Grundinformationen
- Standard-SMILES
CNC(C)CC1CCCCC1- InChIKey
JCRIVQIOJSSCQD-UHFFFAOYSA-N- Summenformel
- C10H21N
- Durchschnittliche Molmasse
- 155,28 g/mol
- Monoisotopische Masse
- 155,16739967
Namen und Bezeichner
- Bevorzugter Name
- Propylhexedrine
- IUPAC
- 1-cyclohexyl-N-methylpropan-2-amine
- Englischer Name
- N,alpha-dimethylcyclohexaneethylamine
- Summenformel
- C10H21N
- Molmasse
- 155.28
Namen und Synonyme
PropylhexedrineBenzedrexHydromethamphetamineDristan Inhaler101-40-61-cyclohexyl-N-methylpropan-2-aminePropilhexedrinaPropylhexadrinePropylhexedrinumDL-propylhexedrine1-Cyclohexyl-2-(methylamino)propanePropilesedrina
Weitere Namen anzeigen
Chp-depotHexahydrodesoxyephedrineCyclohexaneethanamine, N,α-dimethyl-N,alpha-dimethylcyclohexaneethylamine(2-Cyclohexyl-1-methylethyl)methylamine
Methyl-(1-methyl-2-cyclohexylethyl)amineLQU92IU8LLNSC-32410(1-cyclohexylpropan-2-yl)(methyl)amine(+-)-N,alpha-DimethylcyclohexaneethylamineNSC32410Propylhexedrine dl-Cyclohexaneethanamine, N,alpha-dimethyl-
Datenbank-Bezeichner
- CAS
101-40-6、3595-11-7- PubChem CID
- 7558
- DTXSID
DTXSID1023526- ChEMBL
CHEMBL2105275- ChEBI
CHEBI:134783- UNII
- LQU92IU8LL
- EC Number
- 202-939-3、222-741-0
- Nikkaji
- J21.261J
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,5
- Polarare Oberfläche (TPSA)
- 12 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 11
- Formalladung
- 0
- Komplexität
- 95
Experimentelle und physikochemische Eigenschaften
Physical DescriptionSolid
Kovats Retention Index
1170；1210；1185；1160；1176.2；1169
1179；1179；1161.7；1166.2；1157；1187；1193；1200
1410；1421；1431
Physikochemische Eigenschaften
- Siedepunkt
- 209.13 °C · 209.13°C (estimate)
- Dichte
- 0.8501 · 0.8501
- Brechungsindex
- 1.46 · 1.4600
- pka
- 10.78 · 10.78±0.10(Predicted)
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory InformationCyclohexaneethanamine, N,.alpha.-dimethyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Regulatorische Informationen
Regulatory InformationCyclohexaneethanamine, N,.alpha.-dimethyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Sicherheitsdaten
- hazard_class
- IRRITANT
Chemie und Industrie
Pharmakologische Informationen
Pharmacodynamics
Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).
Mechanism of Action
Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.
Cellular LocationsCytoplasm；Membrane
Verwendung und Herstellung
Use ClassificationPharmaceuticals
Anwendungen
VerwendenAdrenergic (vasoconstrictor).
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