2-(Diethylamino)ethanol

Nitrogen Compounds -> Ethanolamines

Flammable agents - 2nd degree

Industrial compound

NAUSEATING ODOR

Nauseating, ammonia-like odor.

0.8921 at 77 °F (USCG, 1999) - Less dense than water; will float

0.8921 @ 20 °C/4 °C

Relative density (water = 1): 0.88

0.89

0.8851 @ 20°C

0.89

COLORLESS LIQUID

Colorless liquid.

Very soluble (NTP, 1992)

SOL IN ALL PROPORTIONS IN WATER; SOL IN ALC, ETHER, ACETONE, BENZENE, PETROLEUM ETHER

1000000 mg/L @ 25 °C (exp)

Solubility in water: miscible

Miscible

140 °F (NTP, 1992)

49 °C

140 °F (OPEN CUP)

125 °F (closed cup)

52 °C c.c.

140 °F

325 °F at 760 mmHg (NTP, 1992)

163 °C @ 760 MM HG

163.00 °C. @ 760.00 mm Hg

163 °C

325 °F

162 °C @760 [mm Hg]

Danger

H226: Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Danger

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P234, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P362+P364, P363, P370+P378, P390, P403+P233, P403+P235, P405, P406, and P501 (click each P-code to see the statement)

Chemical: Ethanol, 2-(diethylamino)-

Ethanol, 2-(diethylamino)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2-(diethylamino)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 10-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/2134

2-Diethylaminoethanol: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Special Hazards of Combustion Products: Toxic and irritating gases may be generated.

· Flammable/combustible material.

Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 52 °C explosive vapour/air mixtures may be formed.

INHALATION: Irritation of mucous membranes. EYES: Corrosive, causes intense pain. SKIN: Severe irritation. May cause allergic skin reaction. INGESTION: Gastrointestinal irritation. (USCG, 1999)

· May cause toxic effects if inhaled or ingested.

Corrosive to skin; [Quick CPC] Possible cause of asthma; [Reference #1] Causes upper and lower respiratory tract irritation; Rats show signs of upper respiratory irritation with exposures above 120 mg/m3; [NIOSH Criteria Document] May cause allergic contact dermatitis; [CAMEO] Corrosive to the eyes; [ICSC]

2686 132

2686 132

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

(General first aid procedures)

· Wear positive pressure self-contained breathing apparatus (SCBA).

2.0 [ppm] (Ceiling = 5 ppm)[German Research Foundation (DFG)]

Wear goggles, self-contained breathing apparatus and rubber overclothing (including gloves).

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical.

Overspread sufficient sodium bisulfate and sprinkle water. Drain into the sewer with abundant water.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. Diethylaminoethanol should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion. Sewers designed to preclude the formation of explosive concentrations of diethylaminoethanol vapors are permitted.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Drain into the sewer with abundant water. (a) Dissolve in a combustible solvent such as alcohols, etc. Burn in an open furnace by igniting from a safe distance with the utmost care or sprinkle into the fire chamber of the furnace with afterburner and scrubber. (b) Pour into sodium bisulfate in a large evaporating dish. Sprinkle water and neutralize. Drain into the sewer with sufficient water.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet or significantly contaminated should be removed or replaced.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Build dikes to contain flow as necessary. Use water spray to knock-down vapors.

For more Preventive Measures (Complete) data for DIETHYLAMINOETHANOL (6 total), please visit the HSDB record page.

LC50 Pimephales promelas (fathead minnow) 1780 mg/l/96 hr (95% confidence limit 1660-1920 mg/l), flow-through bioassay with measured concentrations, 24.9 °C, dissolved oxygen 6.5 mg/l, hardness 40.8 mg/l calcium carbonate, alkalinity 40.9 mg/l calcium carbonate, and pH 7.70

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Cough. Nausea. Sore throat. Vomiting. Dizziness.

MAY BE ABSORBED! Redness. Pain.

Redness. Pain. Blurred vision.

Abdominal pain. Diarrhoea.

irritation eyes, skin, respiratory system; nausea, vomiting

Employees should be screened for history of certain medical conditions which might place the employee at increased risk from diethylaminoethanol exposure. /These are/ chronic respiratory disease ... skin disease ... /and/ eye disease. ... Any employee developing the above-listed conditions should be referred for further medical examination.

