| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 98.3% (5522 of 5617) of all reports.Not ClassifiedReported as not meeting GHS hazard criteria by 5522 of 5617 companies (only 1.7% companies provided GHS information). For more detailed information, please visit ECHA C&L website.Aggregated GHS information provided per 5617 reports by companies from 16 notifications to the ECHA C&L Inventory.Reported as not meeting GHS hazard criteria per 5522 of 5617 reports by companies.There are 13 notifications provided by 95 of 5617 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
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| Regulatorische Informationen | Chemical: 1,2,3-PropanetriolCommission Regulation (EU) No 231/2012 (amended)Regulation (EC) No 1333/2008 (amended)1,2,3-Propanetriol is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetriol are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 18-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14481Propanetriol: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
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| Weitere Sicherheitsinformationen | IMAP assessments - 1,2,3-Propanetriol: Human health tier I assessmentIMAP assessments - 1,2,3-Propanetriol: Environment tier I assessment |
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| Brandgefahren | This chemical is combustible. (NTP, 1992)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
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| Gesundheitsgefahren | No hazard (USCG, 1999) |
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| Gefahrenübersicht | No listed effects of short-term or long-term exposure[ICSC] |
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| FDA-Anforderungen | Substances migrating to food from paper and paperboard products used in food packaging that are generally recognized as safe for their intended use, within the meaning of section 409 of the Act: Glycerin is included on this list.Glycerin used as a multiple purpose GRAS food substance in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.Glycerin used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. |
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| Reaktive Gruppe | Alcohols and Polyols |
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| EPA Safer Chemical | Chemical: GlycerolGreen circle - The chemical has been verified to be of low concern based on experimental and modeled data. |
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| FIFRA-Anforderungen | Residues resulting from the use of the following substances as either an inert or an active ingredient in a pesticide chemical formulation, including antimicrobial pesticide chemicals, are exempted from the requirement of a tolerance under FFDCA section 408, if such use is in accordance with good agricultural or manufacturing practices. Glycerin is included on this list.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Glycerol is found on List D. Case No: 4044Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.Active ingredient (AI): GlycerolAI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled." |
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| OSHA Standards | Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 15 mg/cu m. /Mist, total dust/Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 5 mg/cu m. /Mist, respirable fraction/Vacated 1989 OSHA PEL TWA 10 mg/cu m is still enforced in some states. /Mist, total/Vacated 1989 OSHA PEL TWA 5 mg/cu m is still enforced in some states. /Mist, resp/ |
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| Reactivity Profile | GLYCERINE is incompatible with strong oxidizers. It is also incompatible with hydrogen peroxide, potassium permanganate, nitric acid + sulfuric acid, perchloric acid + lead oxide, acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, CrO3, F2 + PbO, KMnO4, K2O2, AgClO4 and NaH. A mixture with chlorine explodes if heated to 158-176 °F. It reacts with acetic acid, potassium peroxide, sodium peroxide, hydrochloric acid, (HClO4 + PbO) and Na2O2. Contact with potassium chlorate may be explosive. It also reacts with ethylene oxide, perchloric acid, nitric acid + hydrofluoric acid and phosphorus triiodide. (NTP, 1992) |
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| Luftstandards | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Glycerol is produced, as an intermediate or a final product, by process units covered under this subpart. |
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| Brandbekämpfung | Use water spray, alcohol-resistant foam, dry powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest.Rinse skin with plenty of water or shower. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Rinse mouth. |
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| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Water wash - If this chemical contacts the skin, wash the contaminated skin with water.Breathing: Fresh air |
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| Sichere Lagerung | Separated from strong oxidants. |
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| Expositionsschutz und Persönliche Schutzausrüstung | 200.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)] |
