Carrageenan

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Residues of Carrageenan conforming to 21 CFR 172.620 (minimum molecular weight: 100,000) are exempted from the requirement of a tolerance when used as a thickner in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Carrageenan conforming to 21 CFR 172.620 (not more than 0.15% of pesticide formulation) is exempted from the requirement of a tolerance when used as a thickener and stabilizer for pesticide formulation applied to seeds before planting in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.

Carrageenan conforming to 21 CFR 172.620 (minimum molecular weight: 100,000) is exempted from the requirement of a tolerance when used as a thickener in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals.

Daily subconjuctival injections or application of oily drops of thiotepa is reported to delay vascularization of /guinea pig corneas treated with carrageenin/ ... but not to prevent it.

IN RATS PRETREATED WITH INDOMETHACIN, INJECTION OF PROSTAGLANDIN E1 WITH CARRAGEENAN POTENTIATED CARRAGEENAN PAW EDEMA. THIS EFFECT OF PGE1 WAS MAXIMAL WHEN IT WAS INJECTED WITH CARRAGEENAN.

CARRAGEENAN INHIBITED IN VITRO RISTOCETIN-INDUCED HUMAN BLOOD PLATELET AGGREGATION.

256 WISTAR RATS RECEIVED A SINGLE INJECTION INTO THE RIGHT PLEURAL CAVITY OF UICC CROCIDOLITE TO INDUCE MESOTHELIOMAS. THEY WERE THEN GIVEN RIGHT INTRAPLEURAL INJECTIONS OF CARRAGEENAN. THERE WAS A 3-FOLD INCREASE IN MESOTHELIOMA INCIDENCE IN THE GROUP INJECTED WITH CARRAGEENAN.

ADDN OF CARRAGEENAN TO PLATELET-RICH PLASMA CAUSED 2-PHASE AGGREGATION. AT CONCN @ WHICH PLATELET AGGREGATION OCCURRED, CARRAGEENANS WERE ANTICOAGULANT WHEN EXAMINED IN PARTIAL THROMBOPLASTIN TIME ASSAYS.

CARRAGEENAN PROLONGED CLOTTING TIME IN PARTIAL THROMBOPLASTIN TIME (PTT) ASSAYS, INHIBITED AMIDOLYTIC ACTIVITY OF THROMBIN, & WAS WITHOUT EFFECT ON ACTIVATED BLOOD-COAGULATION FACTOR X-CATALYZED AMIDOLYSIS.

... Oral doses in man have induced no reported toxic reactions more serious than watery diarrhea.

GROUPS OF 5 MALE & 5 FEMALE MICE OF TWO UNIDENTIFIED STRAINS...MAINTAINED THROUGHOUT...LIFESPAN ON DIETS CONTAINING 1, 5, 15 OR 25% FOOD-GRADE NATIVE CARRAGEENAN ADDED TO DIET... NO EFFECT WAS NOTED WITH REGARD TO MORTALITY, BUT FOOD CONSUMPTION INCR...NO APPARENT PATHOLOGICAL EFFECTS ON GI TRACT, LIVER OR KIDNEYS.

/GROUPS OF 5 MALE & 5 FEMALE RATS OF TWO UNSPECIFIED STRAINS WERE MAINTAINED ON DIETS CONTAINING 1, 5, 15 OR 25% FOOD-GRADE NATIVE CARRAGEENAN/...FOOD CONSUMPTION /INCR/...IN ANIMALS FED 25%...SOME CASES OF HEPATIC CIRRHOSIS, ALTHOUGH NO CHANGE IN INTESTINAL TRACT, KIDNEYS OR LIVER IN ANIMALS FED LOWER DOSE LEVELS.

FEMALE WISTAR RATS, 60 DAYS OLD, RECEIVED SC INJECTIONS OF 5 ML 1% WT/VOL CARRAGEENAN IN 0.9% SALINE SOLN IN LEFT FLANK. ...OF 39 RATS SURVIVING 400 DAYS 11 DEVELOPED SARCOMAS ON LEFT SIDE & NONE ON RIGHT, WITHIN 825 DAYS. IN ALL OTHER EXPT IN WHICH CARRAGEENAN WAS INJECTED INTO LEFT FLANK, SARCOMAS...FOUND ONLY @ SITE.

ADMIN TO RHESUS MONKEYS OF 1% NATIVE CARRAGEENAN IN DRINKING-WATER, PROVIDING AN INTAKE OF 1.3 G/KG BODY WT FOR 7-14 WEEKS, PRODUCED NO ADVERSE EFFECT.

For more Non-Human Toxicity Excerpts (Complete) data for CARRAGEENAN GUM (19 total), please visit the HSDB record page.

Carrageenan is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient.

Carrageenan with polysorbate 80 is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient. /Carrageenan with polysorbate 80/

Salts of carrageenan is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient. /Salts of carrageenan/

Chondrus extract (carrageenin) is generally recognized as safe when used in accordance with good manufacturing practice.

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

Residues of Carrageenan conforming to 21 CFR 172.620 (minimum molecular weight: 100,000) are exempted from the requirement of a tolerance when used as a thickner in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Carrageenan conforming to 21 CFR 172.620 (not more than 0.15% of pesticide formulation) is exempted from the requirement of a tolerance when used as a thickener and stabilizer for pesticide formulation applied to seeds before planting in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.

Carrageenan conforming to 21 CFR 172.620 (minimum molecular weight: 100,000) is exempted from the requirement of a tolerance when used as a thickener in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals.