thioacetylcholines-acetylthio-choliniodideacetylthiocholinediiodideacethylthiocholine iodide
Ethanaminium, 2-(acetylthio)-N,N,N-trimethyl-, iodideMFCD000118192-(Acetylthio)-N,N,N-trimethylethanaminium iodideC7H16INOSNSC 44139(2-Mercaptoethyl)trimethylammonium iodide acetate((2-Mercaptoethyl)trimethylammonium iodide acetate)2-(Acetylthio)-N,N,N-trimethylethan-1-aminium iodide

Datenbank-Bezeichner

CAS
1866-15-5
PubChem CID
74629
DTXSID
DTXSID50883764
UNII
6SKH6P4YRN
EC Number
217-474-1

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
42,4 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
3
Frei drehbare Bindungen
4
Schwere Atome
11

Physikochemische Eigenschaften

Schmelzpunkt
205 · 205-210 °C(lit.)
Dichte
1.4885 · 1.4885 (estimate)
storage temp.
2 · 2-8°C
Löslichkeit
2 O: · H2O: 100 mg/mL
Aggregatzustand
powder
Farbe
white

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]；H311 (97.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]；H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (95.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Chemical: Ethanaminium, 2-(acetylthio)-N,N,N-trimethyl-, iodide

2-Acetylthioethyltrimethylammonium iodide: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesAcute Tox. 3 (100%)；Acute Tox. 3 (97.9%)；Skin Irrit. 2 (97.9%)；Eye Irrit. 2 (97.9%)；STOT SE 3 (95.8%)

Regulatorische Informationen

Regulatory Information · 2 Einträge

Chemical: Ethanaminium, 2-(acetylthio)-N,N,N-trimethyl-, iodide

2-Acetylthioethyltrimethylammonium iodide: Does not have an individual approval but may be used under an appropriate group standard

Sicherheitsdaten

F
3-8-10
wgk
3
tsca
TSCA listed
ridadr
UN 2811 6.1/PG 3
hs_code
29309099
RTECS-Nr.
FZ9865000

Chemie und Industrie

Verwendung und Herstellung

General Manufacturing InformationEthanaminium, 2-(acetylthio)-N,N,N-trimethyl-, iodide (1:1): ACTIVE
Anwendungen · 2 Einträge

BeschreibungAcetylthiocholine iodide, also known as ATCI, serves as both an acetylcholinesterase (AChE) substrate and a nicotinic acetylcholine receptor (AChR) agonist. ATCI itself is a colorless and odorless compound. It exhibits solubility in both water and ethanol. It is a synthetic compound extensively employed in laboratory experiments to measure the activity of AChE, a vital enzyme responsible for the breakdown of the neurotransmitter acetylcholine (ACh) in the central and peripheral nervous systems. Additionally, it enables the evaluation of drug effects on AChE activity and facilitates investigations into the impact of toxins on the nervous system. Acetylthiocholine iodide functions as an inhibitor of AChE. By binding to the enzyme′s active site, it prevents AChE from catalyzing the breakdown of ACh. Consequently, ACh accumulates in the synaptic cleft, leading to increased neuron excitability. This inhibition of AChE by ATCI ultimately results in a higher ACh concentration within the synaptic cleft, yielding a range of physiological effects. These effects encompass heightened muscle contraction, increased heart rate and blood pressure, elevated salivation, intensified bronchial secretions, and augmented gastrointestinal activity[1].

VerwendenAcetylthiocholine iodide has been used as a substrate in the preparation of acetylcholine esterase (AChE) assay working solution for AChE activity assay. It has also been used as a component in phosphate buffer (PB) for cholinesterase assay.

Vor- und nachgelagerte Produkte

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国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Suzhou Victorypharm Co.,Ltd.+86-13916956214 · [email protected]

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