N-Ethylheptadecafluoroctansulfonamid

In case of spill, avoid contact, isolate area and keep out animals and unprotected persons. Confine spills. ... To confine spill: Cover to prevent dispersal. Place damaged package in a holding container. Identify contents. /FirstLine Termite Bait Station/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Wastes resulting from the use of this product may be disposed of on site or at an approved waste disposal facility. /FirstLine Termite Bait Station/

Container Disposal: Wrap FirstLine Tennite Bait Station and put in trash. Plastic bags: Completely empty bag. Then dispose of empty bag in a sanitary landfill or by incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of smoke. /FirstLine Termite Bait Station/

Avoid contact with skin, eyes or clothing. Wash thoroughly with soap and water after handling. /FirstLine Termite Bait Station/

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

LD50; Species: Colinus virginianus (Bobwhite quail) oral 473 mg/kg

LC50; Species: Anas platyrhynchos (Mallard duck) dietary 165 ppm

LC50; Species: Colinus virginianus (Bobwhite quail) dietary 460 ppm

LD50; Species: Colinus virginianus (Bobwhite quail) oral 473 mg/kg

For more Ecotoxicity Values (Complete) data for SULFLURAMID (8 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 7.9X10+5(SRC), determined from a structure estimation method(2), indicates that sulfluramid is expected to be immobile in soil(SRC). Volatilization of sulfluramid from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.4 atm-cu m/mole(SRC), using a fragment constant estimation method(3). However, adsorption to soil is expected to attenuate volatilization(SRC). Sulfluramid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 4.28X10-7 mm Hg at 25 °C(4). As a class, perfluorinated organic compounds are resistant to microbial degradation(5). Similar to other perfluorinated sulfonamide derivatives, the potential exists for the conversion of the sulfonamide functional group to a sulfonic acid functional group via microbially-mediated hydrolysis(6).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 7.9X10+5(SRC), determined from a structure estimation method(2), indicates that sulfluramid is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 5.4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6.7 hours and 9.1 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 24 years if adsorption is considered(5). According to a classification scheme(6), an estimated BCF of 1.3X10+4(SRC), from an estimated log Kow of 6.8(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is very high(SRC). Hydrolysis is not expected to be an important environmental fate process since due to the presence of high-energy carbon-fluorine bonds(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sulfluramid, which has a vapor pressure of 4.28X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase sulfluramid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.8 days(SRC), calculated from its rate constant of 8.8X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase sulfluramid may be removed from the air by wet or dry deposition(SRC). The maximum absorption for sulfluramid is near 204 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Concentrations of sulfluramid in 10 guillemot (Uria aalge) egg samples from each location. Sulfluramid was not detected (detection limit 1.1 ng/g wet weight) in 10 guillemot egg samples collected in 2003 from Sanday, Faroe Islands(1).[Table#6720]

Sulfluramid was detected in five narwhal (Monodon monoceros) and five beluga whales (Delphinapterus leucas) sampled from the Arctic at 0.5-6.9 and 0.1-11.7 ng/g wet weight, respectively(1).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of sulfluramid can be estimated to be 7.9X10+5(SRC). According to a classification scheme(2), this estimated Koc value suggests that sulfluramid is expected to be immobile in soil(SRC).

URBAN/SUBURBAN: Sulfluramid was detected in atmospheric samples from Barsbuttel, Germany at a maximum concentration of 1.4 pg/cu m, each sample was collected over a three to four day time span and the study was run April 2007 to June 2008(1).

RURAL/REMOTE: Perfluorinated chemicals have become widespread in the artic atmosphere(1). Sulfluramid was detected in atmospheric samples collected from onboard the Polarstern on a cruise from Bremerhaven, Germany to Capetown, Africa at concentrations of <0.3 to 2.2 pg/cu m; the cruise was run from Oct 13 to Nov 17, 2005(2).

INDOOR: Sulfluramid was detected in 40 indoor air samples from Oslo, Norway households at 0.30 to 95 pg/cu m(1). Sulfluramid was detected in 52 of 59 indoor air samples collected the winter of 2002 to 2003 from homes in Ottawa, Canada at concentrations of 5.94 to 646 pg/cu m(2).

Sulfluramid was detected in five zooplankton, five clam (Mya truncata; Serripes groenlandica, five shrimp (Pandalus borealis; Hymenodora glacialis) and three Arctic cod (Boreogadus saida) samples at not detected to 0.65, 1.9 to 85.9, not detected to 44.8 and 9.6 to 144.6 ng/g, respectively(1). Sulfluramid was not detected in redfish (Sebastes mentella). Fish and shrimp samples were collected from Davis Strait, Nunavut, Canada, Oct of 2000 and 2001(1). Clams and zooplankton samples were collected from Frobisher Bay, Nunavut, Canada, May 2002(1).

