Isobutyl acrylate

0.889 at 68 °F (USCG, 1999) - Less dense than water; will float

0.8896 at 20 deg

Liquid heat capacity= 0.431 BTU/lb-F @ 70 °F; Liquid thermal conductivity= 1.048 BTU-in/hr-sq ft-F at 70 °F; Saturated vapor density= 0.00494 lb/cu ft @ 70 °F; Ideal gas heat capacity= 0.371 BTU/lb-F @ 75 °F

Slightly soluble (NTP, 1992)

Soluble in ethanol, ether and methanol

In water, 2,000 mg/L at 25 °C

86 °F (NTP, 1992)

86 °F (30 °C) (open cup)

270 °F at 760 mmHg (NTP, 1992)

132 °C

Boiling point: 61-63 °C (51 mm Hg)

-78 °F (USCG, 1999)

-61 °C

Odor Threshold Low: 0.002 [ppm]

2.00X10-3 ppm (odor detection in air, purity not specified)

9.00X10-3 ppm (odor recognition in air, purity not specified)

Warning

H226: Flammable liquid and vapor [Warning Flammable liquids]；H312: Harmful in contact with skin [Warning Acute toxicity, dermal]；H315: Causes skin irritation [Warning Skin corrosion/irritation]；H317: May cause an allergic skin reaction [Warning Sensitization, Skin]；H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P261, P264, P271, P272, P280, P302+P352, P303+P361+P353, P304+P340, P317, P321, P332+P317, P333+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 6.3% (37 of 583) of reports.

Chemical: 2-Propenoic acid, 2-methylpropyl ester

2-Propenoic acid, 2-methylpropyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenoic acid, 2-methylpropyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 23-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/13347

2-Propenoic acid, 2-methylpropyl ester: HSNO Approval: HSR001095 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious); polymerization hazard]:；HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids will float on water. (ERG, 2024)

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.；· Vapors may form explosive mixtures with air.；· Vapors may travel to source of ignition and flash back.；· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).；· Vapor explosion hazard indoors, outdoors or in sewers.；· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.；· Runoff to sewer may create fire or explosion hazard.；· Containers may explode when heated.；· Many liquids will float on water.

Moderate toxicity when swallowed. Contact with the eyes causes minor irritation no worse than that caused by hand soap. (USCG, 1999)

· May cause toxic effects if inhaled or absorbed through skin.；· Inhalation or contact with material may irritate or burn skin and eyes.；· Fire will produce irritating, corrosive and/or toxic gases.；· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.；· Runoff from fire control or dilution water may cause environmental contamination.

A skin sensitizer; [Quick CPC] May polymerize exothermically on exposure to heat or if contaminated; [CAMEO] High vapor concentrations can cause mild and temporary smarting of the eyes and respiratory tract; A mild eye irritant (no worse than hand soap); Prolonged skin contact may cause reddening; [CHRIS] An irritant; Inhalation may cause asthma symptoms or difficulty breathing; Toxic by skin absorption; Harmful by inhalation; [Aldrich MSDS] Isobutyl acrylate, stabilized (UN2527) has warning of explosive polymerization; [ERG 2016]

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Isobutyl acrylate is included on this list. Effective date 9/30/91; Sunset date 12/19/95.

Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 9/30/91; Reporting date 11/27/91.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious); polymerization hazard]:；CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.；SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).；LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.；FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.；· Keep unauthorized personnel away.；· Stay upwind, uphill and/or upstream.；· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.；· All equipment used when handling the product must be grounded.；· Do not touch or walk through spilled material.；· Stop leak if you can do it without risk.；· Prevent entry into waterways, sewers, basements or confined areas.；· A vapor-suppressing foam may be used to reduce vapors.；· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.；· Use clean, non-sparking tools to collect absorbed material.；Large Spill；· Dike far ahead of liquid spill for later disposal.；· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:；· Call 911 or emergency medical service.；· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.；· Move victim to fresh air if it can be done safely.；· Administer oxygen if breathing is difficult.；· If victim is not breathing:；-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.；-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).；-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.；· Remove and isolate contaminated clothing and shoes.；· For minor skin contact, avoid spreading material on unaffected skin.；· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.；· For severe burns, immediate medical attention is required.；· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.；· Keep victim calm and warm.；· Keep victim under observation.；· For further assistance, contact your local Poison Control Center.；· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.；Specific First Aid:；· Wash skin with soap and water.

