HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Chlor-4-nitrobenzol
1-CHLORO-4-NITROBENZENE · PNCB · P-CHLORONITROBENZENE · 4-NITROCHLOROBENZENE · P-NITROCHLOROBENZENE · PARA NITROCHLOROBENZENE · PARA-CHLORONITROBENZENE · 4-Nitrophenyl chloride
Identifikatoren & physikalische Daten
| CAS No. | 100-00-5 |
|---|---|
| Summenformel | C6H4ClNO2 |
| Durchschnittliche Molmasse | 157,55 g/mol |
| Monoisotopische Masse | 156,99305605 g/mol |
| SMILES | O=[N+]([O-])c1ccc(Cl)cc1 |
| InChIKey | CZGCEKJOLUNIFY-UHFFFAOYSA-N |
| PubChem CID | 7474 |
| ChEMBL | CHEMBL56970 |
| ChEBI | CHEBI:34399 |
| EC No. | 202-809-6 |
| DTXSID | DTXSID5020281 |
| Lokaler Name | 1-Chlor-4-nitrobenzol |
Chemische & physikalische Eigenschaften
| XLogP | 2,4 |
|---|---|
| Polarare Oberfläche (TPSA) | 45,8 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 10 |
| Formalladung | 0 |
| Komplexität | 126 |
| Stoffklassen | Nitrogen Compounds -> Nitros, AromaticReactive agents - 3rd degree |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| Pestizide | InsecticidesActive substance -> EU Pesticides database: Not approved |
| LogP (Verteilungskoeffizient) | log Kow = 2.392.45 |
| Geruch | Sweet odor |
| Dichte | 1.52 at 64 °F (NTP, 1992) - Denser than waterwill sink1.520Relative density (water = 1): 1.31.2979 @ 90°C1.298 g/mL at 25 °C(lit.) |
| Viscosity | 1.07X10-3 Pa-s at 356.65 deg K |
| Color/Form | Monoclinic prismsYellow crystalsYellow, crystalline solid |
| Löslichkeit | less than 0.1 mg/mL at 75 °F (NTP, 1992)Sparingly sol in cold alc and freely in boiling alcohol, ether, carbon disulfide.Soluble in organic solventsIn water, 225 mg/L at 20 °CSolubility in water: noneSlightSoluble in acetone and alcohol (Weast, 1986)Insoluble |
| Flammpunkt | 230 °F (NTP, 1992)127 °C261 °F (closed cup)261 °F (127 °C) (closed cup)127 °C c.c.>230 °F |
| Siedepunkt | 468 °F at 760 mmHg (NTP, 1992)242 °C at 760 mm Hg242 °C @760 [mm Hg]242 °C(lit.) |
| Decomposition | ...WHEN HEATED TO DECOMPOSITION IT EMITS VERYY TOXIC FUMES OF /NITROGEN OXIDES AND HYDROGEN CHLORIDE./ |
| Schmelzpunkt | 80-83 °C(lit.) |
| Dampfdichte | 5.4 (vs air) |
| Dampfdruck | 0.09 mm Hg ( 25 °C) |
| Brechungsindex | 1.5376 (estimate) |
| Aggregatzustand | Crystals or Flakes |
| Farbe | Yellow |
| Spezifische Wärmekapazität | Cp(crystal): 1.59 J/(g·K), at 25℃ |
| Merck | 14,2151 |
| BRN | 508691 |
| Henry-Konstante | 4.90 x 10-6 atmm3/mol at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999) |
| Stabilität | Stable. Combustible. Incompatible with strong oxidizing agents, hydroxides. Reacts violently with sodium methoxide in methanol. |
| InChI | 1S/C6H4ClNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H |
| InChIKey | CZGCEKJOLUNIFY-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccc(Cl)cc1 |
| CAS Datenbank | 100-00-5(CAS DataBase Reference) |
| NIST chemische Informationen | Benzene, 1-chloro-4-nitro-(100-00-5) |
| EPA chemische Informationen | p-Chloronitrobenzene (100-00-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]P203, P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P318, P319, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] |
|---|---|
| Regulatorische Informationen | Chemical: Benzene, 1-chloro-4-nitro-Hazard Traits - Carcinogenicity2002/2076Status: Cease Manufacture Update: 16-07-2015 https://echa.europa.eu/registration-dossier/-/registered-dossier/19271-Chloro-4-nitrobenzene: HSNO Approval: HSR003035 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| Weitere Sicherheitsinformationen | IMAP assessments - Benzene, 1-chloro-4-nitro-: Human health tier II assessment |
| DOT-Kennzeichnung | Poison |
| Brandgefahren | This compound is combustible. (NTP, 1992)Combustible. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air. |
| Brandpotenzial | FIRE HAZARD SLIGHT WHEN EXPOSED TO HEAT OR FLAME. |
| Gesundheitsgefahren | Excerpt from NIOSH Pocket Guide for p-Nitrochlorobenzene: |
| Gefahrenübersicht | Listed in a table of Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicityliver injury seen in subchronic animal studies[ACGIH] Can induce methemoglobinemiaMay cause skin sensitization[ICSC] |
| DOT-Nummer und Handbuch | 1578 152 |
| Reaktive Gruppe | Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic |
| UN-Einstufung | UN Hazard Class: 6.1UN Pack Group: II |
