| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 12.5% (3 of 24) of reports.DangerH315 (87.5%): Causes skin irritation [Warning Skin corrosion/irritation]P203, P260, P264, P264+P265, P273, P280, P302+P352, P305+P354+P338, P317, P318, P319, P321, P332+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 24 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| Regulatorische Informationen | Chemical: Stannane, trichlorooctyl-Stannane, trichlorooctyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Stannane, trichlorooctyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 23-07-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/13860 |
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| Weitere Sicherheitsinformationen | IMAP assessments - Stannane, trichlorooctyl-: Human health tier II assessment |
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| Gefahrenübersicht | Reacts with water forming monooctyltin oxide and hydrogen chlorideAlways produced as a mixture with dioctyltin dichloride (DOTC, CAS# 3542-36-7)[OECD SIDS] Reacts with waterCauses burnsInhalation may cause corrosive injuries to upper respiratory tract and lungs[Alfa Aesar MSDS] See Dichlorodioctylstannane. |
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| Hazard Classes and Categories | Skin Irrit. 2 (87.5%)Eye damage - category 1 |
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| Expositionsschutz und Persönliche Schutzausrüstung | 0.1 [mg/m3], as Sn[German Research Foundation (DFG)] |
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| Threshold Limit Values (TLV) | 0.1 [mg/m3], as Sn0.2 [mg/m3], as Sn |
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| Permissible Exposure Limit (PEL) | 0.1 [mg/m3], as Sn |
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| Immediately Dangerous to Life or Health (IDLH) | 25.0 [mg/m3], as Sn |
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| Gesundheitliche Auswirkungen | Breathing or swallowing, or skin contact with organotins, can interfere with the way the brain and nervous system work, causing death in severe cases. Organic tin compounds may also damage the immune and reproductive system. (L307, L308) |
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| Unerwünschte Wirkungen | Neurotoxin - Other CNS neurotoxin |
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| Expositionspfade | Oral (L308)inhalation (L308)dermal (L308) |
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| Toxizitätsübersicht | Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184) |
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| Signs and Symptoms | Inorganic or organic tin compounds placed on the skin or in the eyes can produce skin and eye irritation. (L308) |
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| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
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| Wassergefährdungsklasse (WGK) | WGK 3 |
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| TSCA-Inventar-Status | TSCA listed |
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| UN-Transportnummer | 1760 |
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| R-Sätze (R) | 34 |
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| Toxizität | LD50 orl-rat: 4600 mg/kg ARZNAD 19,934,69 |
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| Sicherheitshinweise (S) | 26-36/37/39 |
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| Gefahrenklasse | 6.1(b)Aquatic Acute 1Aquatic Chronic 1Eye Dam. 1Repr. 2Skin Irrit. 2STOT RE 2 Oral |
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| Verpackungsgruppe | III |
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| Lagerklasse | 10 - Combustible liquids |
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