This chemical is a combustible liquid. Poisonous gases are produced in fire. Use dry chemical, carbon dioxide, or foam extinguishers. Water may be ineffective. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined area may explode in fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If materials or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped.

Alcohol foam. Water may be ineffective.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. /Isobutyl acrylate, stabilized/

Evacuation: If fire becomes uncontrollable or container is exposed to direct flame-consider evacuation of one-third (1/3) mile radius.

Prior to working with this chemical you should be trained on its proper handling and storage. Before entering a confined space where hexanol may be present, check to make sure that an explosive concentration does not exist. Store in an explosion-proof cool area. Protect for air and light for long-term storage. Where possible, automatically pump liquid from drums or other storage containers to process containers.

The effectiveness of phenolic inhibitors is dependent on the presence of oxygen and the monomers must be stored under air rather than an inert atmosphere. Temp must be kept low to minimize formation of peroxides and other products. ... The acrylic esters may be stored in mild or stainless steel, or aluminum. /Acrylic acid & derivatives/

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorbent may be used to concolidate spills on land (such as sorbent polyurethane foams). Oil skimming equipment may be used for spills on water. Absorb liquids in vermiculite, dry sand, earth, or a similar non-organic materials and deposit in sealed containers. Kepp this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious); polymerization hazard]:；ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.；LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Wear protective gloves and clothing to prevent any reasonable probability of skin contact. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. Polyvinyl Alcohol is among the recommended protective materials. All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Contact lenses should not be worn when working with this chemical. Wear splash-proof chemical goggles and face shield unless full facepiece respiratory protection is worn. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash.

Awareness of the dangers and of good engineering design are essential to safety. Employees should be instructed about the necessity of cleansing the skin if it is contaminated by materials which are irritants or skin-absorbed. With careful design, however, and complete enclosure of those processes where toxic chemicals or intermediates occur, dangerous exposures can be avoided. /Acrylic acid & derivatives/

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors. /Isobutyl acrylate, stabilized/

Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Isobutyl acrylate, stabilized/

For more Preventive Measures (Complete) data for ISOBUTYL ACRYLATE (6 total), please visit the HSDB record page.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious); polymerization hazard]:；IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.；LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).；FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure；· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.；Large Spill；· Consider initial downwind evacuation for at least 300 meters (1000 feet).；Fire；· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Self-contained breathing apparatus, rubber gloves, chemical goggles. (USCG, 1999)

Where the potential for exposure to this chemical, use a MSHA/NIOSH approved supplied-air-respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self-contained breathing apparatus operated in a pressure-demand or other positive-pressure mode.

Self-contained breathing apparatus, rubber gloves, chemical goggles.

SUITABLE PROTECTIVE CLOTHING & SELF-CONTAINED RESP PROTECTIVE APPARATUS SHOULD BE AVAILABLE FOR USE OF THOSE WHO MAY HAVE TO RESCUE PERSONS OVERCOME BY FUMES. /ACRYLIC ACID & DERIVATIVES/

Protection required for safe handling of acrylic acid and esters commonly includes use of impervious gloves, shoe soles, and clothing; splash-proof goggles ... . /Acrylic acid & derivatives/

Personnel protection: Wear appropriate chemical protective gloves, boots and goggles. /Isobutyl acrylate, stabilized/

LC50 Pimephales promelas (Fathead minnows, 29 days old, mean length 18.5 mm, mean weight 0.1 g) 2.09 mg/L/96 hr (95% confidence limit 1.92-2.28 mg/L); flow through, 24.0 °C, hardness 45.3 mg/L (CaCO3), pH 7.61, dissolved oxygen 7.1 mg/L, alkalinity 49.8 mg/L (CaCO3) />97% purity/

EC50 Pimephales promelas (Fathead minnows, 29 days old, mean length 18.5 mm, mean weight 0.1 g) 1.90 mg/L/96 hr; flow through, 24.0 °C, hardness 45.3 mg/L (CaCO3), pH 7.61, dissolved oxygen 7.1 mg/L, alkalinity 49.8 mg/L (CaCO3); Effect:.Affected fish lost schooling behavior and swam near the tank surface in a corkscrew/spiral pattern. They were hyperactive and overreactive to external stimuli, had increased respiration and edema, and lost equilibrium prior to death. />97% purity/

LC50 Pimephales promelas (Fathead minnow, 29 days old, mean length 21.4 mm, mean weight 0.149 g) 2.11 mg/L/96 hr; flow through, 25.1 °C, hardness 44.0 mg/L (CaCO3), pH 7.7, dissolved oxygen 6.7 mg/L, alkalinity 43.8 mg/L (CaCO3) />97% purity/

EC50 Pimephales promelas (Fathead minnow, 29 days old, mean length 21.4 mm, mean weight 0.149 g) 2.11 mg/L/96 hr; flow through, 25.1 °C, hardness 44.0 mg/L (CaCO3), pH 7.7, dissolved oxygen 6.7 mg/L, alkalinity 43.8 mg/L (CaCO3); Effect: Affected fish lost schooling behavior, were hyperactive and swam near the tank surface, frequently in a corkscrew/spiral pattern. They were overreactive to external stimuli, had increased respiration, were edematous and lost equilibrium prior to death. />97% purity/

For more Ecotoxicity Values (Complete) data for ISOBUTYL ACRYLATE (9 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 66(SRC), determined from a water solubility of 2,000 mg/L(2) and a regression-derived equation(3), indicates that isobutyl acrylate is expected to have high mobility in soil(SRC). Volatilization of isobutyl acrylate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.0X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 7.07 mm Hg(4), and water solubility(2). Isobutyl acrylate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). By analogy to butyl acrylate, which reached 61% of its theoretical BOD in 2 weeks using an activated sludge inoculum in the Japanese MITI test(5), biodegradation of isobutyl acrylate may by an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 66(SRC), determined from a water solubility of 2,000 mg/L(2) and a regression-derived equation(3), indicates that isobutyl acrylate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 6.0X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 7.07 mm Hg(4), and water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4.6 hours and 117 hours, respectively(SRC). According to a classification scheme(5), an estimated BCF of 10(SRC), from a log Kow of 2.22(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). No hydrolysis data were available for isobutyl acrylate. A base-catalyzed second-order hydrolysis rate constant of 1.33X10-2 L/mole-sec(SRC) was estimated using a structure estimation method(8); this corresponds to half-lives of 1.6 years and 16.5 years at pH values of 8 and 7, respectively(8). By analogy to butyl acrylate, which reached 61% of its theoretical BOD in 2 weeks using an activated sludge inoculum in the Japanese MITI test(9), biodegradation of isobutyl acrylate may by an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isobutyl acrylate, which has a vapor pressure of 7.07 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isobutyl acrylate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.2 days(SRC), calculated from its rate constant of 1.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The rate constant for the vapor-phase reaction of isobutyl acrylate with ozone has been estimated as 0.18X10-17 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(4). This corresponds to an atmospheric half-life of about 6.5 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(5).

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=106-63-8]

The Koc of isobutyl acrylate is estimated as 66(SRC), using a water solubility of 2,000 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that isobutyl acrylate is expected to have high mobility in soil.

/SIGNS AND SYMPTOMS/ THE ACUTE TOXICITY OF THE ACRYLATES DECREASES WITH INCREASING MOLECULAR WEIGHT. ... HUMAN SIGNS & SYMPTOMS FOLLOWING INGESTION OF ACRYLIC MONOMERS INCL COLLAPSE, SEVERE RESPIRATORY DIFFICULTIES, & CNS STIMULATION. ACUTE INHALATION OF HIGHER CONCN MAY CAUSE MARKED IRRITATION, SALIVATION, CONJUNCTIVAL IRRITATION, & PRONOUNCED PULMONARY IRRITATION OR EDEMA. PROLONGED SKIN OR EYE CONTACT MAY RESULT IN SEVERE TISSUE DAMAGE. THE PATHOLOGY FROM SINGLE EXPOSURE IS NONSPECIFIC , CONTRARY TO REPEATED EXPOSURE EFFECTS, WHICH INCL PULMONARY CONGESTION OR HEMORRHAGE & CLOUDY SWELLING OF LIVER & KIDNEY. /ACRYLATES/

/OTHER TOXICITY INFORMATION/ ISOMERIZATION APPEARS TO DECR ORAL, BUT INCR DERMAL, TOXICITY.

Isobutyl acrylate's production and use as a comonomer in acrylic surface coatings, an intermediate for the production of polymers and as the monomer in synthetic resin manufacture(1) may result in its release to the environment through various waste streams(SRC).

AEROBIC: By analogy to butyl acrylate, which biodegrades readily in the MITI test(1), biodegradation of isobutyl acrylate may by an important environmental fate process(SRC). Butyl acrylate, present at 100 mg/L, reached 61% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1)..

An estimated BCF of 10 was calculated in fish for isobutyl acrylate(SRC), using a log Kow of 2.22(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for isobutyl acrylate is estimated as 6.0X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 7.07 mm Hg(1), and water solubility, 2,000 mg/L(2). This Henry's Law constant indicates that isobutyl acrylate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 4.6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 5 days(SRC). Isobutyl acrylate's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of isobutyl acrylate from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

/LABORATORY ANIMALS: Acute Exposure/ Acrylic acid isobutyl ester has been tested externally on the eyes of rabbits & ... rated 2 on scale of 1 to 10 according to the degree of injury observed after 24 hr. The most severely injurious substances have been rated 10.

/LABORATORY ANIMALS: Acute Exposure/ Contact sensitivity was produced in Guinea pigs with mono-, di-, and tri- acrylate compounds. /Mono-, di-, and tri- acrylate compounds/

/GENOTOXICITY/ Isobutyl acrylate was tested for mutagenicity in the Salmonella/microsome preincubation assay using a protocol approved by the National Toxicology Program. Isobutyl acrylate was tested over a wide range of doses (0, 100, 333, 1000, 3333, and 10,000 ug/plate) in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. Isobutyl acrylate was negative in these tests and the highest ineffective dose level tested in any Salmonella tester strain was 10,000 ug/plate.

/OTHER TOXICITY INFORMATION/ TOXICITY OF 6 ACRYLATES & 6 METHACRYLATES WAS DETERMINED IN FISH & RATS. ALL ESTERS WERE LESS TOXIC THAN ACRYLAMINE & ACRYLONITRILE. METHACRYLATES WERE APPROX 5-FOLD LESS TOXIC THAN ACRYLATES. TOXICITY FOR A GIVEN SERIES DECR WITH INCR LENGTH OF CARBON CHAIN.

/OTHER TOXICITY INFORMATION/ STRUCTURE-TOXICITY RELATIONSHIPS OF ACRYLATES, INCL ISOBUTYL ACRYLATE, & METHACRYLATES WERE ANALYZED IN MICE. ACUTE ORAL LD50, PARTITION COEFFICIENT (P), & 2ND ORDER RATE CONSTANT (K) MEASURED EXPTL. TOXICITIES FOUND TO BE DEPENDENT UPON LOG P OR LOG K, ESPECIALLY UPON LOG P.

Chemical: 2-Propenoic acid, 2-methylpropyl ester

2-Propenoic acid, 2-methylpropyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenoic acid, 2-methylpropyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 23-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/13347

2-Propenoic acid, 2-methylpropyl ester: HSNO Approval: HSR001095 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Isobutyl acrylate is included on this list. Effective date 9/30/91; Sunset date 12/19/95.

Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 9/30/91; Reporting date 11/27/91.

Used as a monomer in the production of acrylic resins; [HSDB] Used in organic synthesis, as latent solvent in paints and lacquers, as substitute for n-butyl alcohol, in paint removers, for fluorometric determinations, liquid chromatography, and in fruit flavor concentrates; [NTP] Used as comonomer for polymers used in surface coatings, films and pressure sensitive adhesives, dispersions, and construction materials; [OECD SIDS]

Painting (Pigments, Binders, and Biocides) [Category: Paint]；Working with Glues and Adhesives [Category: Other]

CHEMICAL INTERMEDIATE FOR POLYMERS; COMONOMER IN ACRYLIC SURFACE COATINGS

Used as a monomer in synthetic resin manufacture

Monomer for acrylate resins

... comonomer in acrylic surface coatings, an intermediate for the production of polymers and as the monomer in synthetic resin manufacture

2023: 5,000,000 - <10,000,000 lb；2022: 5,000,000 - <10,000,000 lb；2020: 5,000,000 - <10,000,000 lb

(1974) 7.3X10+9 G (EST - INCL OTHER ACRYLATES)

(1975) 9.08X10+9 G (EST-INCL OTHER ACRYLATES)

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#1714]

2-Propenoic acid, 2-methylpropyl ester is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

Reaction of acrylic acid with isobutyl alcohol (esterification)

ACRYLATES CAN BE PREPARED BY ... DEHYDRATION OF THE CORRESPONDING HYDROXYALKANOIC ACID, SAPONIFICATION OF THE ALKENE NITRILE, CATALYTIC HYDRATION OF ACETYLENE AND CARBON MONOXIDE, OR THE REACTION OF ACETONE WITH HYDROCYANIC ACID. /ACRYLATES/

In ... propylene oxidation process acrolein is first formed by the catalytic oxidation of propylene vapor at high temp in the presence of steam. The acrolein is then oxidized to acrylic acid. ... The acrylic acid is esterified with alcohol to the ... acrylic ester in a separate process. /Acrylic ester monomers/

Grades of purity: 99.0%

Inhibitor of polymerization: Methyl ether of hydroquinone: 10-60 ppm; hydroquinone: 5 ppm

... Contains 100 ppm monomethyl ether hydroquinone as inhibitor.

Paint and Coating Manufacturing

2-Propenoic acid, 2-methylpropyl ester: ACTIVE

POLYISOBUTYL ACRYLATE IS HIGHLY USEFUL COMPONENT IN COPOLYMERIZATION REACTIONS & SERVES AS MOST PREFERRED VISCOSITY INDEX IMPROVER IN PETROLEUM INDUSTRY. /POLYISOBUTYL ACRYLATE/

... POLYMERIZED ESTERS ... ESP METHYL, ETHYL & BUTYL ESTERS, ARE KNOWN UNDER TRADE NAMES OF "LUCITE", "PLEXIGLAS", & "PERSPEX", & ARE OF CONSIDERABLE COMMERCIAL IMPORTANCE. THEY ARE WIDELY USED AS SUBSTITUTES FOR GLASS & IN CERTAIN SITUATIONS ARE PREFERRED TO IT SINCE THEY ARE ALMOST AS TRANSPARENT AS GLASS BUT WEIGH ONLY HALF AS MUCH. ... WHERE HIGH OPTICAL ACCURACY IS NOT REQUIRED THEY CAN ALSO BE MADE INTO LENSES. THIS ORGANIC GLASS HAS PROPERTY OF TOTAL INTERNAL REFLECTION & CAN "PIPE" LIGHT ... USEFUL FOR SURGICAL RETRACTORS & THROAT LIGHTS. ... WIDELY USED FOR DENTURES, ARTIFICIAL EYES & SURGICAL PROSTHESES. THE POLYMERS MAY BE CAST INTO SHEETS OR MOULDED ... . /ACRYLIC ACID DERIVATIVES/