/Diethylaminoethanol/ can also produce nausea and vomiting.

An attempt by a laboratory worker to remove animals from an inhalation chamber containing approx 100 ppm resulted in nausea and vomiting within 5 min after a fleeting exposure; no irritation of the eyes or throat was noted during this brief exposure. Other persons in the same room also complained of a nauseating odor but showed no ill effects.

Environmental samples were analyzed for diethylaminoethanol at the Johnson Museum, Cornell University, Ithaca, New York in January 1983. The survey was requested by the 40 employees because of eye irritation and dermatitis. Diethylaminoethanol was used to humidify the air in the museum. Air samples and bulk samples were analyzed for diethylaminoethanol. Medical interviews were conducted. Of the 14 samples taken, only 2 had detectable amounts of diethylaminoethanol. The two concentrations were 0.05 and 0.04 mg/cu m. This was below the OSHA standard of 50 mg/cu m. The two bulk samples contained about 30 mg per square meter of exposed area. A total of 46% of the employees complained of eye irritation, 37% complained of skin irritation, and 17% complained of headache, nose and throat irritation, or dizziness. Six females reported gynecological problems. /It was/ concluded that contact with surfaces coated with condensed diethylaminoethanol may be responsible for some of the irritant effects. It is recommended that diethylaminoethanol be wiped from surfaces, or the use of diethylaminoethanol be discontinued.

In response to a request from a management representative an evaluation was made of an outbreak of illness at a /electronics manufacturing plant/ located in Cincinnati, Ohio. The company manufactured electrical circuit boards and electrical equipment for the commercial and defense industries. In September of 1988 two boilers were prepared for operation by adding corrosion inhibitinq chemicals, diethylaminoethanol and cyclohexylamine. Steam produced by the boilers was used for humidity in the work area. Symptoms consistent with acute toxic effects of diethylaminoethanol and cyclohexylamine were noted in 65 of the employees. These included nausea, dizziness, vomiting, and eye, nose, and throat irritation. A significantly higher risk of having several symptoms was noted among the employees in the areas humidified with boiler steam than among employees in the nonboiler steam humidified areas. Employee exposures to metals from solder fumes and methyl-ethyl-ketone were all below established-limits. There was friable asbestos insulation exposed on one boiler. /It was/ concluded that the exposures to the two corrosion inhibiting chemica1s were responsible for the workers' symptoms.

On March 23, 1981, the National Institute for Occupational Safety and Health (NIOSH) received a request for a Health Hazard Evaluation from Boehring Ingelheim, Ltd, Ridgefield, Connecticut. The request stated that approximately 15 employees in the office support area of a production building had been experiencing rashes since the beginning of March 1981. Environmental samplinq did not reveal any diethylaminoethanol in air samples. However, results of sampling suggested the presence of a conjugated amine which possesses acidic properties. The specific agent could not be identified. Skin examinations revealed an irritant-type rash on the exposed areas of the face neck and hands. The distribution of the rash was consistent with and suggestive of a phototoxic skin reaction. Both the environmental and medical evaluations indicated the source of the dermatitis to be the air-handling system. However, no specific etiologic agent has been identified. The information in the body of the fu11 report suggests that a condensation or reaction product of diethylaminoethanol was likely responsible for the reported symptoms.

... EYE INJURY FROM THE FLUID /IS/ VERY SEVERE IN RABBIT FROM 0.005 ML UNDILUTED, SEVERE FROM 15% OR MORE IN GLYCOL & NOT SEVERE FROM 5% IN GLYCOL.

... REPEATED, DAILY INHALATION EXPOSURES OF RATS @ 500 PPM (+ OR -10%) REVEALED MARKED EYE & NASAL IRRITATION ON THE FIRST EXPOSURE DAY. MILD TREMORS OF THE HEAD & FORELEGS CONTINUED THROUGHOUT THE 5-DAY EXPOSURE PERIOD. CORNEAL OPACITY WAS OBSERVABLE IN A NUMBER OF THE RATS BY THE THIRD DAY, & BY THE FIFTH EXPOSURE 4 OF 20 ANIMALS HAD DIED. ALL ANIMALS LOST 40 TO 80 G. AUTOPSY SHOWED ACUTE PURULENT BRONCHITIS, AND BRONCHOPNEUMONIA BUT NO OTHER ORGAN INVOLVEMENT.