| Special Reports | DHHS/NTPNTP Technical Report on Toxicity Studies of 2-Chloronitrobenzene and 4-Chloronitrobenzene Administered by Inhalation to F344/N Rats and B6C3F1 Mice. Toxicity Rpt Series No.33 NIH Publication No. 93-3382 (1993)USEPA: High production volume (HPV) Chemical Challenge Program TEST PLAN for the Chloronitrobenzene category. Available from the database query page at http://cfpub.epa.gov/hpv-s/ as of June 26, 2007European Chemicals BureauIUCLID Dataset, 1-chloro-4-nitrobenzene (CAS # 100-00-5) (2000 CD-ROM edition). Available from the Database Query page at: http://ecb.jrc.it/esis/esis.php as of June 26, 2007. Revised version available as an attachment in the Organisation for Economic Cooperation and DevelopmentScreening Information Data Set for 1-Chloro-4-nitrobenzene, CAS # 100-00-5 (2002). Available from the Database Query page at: http://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html as of June 26, 2007.Organisation for Economic Cooperation and Development |
| TSCA-Anforderungen | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. p-Nitrochlorobenzene is included on this list. |
| Brandbekämpfung | Fires involving this compound can be controlled with a carbon dioxide, dry chemical or Halon extinguisher. A water spray may also be used. (NTP, 1992)Use water spray, dry powder, foam, carbon dioxide. Combat fire from a sheltered position. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.Rinse with plenty of water (remove contact lenses if easily possible).Rinse mouth. Refer for medical attention . |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.(General first aid procedures) |
| Sichere Lagerung | Separated from combustible substances, reducing agents and food and feedstuffs. Ventilation along the floor. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. |
| Expositionsschutz und Persönliche Schutzausrüstung | Biological Exposure Indices (BEI) [ACGIH] - Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
| Brandbekämpfungsverfahren | Water may cause foaming or frothing. Use water spray, dry chemical, foam, or carbon dioxide. /chloronitrobenzens/CARBON DIOXIDE, DRY CHEMICALThis chemical is a combustible solid. It does not really ignite. Use dry chemical, carbon dioxide, water spray, or alcohol or polymer foam extinguishers. Poisonous gases are produced in fire. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. Containers may explode in fire. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156.If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. /Chloronitrobenzenes, para, solid/ |
| Lagerbedingungen | Store in cool, dry, well-ventilated location. Separate from alkalies and oxidizing materials. /Chloronitrobenzenes/Store in a refrigerator and protect from light, oxidizers, reducing agents, alkalis, and sodium methoxide. Sources of ignition such as smoking and open flames are prohibited where this chemical is handled, used, or stored. Metal containers involving the transfer of 5 gallons or more of this chemical should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment and fittings. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA standard 1910.1045.... materials which are toxic as stored or which can decomp into toxic components ... should be stored in cool, well-ventilated place, out of ... direct rays of ... sun, away from ... high fire hazard ... should be periodically inspected ... incompatible materials should be isolated. |
| Reinigungsverfahren | Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Dampen spilled material with alcohol to avoid dust, then transfer material to a suitable container. Use HEPA vacuum or wet method to reduce dist during clean-up. Do not dry sweep. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.1. Ventilate area of spill. 2. For small quantities, sweep onto paper or other suitable material, place in an appropriate container and burn in a safe place (such as a fume hood). Large quantities may be reclaimedHowever, if this is not practical, dissolve in a flammable solvent (such as alc) and atomize in a suitable combustion chamber equipped with an appropriated effluent gas cleaning device.Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. /Chloronitrobenzenes, para, solid/Environmental considerations-water spill: Use natural barriers or oil spill control booms to limit spill travel. Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. Remove trapped material with suction hoses. /Chloronitrobenzenes, para, solid/Environmental considerations-air spill: Apply water spray or mist to knock down vapors. /Chloronitrobenzenes, para, solid/ |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.1. By making packages of p-nitrochlorobenzene in paper or other flammable material and burning in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. 2. By dissolving p-nitrochlorobenzene in a flammable solvent and atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. |