As a class, perfluorinated organic compounds, such as sulfluramid, are resistant to microbial degradation(1). Similar to other perfluorinated sulfonamide derivatives, the potential exists for the conversion of the sulfonamide functional group to a sulfonic acid functional group via microbially-mediated hydrolysis(2). However, sulfonamides cannot be characterized as readily biodegradable(3).

An estimated BCF of 1.3X10+4 was calculated in fish for sulfluramid(SRC), using an estimated log Kow of 6.8(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC), provided the compound is not metabolized by the organism(SRC).

The Henry's Law constant for sulfluramid is estimated as 5.4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that sulfluramid is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 6.7 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 9.1 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 24 years when adsorption is considered(3). Sulfluramid's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Sulfluramid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 4.28X10-7 mm Hg(4).

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Sulfluramid, suspended in 1% CMC/0.1% Tween 80, was administered by gavage to three groups of 22 timed-pregnant, "litter-experienced" New Zealand White rabbits from gestation days 19-28 at levels of 0.3, 1.0 and 3.0 mg/kg/day. The F0 females were allowed to deliver naturally and rear their bunnies to PND (postnatal day) 42. Selected F1 bunnies were evaluated for developmental landmarks, and a longitudinal quantitative assessment of spermatogenesis was performed on semen from all selected F1 males. The number of bunnies stillborn or found dead on PND 0 was increased, and the viability on PND 1 was decreased in the 3.0 mg/kg/day group. In addition, postnatal viability indices in all treated groups were decreased throughout the pre-weaning period (PND 4-42). No treatment-related effects were noted on the age at which balanopreputial separation or vaginal patency occurred. The numbers of sperm/ejaculate, percentages of motile sperm, numbers of motile sperm/ejaculate and percentages of sperm with normal morphology were apparently unaffected by treatment during the 4-week longitudinal assessment of spermatogenesis. No adverse effects were apparent on mean testicular and epididymal sperm numbers, and no treatment-related histopathological findings were noted in the reproductive organs at any dose level. Although significant neonatal toxicity (mortality) was noted in all treatment groups, no treatment-related effects were noted on sexual maturation or testicular function of the F1 generation in this study.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Administration of sulfluramid (96.6% linear and 3.4% branched isomeric mixture) at dose levels of 0.8, 3.3, and 13.3 mg/kg/day from day 6 to day 15 of gestation reduced the mean maternal body weight and mean body weight gain in the 3.3 and 13.3 mg/kg/day dose groups, and reduced food consumption in the 13.3 mg/kg/day dose group. Treatment-related maternal toxicity effects, flaccid body tone and piloerection, were noted in the 13.3 mg/kg/day group. A dose-related trend of increased incomplete ossification of the 3rd and 4th sternebrae and skull, and an enlarged fontanelle were noted in the high-dose group. The reduced fetal weights and increased incidence of cleft palate (3.5% of fetuses and 16.7% of litters in this study versus 0.02% fetuses in the fetal historical control) in the 13.3 mg/kg/day are other developmental toxicity effects. The maternal toxicity NOAEL is determined to be 0.8 mg/kg/day, and the maternal toxicity LOAEL is 3.3 mg/kg/day based on reduced mean maternal body weight, mean body weight gain and the reduced food consumption. The developmental toxicity NOAEL is 3.3 mg/kg/day and the developmental toxicity LOAEL is 13.3 mg/kg/day based on reduced fetal weights and increased incidence of cleft palate, incomplete ossification of the 3rd and 4th sternebrae and skull and an enlarged fontanelle.

/GENOTOXICITY/ Under the conditions of the assay, four doses of sulfluramid (0.5, 0.75, 1.0, and 1.25 ug/mL) did not induce an appreciable increase in the net nuclear grain counts of treated rat hepatocytes. Cytotoxicity was clearly demonstrated at concentrations > or = 1.5 ug/mL. It is concluded, that sulfluramid is not genotoxic in the primary rat hepatocyte unscheduled DNA synthesis (UDS) assay.