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| Brandbekämpfungsverfahren | Water or foam may cause frothing.Extinguishing methods: Alcohol foam.To fight fire, use alcohol foam, CO2, dry chemical.This material is combustible and may explode when exposed to strong oxidizers, flame, or extreme heat. |
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| Lagerbedingungen | Glycerol should preferably be stored at 40 - 60 °C under nitrogen blanketing. It is not corrosive and presents little risk of ignition because of its high flash point. Highly concentrated glycerol does not corrode steel, but storage tanks of carbon steel must be protected by surface coating to prevent rusting by residual moisture. Glycerol is therefore usually stored in tanks of stainless steel or aluminum.Glycerin oral solution should be stored in tight containers at a temp less than 40 °C, perferably between 15-30 °Cfreezing should be avoided. Glycerin ophthalmic soln should be protected from light and stored in tight glass or plastic containers. The ophthalmic soln should be ... discarded 6 mo after the dropper is first placed in the soln.Glycerin rectal suppositories should preferably be stored at less than 25 °C.Store container tightly closed. Store at room temperature: 15 deg - 30 °C (59 deg - 86 °F). Do not exceed 30 °C (86 deg F).For more Storage Conditions (Complete) data for GLYCERIN (7 total), please visit the HSDB record page. |
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| Reinigungsverfahren | Wear approved respiratory protection, chemically compatible gloves and protective clothing. Wipe up spillage or collect spillage using a high efficiency vacuum cleaner. Avoid breathing vapor. Place spillage in appropriately labelled container for disposal.Absorb with paper. Evaporate completely all spilt surface. Dispose by burning the paper after complete ventilation of vapor. |
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| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.Mixture with a more flammable solvent followed by incineration. |
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| Verschüttetes entsorgen | Ventilation. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
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| Preventive Measures | SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.As a general rule, when handling USP Reference Standards avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Wash thoroughly after handling./Wear/ chemically compatible gloves /and/ safety glasses or goggles. Protect exposed skin. |
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| Eye Prevention | Wear safety goggles. |
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| Wechselwirkungen | Concomitant administration of carbonic anhydrase inhibitors or topical miotics may prolong the effects of glycerin.Glycerin ...and propylene glycol ...are commonly used as humectant ingredients in manufactured cigarettes to control and maintain the moisture content of the cut tobacco filler. The potential of these added humectants to affect the toxicity of cigarette smoke was investigated in a subchronic nose-only smoke inhalation study in rats. Filtered test cigarettes were prepared from an American-style tobacco blend containing either glycerin added at 5.1% wt/wt tobacco, propylene glycol at 2.2% wt/wt tobacco, or combinations of these humectants totaling 2.3%, 3.9%, and 7.2% wt/wt tobacco. Other groups of animals were exposed similarly to the smoke of reference cigarettes without added humectants, or to filtered air (sham control). Smoke exposures were conducted for 1 hr/day, 5 days/wk for 13 wk, at target smoke particulate concentrations of 350 mg/cu m. All smoke-exposed groups had equivalent increases in blood carboxyhemoglobin, serum nicotine, and serum cotinine relative to the air controls. Smoke-associated reductions in body weights and occasional increases in heart and lung weights were generally similar among the various exposure conditions at necropsy. Increases in serum alkaline phosphatase and decreases in serum glucose and cholesterol were observed among smoke-exposed females relative to air controls. However, no significant differences in these parameters were evident between the humectant-containing and reference cigarette smoke exposure groups. Assessments of respiration conducted after 3, 6, 9, and 12 wk of smoke exposure indicated an initial smoke-related but not humectant-related decrease in respiratory rate, tidal volume, and minute volume during the first 20 min of each smoke exposure. Respiratory-tract histopathology was consistent across sexes and smoke groups, comprising (1) diffuse and focal alveolar pigmented macrophages and chronic interstitial inflammation in the lung, (2) laryngeal epithelial hyperplasia, squamous metaplasia, and scab formation, anThe use of glycerol for boar semen cryopreservation results in low fertility, possibly due to toxicity. This has led to recommend the use of solutions with less than 4% glycerol. Trehalose is a disaccharide known to stabilize proteins and biologic membranes during processes such as cryopreservation. Thus, it was decided to evaluate the cryoprotective effect of glycerol/trehalose mixtures. Effects on motility (M), viability (Vb) and acrosomal integrity (nA) were evaluated. Sperm samples were frozen in three different extenders: G4 contained 4% glycerolT1 contained 1% glycerol plus 250 mM trehalose and T0.5 was constituted by 0.5% glycerol plus 250 mM trehalose. All extenders yielded similar