Hydroxylamine

Fire Extinguishing Agents: Use extreme caution - material may explode. Use remote extinguishing equipment or unmanned fixed turret and hose nozzles - evacuate area. (USCG, 1999)

Use water in large amounts, alcohol-resistant foam, powder. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Use water, alcohol-resistant foam, powder. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Fresh air, rest. Administration of oxygen may be needed. Refer immediately for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention .

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Administration of oxygen may be needed. Refer immediately for medical attention.

Fresh air, rest. Administration of oxygen may be needed. Refer immediately for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention .

Fireproof. Separated from incompatible materials. See Chemical Dangers. Cool. Dry. Well closed. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

Fireproof. Separated from incompatible materials. See Chemical Dangers. Cool. Well closed. Do not allow to dry out. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

Not combustible. Extinguish fire using agent suitable for surrounding fire. Fight fire from protected location or maximum possible distance. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Explosive decomposition may occur under fire conditions.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered non-metallic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: filter respirator for inorganic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered non-metallic containers as far as possible. Absorb remaining liquid in inert absorbent. Then store and dispose of according to local regulations.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

MATERIAL SHOULD BE HANDLED WITH CAUTION TO AVOID CONTACT & COMPLETE ELIMINATION OF MANUAL PROCESSES BY MECHANIZATION IS RECOMMENDED.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 14(SRC), determined from a structure estimation method(2), indicates that hydroxylamine is expected to have very high mobility in soil(SRC). The pKa of hydroxylamine is 5.94(3) which indicates this compound will partially exist as a cation under acidic conditions, and cations have lower mobility in soil than neutral species(SRC). Volatilization of hydroxylamine from moist soil surfaces is not expected to be an important fate process since cations do not volatilize(SRC) and the neutral species has an estimated Henry's Law constant of 6.9X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The potential for volatilization of hydroxylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 53 mm Hg(5) at 32 °C.

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 14(SRC), determined from a structure estimation method(2), indicates that hydroxylamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 5.94(3) indicates hydroxylamine will partially exist as a cation in waters. Volatilization from water surfaces is not expected to be an important environmental fate process(SRC) since cations do not volatilize and the Henry's Law constant of the neutral species is 6.9X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of 1.2(6,SRC) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hydroxylamine, which has a vapor pressure of 53 mm Hg at 32 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hydroxylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 hours(SRC), calculated from its rate constant of 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3).

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Cough. Sore throat. Dizziness. Headache. Blue lips, fingernails and skin. Shortness of breath. Weakness.

MAY BE ABSORBED! Redness. Pain. Further see Inhalation.

Redness. Pain. Severe burns.

Nausea. Vomiting. Symptoms may be delayed. Further see Inhalation.

Cough. Sore throat. Dizziness. Headache. Blue lips, fingernails and skin. Shortness of breath. Weakness.

MAY BE ABSORBED! Redness. Pain. Further see Inhalation.

The substance is very toxic to aquatic organisms.

The substance is very toxic to aquatic organisms.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for hydroxylamine can be estimated to be 14(SRC). According to a classification scheme(2), this estimated Koc value suggests that hydroxylamine is expected to have very high mobility in soil. A pKa of 5.94(3) indicates that hydroxylamine will partially exist in the protonated form in moist soils(SRC) and cations adsorb to soil stronger than neutral compounds.

HYDROXYLAMINE & ITS SALTS ARE CORROSIVE TO SKIN & HIGHLY IRRITANT TO EYES & MUCOUS MEMBRANES. REPEATED EXPOSURE MAY ENHANCE ALLERGIC REACTION PARTICULARLY OF...HANDS & FOREARMS FROM 1-2 WK TO 2-5 YEARS AFTER COMMENCEMENT OF EXPOSURE & CASES OF ECZEMA...OBSERVED FOLLOWING PROLONGED CONTACT.

CORROSIVE TO SKIN. ... MAY CAUSE METHEMOGLOBINEMIA.

SOLN HAS CORROSIVE ACTION ON SKIN. /HYDROXYLAMINE SULFATE/

...IN WORKERS. ...INCREASES OF METHEMOGLOBIN CONTENT OF BLOOD BY UP TO 25% HAVE BEEN REPORTED AT THE END OF THE WORKING DAY.

For more Human Toxicity Excerpts (Complete) data for HYDROXYLAMINE (6 total), please visit the HSDB record page.

An estimated BCF of 3 was calculated for hydroxylamine(SRC), using an estimated log Kow of -1.2(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The pKa for hydroxylamine is 5.94(1), which indicates this compound will partially exist in the protonated form(SRC). Volatilization from moist soils and water surfaces is not expected since cations don't volatilize and the estimated Henry's Law constant for the neutral species is 6.9X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(2). The potential for volatilization of hydroxylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 53 mm Hg(3).