7-Hydroxycitronellal

Cosmetics ingredient -> Base; Flavor; Fragrance; Moisturizing/Humectant; Other (Specify)

Masking

slightly

slightly soluble in water; soluble in alcohol, propylene glycol, and oils; insoluble in glycerol

1 ml in 1 ml 50% alcohol (in ethanol)

241.00 °C. @ 760.00 mm Hg

241 °C; 94-96 °C (1 mm Hg)

Liquid; Dry Powder; Liquid; CBI

Liquid; [Sigma-Aldrich MSDS]

colourless liquid with sweet floral lily-like odour

This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2046) of reports.

Warning

H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2046 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

Chemical: Octanal, 7-hydroxy-3,7-dimethyl-

Hazard Traits - Fragrance Allergen

Octanal, 7-hydroxy-3,7-dimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Octanal, 7-hydroxy-3,7-dimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 15-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/12695

Hydroxycitronellal: Does not have an individual approval but may be used under an appropriate group standard

A severe eye and moderate skin irritant; Causes cutaneous sensitization in 3-day intermittent dermal studies of mice; [RTECS] Fragrance ingredient that is a recognized contact allergen in consumers; [EC: SCCNFP] Safe when used as a flavoring agent in food; [JECFA] Contained in fragrance mix; [Kanerva, p. 1803] An irritant; [Sigma-Aldrich MSDS] See Citronellal.

Skin Sens. 1 (> 99.9%)

Eye irritation - category 2A

Serious eye damage/eye irritation - Category 2

Studies in rabbits have shown that hydroxycitronellal is converted to two primary metabolites: reduction to the alcohol 7-hydroxycitronellol and oxidation to the carboxylic acid 7-hydroxycitronellylic acid. On average, about 50% of hydroxycitronellal is excreted as 7-hydroxycitronellylic acid which is therefore regarded as the major metabolite.

8SQ0VA4YUR

HYDROXYCITRONELLAL

Established Pharmacologic Class [EPC] - Standardized Chemical Allergen

Physiologic Effects [PE] - Increased Histamine Release

Physiologic Effects [PE] - Cell-mediated Immunity

Chemical Structure [CS] - Allergens

Hydroxycitronellal

Hydroxycitronellal; Citronellalhydrate; 7-Hydroxy-3,7-dimethyloctanal; 3,7-Dimethyl-7-hydroxyoctanal; Octanal, 7-hydroxy-3,7-dimethyl-; Oxydihydrocitronellal; Laurinal (commercial name); Laurine (commercial name)

IFRA_STD_043.pdf

51

IFRA 51st Amendment - Guidance for the use of IFRA Standards

Restriction: This material should be used only in the limited quantity as stated in the Standard

Cosmetics product ingredient: Hydroxycitronellal (7-Hydroxycitronellal)

Information on 159 consumer products that contain Hydroxycitronellal in the following categories is provided:

Fragrance Ingredients

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Soap, Cleaning Compound, and Toilet Preparation Manufacturing

Octanal, 7-hydroxy-3,7-dimethyl-: ACTIVE

0.38 [Products applied to the lips]

0.11 [Products applied to the axillae]

2.2999999999999998 [Products applied to the face/body using fingertips]

2.1 [Products related to fine fragrances]

0.53 [Products applied to the body using the hands (palms), primarily leave-on (Body lotion)]

0.53 [Products applied to the face using the hands (palms), primarily leave-on (Face moisturizer)]