| Verschüttetes entsorgen | Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protectionequipment should be worn even when contact lenses are in place.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimizepersonnel exposure to airborne contaminants.Totally enclosed systems are preferred. Where appropriate, air analysis can be helpful ... a high std of personal hygiene ... /such as/ warm shower with plenty of soap and water vigorously applied at end of shift, will minimize chronic exposure. /nitro-cmpd, aromatic/The worker should immediately wash the skin when it becomes contaminated.For more Preventive Measures (Complete) data for 1-CHLORO-4-NITROBENZENE (9 total), please visit the HSDB record page. |
| Cancer Sites | [in animals: vascular & liver tumors] |
| Wechselwirkungen | ... Ingestion of ethyl alcohol ...aggravates the intoxication. /Nitrochlorobenzene/ |
| Zielorgane | Blood, liver, kidneys, cardiovascular system, spleen, bone marrow, reproductive system |
| Ökotoxizitätswerte | LC50 Leuciscus idus /(Ide)/ 2.0 mg/L for 48 hr /Conditions of bioassay not specified in source examined/LC50 Leuciscus idus melanotus /golden ide/ 16 mg/L for 96 hr/ Static bioassayLC50 Oryzias latipes /(Japanese medaka)/ 14 mg/L for 48 hr /Semistatic bioassayLC50 Cyrinus carpio (carp) 35 mg/L for 48 hr /Conditions of bioassay not specified in source examined/For more Ecotoxicity Values (Complete) data for 1-CHLORO-4-NITROBENZENE (15 total), please visit the HSDB record page. |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 310(SRC), determined from a structure estimation method(2), indicates that 1-chloro-4-nitrobenzene is expected to have moderate mobility in soil(SRC). Volatilization of 1-chloro-4-nitrobenzene from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 4.9X10-6 atm-cu m/mole(3). 1-Chloro-4-nitrobenzene is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.022 mm Hg at 25 °C(4). Screening tests using activated sludge(5), suggest biodegradation of 1-chloro-4-nitrobenzene proceeds slowly in soil.AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 310(SRC), determined from a structure estimation method(2), indicates that 1-chloro-4-nitrobenzene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 4.9X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 152 hours and 73 days, respectively(SRC). According to a classification scheme(5), BCF values of 5.8-20.9 measured in fish(6), suggest bioconcentration in aquatic organisms is low(SRC). Screening tests using activated sludge(6), suggest biodegradation of 1-chloro-4-nitrobenzene proceeds slowly in water. Weak absorption of UV light greater than 290 nm by 1-chloro-4-nitrobenzene in methanol indicates potential for photolysis of 1-chloro-4-nitrobenzene in sunlit surface water(7).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-chloro-4-nitrobenzene , which has a vapor pressure of 0.022 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-chloro-4-nitrobenzene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 94 days(SRC), calculated from its rate constant of 1.7X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Weak absorption of UV light greater than 290 nm by 1-chloro-4-nitrobenzene in methanol indicates potential for photolysis by sunlight of 1-chloro-4-nitrobenzene in air(4). |
| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Expositionspfade | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| Toxizitätsübersicht | 1-Chloro-4-nitrobenzene is rapidly absorbed via skin, gastrointestinal tract or respiratory tract and distributed in the tissue predominantly in fat, blood cells, skeletal muscles, liver and kidney. Most of the substance was excreted with the urine followed by excretion with feces. 1-Chloro-4-nitrobenzene undergoes three major types of transformation in vivo in mammals: nitro-group reduction, displacement of the chloride in glutathione conjugation, and ring hydroxylation. From accidental exposure of workers to 1-chloro-4-nitrophenol, large amounts of 2-chloro-5- nitrophenol, N-acetyl-S-(4-nitrophenyl)-L-cysteine, 4-chloroaniline and 4-chloroformanilide were identified. The oral LD50 for 1-chloro-4-nitrobenzene in male rats is 294 or 694 mg/kg bw and in female rats 565 or 664 mg/kg bw. Cyanotic appearance was the predominant symptom. The ... LC50 level could not be reached up to 16100 mg/cu m during a 4-hrs exposure against vapor and microcrystalline particles. The LD50 (dermal) for male rats