post-freezing/thawing motility rates. Viability was diminished in T0.5 as compared to the others. In regard to acrosome integrity, it was twice as high (P<0.05) in the trehalose enriched media as in G4, the glycerol-only extender. Thus, T1 twice as many spermatozoa were alive, motile and intact, than in either T0.5 or G4, i.e. during freeze/thawing the use of T1 resulted in twice as many fertile cells as when using the other extenders. During our study, we noted that there were wide individual variations both in sperm viability and in motility.Bovine pericardium is a widely utilized biomaterial. Usually, after harvesting, it is advantageous that the pericardium be immersed in glycerol to improve its shelf life. This can induce some degree of toxicity in the material. The studies were performed in compliance with the rules of /International Organization for Standardization/ 10993 and OECD 487, in the biological evaluation of medical devices. The material was prepared without previous washing. After sterilization by gamma radiation the pericardium was immersed in RPMI 1640 culture medium to fulfill the extraction condition. The same extract was employed in the cytotoxic and genotoxic tests. The procedures were carried out with Chinese hamster ovary cell line and to determine the cytotoxicity, a colorimetric method with the tetrazolium compound...was used. For the genotoxicity, following the in vitro micronucleus assay, the test was developed with and without metabolic activation. The Cytotoxicity Index was graphically estimated at the extract concentration of 78%. In the genotoxicity test, the average value of cell proliferation index was found to be 1.62 +/- 0.02 with ...metabolic activator and 1.91 +/- 0.01 without ...metabolic activator. Both values are similar to the negative control value in the micronucleus assay. We observed that although the pericardium preserved in glycerol shows a certain level of cytotoxicity, it does not show any genotoxicity.For more Interactions (Complete) data for GLYCERIN (7 total), please visit the HSDB record page. |
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| Zielorgane | Eyes, skin, respiratory system, kidneys |
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| Gesundheitliche Auswirkungen | Chronically high levels of glycerol are associated with Glycerol Kinase Deficiency. |
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| Ökotoxizitätswerte | Toxicity threshold (cell multiplication inhibition test) Algae (Microcystis aeruginosa) 2900 mg/lToxicity threshold (cell multiplication inhibition test) Protozoa (Entosiphon sulcatum) 3200 mg/lLC50Species: GoldfishConcentration: >5000 mg/L for 24 hr - modified ASTM D 1345Species: Daphnia magna (Water flea, age < or = 24 hr)Conditions: freshwater, static, 20-22 °CConcentration: >10000 mg/L for 24 hr /formulated product/ |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that glycerin is expected to have very high mobility in soil(SRC). Volatilization of glycerin from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.73X10-8 atm-cu m/mole(3). Glycerin is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.68X10-4 mm Hg at 25 °C(4). A 63% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that glycerin is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 1.73X10-8 atm-cu m/mole(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of -1.76(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 63% of theoretical BOD using activated sludge in the Japanese MITI test(8) suggests that biodegradation is an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), glycerin, which has a vapor pressure of 1.68X10-4 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase glycerin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 7 hours(SRC), calculated from its rate constant of 1.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase glycerin may be removed from the air by wet or dry deposition(SRC). Glycerin does not contain chromophores that absorb at wavelengths >290 nm(4), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). |
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| Expositionspfade | inhalation, skin and/or eye contact |
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| Toxizitätsübersicht | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org |
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| Plant Concentrations | Glycerin was reported present in Cork Oak, Quercus suber L., in the cork at 65,000 ppm(1). |
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| Signs and Symptoms | Dry skin.Diarrhoea.irritation eyes, skin, respiratory systemheadache, nausea, vomitingkidney injury |
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| Acute Toxicity Link | Chemical: GLYCEROL |
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| Effluent Concentrations | Glycerin was found but not quantified in the primary waste treatment effluent of the Oak Ridge treatment facility in 1974(1). It was identified in the influent to the industrial wastewater treatment plant of the Kashima petrochemical complex, Japan(2). |
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| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indices(1), the Koc of glycerin can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that glycerin is expected to have very high mobility in soil. |
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