... EXPOSURES @ 200 PPM (+ OR - 5%) RESULTED IN WEIGHT LOSS & EVENTUAL DEATH OF 7 OF THE 50 RATS EXPOSED BY ONE MONTH. BRONCHOPNEUMONIA WAS APPARENT CAUSE OF DEATH. AT THE END OF THREE MONTHS, APPARENT ADAPTATION OCCURRED, AS NO CLINICAL VARIABLES THAT WERE MEASURED DIFFERED FROM THE CONTROLS; SIMILAR FINDINGS WERE MADE AT THE END OF SIX MONTHS. HISTOPATHOLOGIC EXAMINATION REVEALED THAT CONTROL AND EXPOSED ANIMAL TISSUES WERE NOT SIGNIFICANTLY DIFFERENT.

DIETHYLAMINOETHANOL BLOCKED IMPULSE CONDUCTION IN FROG SCIATIC NERVES, BUT HAD NO LOCAL ANESTHETIC EFFECT ON RABBIT CORNEA.

For more Non-Human Toxicity Excerpts (Complete) data for DIETHYLAMINOETHANOL (13 total), please visit the HSDB record page.

In persons with impaired pulmonary function, especially those with obstructive airway diseases, the breathing of diethylaminoethanol might cause exacerbation of symptoms due to its irritant properties. ... Persons with pre-existing skin disorders may be more susceptible to the effects of this agent. ... Those with pre-existing eye problems may be at increased risk from exposure.

LD50 Rabbit skin 1,260 mg/kg

LD50 Guinea pig skin 1,000 mg/kg

LD50 Rat oral 1,300 mg/kg

LD50 Rat ip 1,220 mg/kg

For more Non-Human Toxicity Values (Complete) data for DIETHYLAMINOETHANOL (7 total), please visit the HSDB record page.

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

ORALLY ADMIN TO RATS, WAS MAINLY EXCRETED VIA KIDNEYS. ELIMINATED WITHIN FIRST 24 HR. AFTER 48 HR EXCRETED INDEPENDENTLY OF DOSE. AFTER 40 DAYS STILL BEING ELIMINATED. UP TO 60% ACCUMULATED IN LIVER. CNS & SPINAL CORD SHOWED HIGHEST CONCN AFTER 7 DAYS.

The absorption of 2-diethylaminoethanol (administered orally as 2-diethylaminoethanol acid malate or 'Cerebrol') in healthy adult rats is very rapid, reaching a peak plasma level in 30 min. The biological half-life is 3.5 hr with 39% of the excreted product appearing in the urine after 48 hr.

Used as an isocyanate curing agent; [Sullivan, Table 34-2, p. 471] Used as a chemical intermediate for pharmaceuticals, cosmetics, flocculants, emulsifiers, surface coatings, and other organic chemicals (in the chemical, agricultural, plastics, paper, and leather industries); [HSDB]

Pulp and Paper Processing [Category: Industry]

MFR OF EMULSIFYING AGENTS AND SPECIAL SOAPS

CHEM INT FOR PETROLEUM & GAS PROCESSING CHEMS, COSMETICS, SURFACE COATINGS, TEXTILES & FIBERS, PROCAINE, CHLOROQUINE

WATER-SOL SALTS; FATTY ACID DERIVATIVES; TEXTILES SOFTNERS; PHARMACEUTICALS; ANTIRUST COMPOSITIONS; EMULSIFYING AGENTS IN ACID MEDIA; DERIVATIVES CONTAINING TERTIARY AMINE GROUPS; CURING AGENT FOR RESINS

Intermediate in production of pharmaceuticals, crop protection agents, and flocculants. Preparation of chemicals for the paper and leather industries; production of plastics.

... BY ACTION OF ETHYLENE CHLOROHYDRIN ON DIETHYLAMINE

... BY ACTION OF ETHYLENE OXIDE ON DIETHYLAMINE

National Starch and Chemical Liquid Grade

GRADE: TECHNICAL

Specification: 99% min purity

Utilities

Ethanol, 2-(diethylamino)-: ACTIVE