Dilauroylperoxid

Fire Extinguishing Agents: Water, dry chemical, foam, or carbon dioxide (USCG, 1999)

Use water in large amounts, water spray. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

WATER, DRY CHEMICAL, FOAM, OR CARBON DIOXIDE.

Combat fires from behind barrier. Flood discharge area with water. Cool exposed containers with water.

In case of fire, water should be applied by the sprinkler system or by hose from a safe distance, preferably with a fog nozzle. Foam may be necessary instead if the peroxide is diluted in a low density flammable solvent. Portable extinguishers should not be used except for very small fires. Peroxides threatened by fire should be wetted from a safe distance for cooling. /Peroxides, Organic and Inorganic/

Store in a cool, well-ventilated storage of noncombustible construction, distant from residences. Separate from other stocks, especially vulcanizing agents, easily oxidizable organic materials, and combustible material; avoid fire and sparks. Provide large-quantity storage room with cool sprinkler system. Protect containers against physical damage. Do not open containers in storage room. Do not place in glass-stopper or screw-capped containers because of possible explosion caused by frictional handling.

STORAGE REQUIREMENTS: KEEP AS COOL AS POSSIBLE, BUT BELOW 27 °C. DO NOT ADD HOT MATERIAL.

STORAGE REQUIREMENTS: BECAUSE OF THEIR INSTABILITY, MANY PEROXIDES ARE STORED AND HANDLED IN INERT VEHICLE SUCH AS DIMETHYL PHTHALATE. /PEROXIDES, ORG/

STORAGE REQUIREMENTS: IN COMMERCIAL HANDLING, SHOCK-SENSITIVE PEROXIDES ARE DILUTED WITH SOME INACTIVE VEHICLE (EG DIMETHYL PHTHALATE). /PEROXIDES, ORGANIC/

Isolate and remove discharged material. Notify local health and pollution control agencies.

IN CASE OF SPILLS, SUPPLY OF INACTIVE ABSORBENT MATERIAL (EG VERMICULITE) SHOULD BE AVAILABLE. /PEROXIDES, ORG/

Spills should be cleaned up promptly using non-sparking tools and an inert, moist diluent such as vermiculite or sand. Sweepings may be placed in open containers or polyethylene bags and the area washed with water and detergent. Spilled, contaminated, waste or questionable peroxides should be destroyed. /Peroxides, Organic and Inorganic/

Most peroxides can be hydrolyzed by adding them slowly with stirring to about ten times their weight of cold 10% sodium hydroxide solution. The reaction may require several hours. /Peroxides, Organic and Inorganic/

Dilute and drain into the sewer with abundant water. /Hydrogen peroxide/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Evacuate danger area! Consult an expert! Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Remove all ignition sources. Do NOT absorb in saw-dust or other combustible absorbents. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Cough. Sore throat.

Redness. Pain.

Redness. Pain.

PROLONGED INHALATION OF THE VAPORS /OF ORGANIC PEROXIDES/ RESULTS IN HEADACHE AND THROAT IRRITATION AND SPLASHES IN THE EYE CAN BE DAMAGING. PROLONGED SKIN CONTACT...MAY CAUSE IRRITATION AND BLISTERING. /ORGANIC PEROXIDES/

The main toxic effect of most peroxides is irritation of skin, mucous membranes and eyes. Prolonged or intense skin contact or splashes in the eyes may cause severe injury. ... /Peroxides, Organic and Inorganic/

Lauroyl peroxide

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 36: (1985) Allyl Compounds, Aldehydes, Epoxides and Peroxides

1999

1998

ANIMAL TOXICITY STUDIES HAVE INDICATED...THAT EFFECTS OF ORGANIC PEROXIDES MAY BE CUMULATIVE. /PEROXIDES, ORG/

...HAS BEEN SHOWN TO BE NONINJURIOUS WHEN APPLIED TO RABBIT EYES IN POWDER FORM.

MALE RATS GIVEN LAUROYL PEROXIDE IN EQUIV TO 0.02 OR 0.004 LD50 & LD33 WITH FOOD FOR 4 MO. DECR HEMOGLOBIN & ERYTHROCYTES, INCR RETICULOCYTES IN PERIPHERAL BLOOD, INCR METHEMOGLOBIN FORMATION, DECR BLOOD SULFHYDRYL GROUP & BLOOD PEROXIDASE.

After a single topical application of either 10, 20, or 40 mg of lauroyl peroxide...on the dorsal mouse skin, the epidermal thickness increased markedly. No major inflammatory or vascular alterations were noted. ... Lauroyl peroxide-induced hyperplasia was characterized by a sustained production of dark basal keratinocytes, which constituted approximately 10% of the basal cell population during the first week after single topical application. Although /lauroyl peroxide/ was inactive either as an initiator or as a complete carcinogen, it was...effective... when used as a skin tumor promoter in a 2-stage carcinogenesis protocol.

For more Non-Human Toxicity Excerpts (Complete) data for DILAUROYL PEROXIDE (8 total), please visit the HSDB record page.

Evaluation: No epidemiological data relevant to the carcinogenicity of lauroyl peroxide were available. There is inadequate evidence in experimental animals for the carcinogenicity of lauroyl peroxide. Overall evaluation: Lauroyl peroxide is not classifiable as to its carciogenicity to humans (Group 3).

TREATMENT: PROMPT WASHING OF AFFECTED AREAS IS ESSENTIAL.

REMOVE CONTAMINATED CLOTHING & SHOES. FLUSH AFFECTED AREAS WITH... WATER. IF IN EYES, HOLD EYELIDS OPEN & FLUSH WITH... WATER. IF SWALLOWED & VICTIM IS CONSCIOUS, HAVE VICTIM DRINK WATER OR MILK & HAVE VICTIM INDUCE VOMITING. IF SWALLOWED & VICTIM IS UNCONSCIOUS OR HAVING CONVULSIONS, DO NOTHING EXCEPT KEEP VICTIM WARM.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool .... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Organic peroxides/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic peroxides/

Peroxides should be washed promptly from the skin to prevent irritation. In the case of eye contact, the eyes should be flushed immediately with large amounts of water, and medical attention should be obtained. ... /Peroxides, Organic and Inorganic/