Certain perfluoroalkyl sulfonates. (a) Chemical substances and significant new uses subject to reporting. (1) The chemical substances listed /including 1-Octanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-/ ... are subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. ... (2) The significant new uses are: ... (ii) Any manufacture or import for any use ... except as noted in paragraph (a)(3) of this section. ... (a)(3) Manufacture or import ... for the following specific uses shall not be considered as a significant new use subject to reporting under this section: (i) Use as an anti-erosion additive in fire-resistant phosphate ester aviation hydraulic fluids. (ii) Use as a component of a photoresist substance, including a photo acid generator or surfactant, or as a component of an anti-reflective coating, used in a photomicrolithography process to produce semiconductors or similar components of electronic or other miniaturized devices. (iii) Use in coating for surface tension, static discharge, and adhesion control for analog and digital imaging films, papers, and printing plates, or as a surfactant in mixtures used to process imaging films. (iv) Use as an intermediate only to produce other chemical substances to be used solely for the uses listed in paragraph (a)(3)(i), (ii), or (iii) of this section.

The Agency has considered sulfluramid in light of the standard for registration and safety factors in FIFRA and FFDCA, as amended by FQPA. EPA has found that there are not likely to be any unreasonable adverse effects to the U.S. population, including infants and children in particular, or to other non-target organisms in the environment, from the use of products containing sulfluramid when currently required label instructions are followed. Based on all available information on sulfluramid, there are no new exposure concerns for currently registered products containing sulfluramid. The Agency has determined that no additional risk assessment, data, or mitigation measures are needed prior to the completion of the phase-out of the remaining product registrations. ... The Agency has determined that the standards for Registration Review have been met and that the registrations of currently registered products containing sulfluramid can be maintained until the end of the phase-out period.

New Active Ingredients ... includes chemicals not previously registered as pesticides, as well as pesticide active ingredients initially registered after November 1, 1984 and that currently have active product registrations. By law, these pesticides must meet new safety standards, such as those described in the Food Quality Protection Act of 1996 and, if new safety standards are met, will be reviewed again on a 15-year cycle. Sulfluramid is designated by EPA as a New Pesticide Active Ingredient. Active Ingredient Number: 128992; Type of Pesticide: conventional-insecticide; Use Site: greenhouse ornamental/non-food areas; Year: 1989.

Used as insecticide for control of household ants and cockroaches; [HSDB]

For sulfluramid (USEPA/OPP Pesticide Code: 128992) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Sulfluramid is currently registered only for use as a termiticide in pre-filled bait stations (including perforated tubes and stakes) that are placed around building perimeters (residential, food establishments, and other institutions).

Used for household control of Formicidae /ants/ and Blattellidae /cockroaches/.

Insecticide

non-polymer PFAS -> Manufacture of Metal Products -> Treatment and coating of metal

Solid, pellets.

Principal tradename: Finitron (Griffin).

Technical is 98.0%.

Firstline Termite Bait Station (FMC Corp. Agricultural Products Group) Sulfluramid 0.01%.

For more Formulations/Preparations (Complete) data for SULFLURAMID (10 total), please visit the HSDB record page.

PFAS -> PFalkylsulfonamides (FASA)

PFAS (per- and polyfluoroalkyl substances) -> OECD Category

1-Octanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-: ACTIVE

In 2001, the Agency completed human health and ecological risk assessments to assess new proposed uses for products containing sulfluramid. Because of the potential toxicity concern resulting from bioaccumulation of the Perfluorooctane Sulfonate (PFOS) degradate in animals, as well as evidence of developmental and reproductive effects in toxicity studies, EPA negotiated in 2001 with all U.S. registrants a phase-out of products containing sulfluramid, with all registrations set to expire by December 31, 2016. Additionally, DuPont, the sole technical registrant, agreed to discontinue producing any new sulfluramid manufacturing-use product and the acquisition or importation of any additional sulfluramid into the U.S. At the beginning of the registration review process for sulfluramid in 2007, the technical registrant informed the Agency that they exhausted their sulfluramid supply; all remaining sulfluramid stocks were sold to the end-use registrants. The Agency issued the product cancellation order for the last remaining sulfluramid manufacturing-use product registration on May 16, 2008 (73 FR 28465-28469). Based on the remaining supply of sulfluramid stocks, the Agency renegotiated the phase-out terms with the end-use registrants so that all product registrations are to expire by December 31, 2012. End-use registrants will be permitted to sell the remaining stocks for one additional year after the expiration of the product registrations. Distributors and retailers are permitted to sell existing stocks of end-use sulfluramid products until all stocks in the supply chain are exhausted. Currently, there are seven remaining registered end-use products that contain sulfluramid as an active ingredient.

The WHO Recommended Classification of Pesticides by Hazard identifies sulfluramid (technical grade) as Class II: moderately hazardous; Main Use: insecticide.