is 750 mg/kg bw and for female rats 1722 mg/kg bwthe LD50 for male rabbits is 3550 mg/kg bw and for female rabbits 2510 mg/kg bw after acute dermal application. Cyanotic appearance was the predominant symptom. For the evaluation of acute toxicity it has to be taken into account that 1-chloro-4-nitrobenzene is a methemoglobin forming chemical. Experience with human exposure: all available reports relate to mixed exposure, frequently in combination with 1-chloro-2-nitrobenzene and/or nitrobenzene. A critical aspect in this context is that 1-chloro-4-nitrobenzene is rapidly absorbed via skin and the respiratory tract. The signs of acute intoxication include methaemoglobinaemia, vomiting, headache and in severe cases collapse. The available study-reports on skin irritation have deficiencies with regard to the description of the results, nevertheless, 1-chloro-4-nitrobenzene is judged to be slightly irritating to the skin (intact or scarificed) of rabbits ... Due to the limited and poor quality information available regarding skin sensitization it cannot be concluded whether or not the chemical has a sensitizing activity. The repeated dose toxicity via inhalation has been examined in rats for a period of 4 weeks and 13 weeks. In both studies, NOAECs were not achieved, the LOAECs were 5 mg/cu m (4 week-study) and 1.5 ppm (9.81 mg/vu m, 13 week-study), respectively, based on methemoglobinemia (3 % and 4 %, respectively) as the most sensitive effect. ... The repeated dose toxicity via inhalation for a period of 13 weeks in mice revealed a NOAEC for histopathologic injury of 6 ppm (39.24 mg/cu m). As target organs liver, kidney (rat only), spleen and blood were identified in both species. Similarly, repeated dose toxicity by oral administration in rats ... revealed changes predominantly consistent with methemoglobinemia. ... 1-Chloro-4-nitrobenzene induced reverse mutations in bacteria. It was not mutagenic in mammalian cells in vitro (HPRT test) and in insects in vivo. A mouse lymphoma assay was positive. In vitro it induced chromosomal aberrations and sister chromatid exchanges at high dosesno UDS in rat hepatocytes was reported. The chemical induced micronuclei in mouse bone marrow in vivo at a toxic dose. In rat bone marrow it did not induce chromosomal aberrations in vivo. An in vivo SCE test was weakly positive in bone marrow cells of Chinese hamsters. DNA strand breaks were observed in liver, kidney and brain of mice. 1-Chloro-4-nitrobenzene is consequently capable of expressing mutagenic activity in vivo with low potency. A combined chronic toxicity/carcinogenicity study ... with 1-chloro-4-nitrobenzene in rats produced an increased incidence in interstitial cell tumours of the testes which were within the range of the historical control data and evaluated as not compound related. ... In another rat study ... reported in brief, no tumors were found. In the available study with mice ... reported in brief, vascular tumors (localization not specified) were found. ... Overall, taking into consideration the results of the genotoxicity tests and the limitations in the available long term studies, a carcinogenic potential cannot be ruled out. Toxicity to reproduction of 1-chloro-4-nitrobenzene has been examined in rats and mice by oral administration. In a two generation study with rats ... no impairment of fertility was observed up to 5 mg/kg bw (high dose group), nevertheless, at this dose histopathological effects in testes were observed. But the evaluation of the effect on the male reproductive tract is limited because the testes in the low and mid dose group were not examined histopathologically. Therefore a NOAEL (male reproductive organ toxicity) was not established. ... In mice a study was performed using the NTP continuous breeding protocol. The NOAEL (fertility) is 125 mg/kg bw/day, the LOAEL (offspring general toxicity) is 62.5 mg/kg bw/day. The NOAEL (adult general toxicity) is 125 mg/kg bw/day, but full evaluation is not possible because evaluation of the animals of the two lower groups were very limited. Two subchronic inhalation studies with rats and mice with histopathologic evaluations on reproductive organs are available. There was evidence of decreased spermatogenesis (24 ppm) and decrease in average estrous cycle length in rats exposed to 1-chloro-4-nitrobenzene (6 ppm and above). In female mice an increase in estrous cycle length was noted at the highest exposure group (24 ppm). Developmental toxicity of 1-chloro-4-nitrobenzene has been examined in rats and rabbits by oral administration ... a NOAEL for maternal toxicity was not achieved, the LOAEL(maternal toxicity) is 5 mg/kg bw/daythe NOAEL (developmental toxicity) is 15 mg/kg bw/day. The study with rabbits suffered from methodology deficiencies. Due to high mortality rate at the highest dose level, only two doses could be evaluated: the LOAEL (maternal toxicity) is 5 mg/kg bw/day and the LOAEL (developmental toxicity) is 5 mg/kg bw/day. Thus, in both species developmental toxicity occurred in the presence of maternal toxicity. There are indications of immunotoxic potency following single and repeated applications of 1-chloro-4- nitrobenzene. Concerning the toxicity of 1-chloro-4-nitrobenzene towards aquatic species reliable experimental results of tests with fish, daphnia, and algae are available. The acute toxicity determined for fish (Brachydanio rerio) was of 14.36 mg/L (96 hr LC50) and 2 mg/L (48 hr) for Leuciscus idus and for daphnia (Daphnia magna) of 2.7 mg/L (48 hr-EC50). In the growth rate tests with algae (Scenedesmus subspicatus) the values 4.9 mg/L (48 hr-ErC10) and 16 mg/L (48 hr- ErC50) were achieved while for Chlorella pyrenoidosa an effect value of 4.9 mg/L (96 hr-EC50) was found. The prolonged toxicity to fish (Brachydanio rerio) for the endpoint sub-lethal effects (feeding, malposition) was evaluated through a 14 days test and a NOEC value of 1.53 mg/l was determined. Two chronic tests with Daphnia (Daphnia magna) are available that were performed with analytical monitoring of the test substance concentration. In one test a 21 d-EC10 of 0.103 mg/L (effective concentration) was observed for the endpoint reproduction rate. The second test resulted in a 21d-NOEC of 0.19 mg/L (effective concentration) for the same endpoint. Calculating the geometric mean of these two values gives a NOEC of 0.14 mg/Ll. A PNECaqua = 2.8 g/L is derived from this value, using an assessment factor of 50. |
| Ökotoxizitätsauszüge | /AQUATIC SPECIES/ Twenty-one-day Daphnia reproduction tests were conducted in line with the provisional procedure proposed by the Federal Environmental Agency (Umweltbundesamt, FRG), as of Jan 1, 1984. Groups of 20, 24-hr old Daphnia magna Straus were exposed to 0.08 to 20 mg/L 1-chloro-4-nitrobenzene in semi-static test vessels. Parent animals in the test and control vessels had to be pipetted 3 times/wk in freshly prepared test and control media at the corresponding concn level. The no observed effect concn (NOEC) was determined from the parameters of mortality of the parent animals, reproduction rate and appearance of the first offspring during the test period. In preliminary acute Daphnia tests, the 24 hr EC50 was 15 mg/l for 1-chloro-4-nitrobenzene, the EC0 was 3.3 mg/L. The nominal 21 day no observed effect concn was 0.32 mg/L, with the most sensitive parameter being the reproductive rate. |
| Signs and Symptoms | Blue lips, fingernails and skin. Dizziness. Headache. Nausea. Vomiting. Weakness.MAY BE ABSORBED! See Inhalation.Redness.Anoxiaunpleasant tasteanemiamethemoglobinemiaIn Animals: hematuria (blood in the urine)spleen, kidney, bone marrow changesreproductive effects[potential occupational carcinogen] |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=100-00-5] |
| Effluent Concentrations | o-, m- and p-Chloronitrobenzene were identified in m-chloronitrobenzene waste water at a concentration of 1.5-1.8 g/L(1). |
| Luftstandards | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. p-Chloronitrobenzene is produced, as an intermediate or a final product, by process units covered under this subpart. |
| Wassergefährdungsklasse (WGK) | 2 |
| Sofort lebensgefährliche Konzentration | 100 mg/m3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 1578 6.1/PG 2 |
| Zollcode | 29049085 |
| RTECS-Nr. | CZ1050000 |
| R-Sätze (R) | 23/24/25-40-48/20/21/22-51/53-68 |
| Toxizität | LD50 (skin) for rats 16 gm/kg (quoted, RTECS, 1985). |
| Gefahrensymbole | T,N |
| hazard_note | Very Toxic |
| Sicherheitshinweise (S) | 28-36/37-45-61-28A |
| Gefahrenklasse | 6.1Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralAquatic Chronic 2Carc. 2Muta. 2STOT RE 2 |
| Verpackungsgruppe | II |
| Lagerklasse | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| Gefahrstoffdaten | 100-00-5(Hazardous Substances Data) |
| Selbstentzündungstemperatur | 500 °F |
Anwendungen & Verwendung
Verwenden
4-Nitrochlorobenzene is an important intermediate in the manufacture of azo dyes and sulfide dyes, the drugs finasteride and paracetamol, the pesticide herbicide, etc. It is also the raw material of rubber antioxidant 4010.