| GHS-Einstufung | WarningH226: Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (2 of 9011) of reports.H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids] |
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| Regulatorische Informationen | Chemical: 2-Propanol, 1-methoxy-Hazard Traits - Hepatotoxicity and Digestive System ToxicityNeurotoxicity2-Propanol, 1-methoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propanol, 1-methoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 28-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/146732-Propanol, 1-methoxy-: HSNO Approval: HSR001187 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| Weitere Sicherheitsinformationen | IMAP assessments - 2-Propanol, 1-methoxy-: Human health tier I assessment |
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| DOT-Kennzeichnung | Flammable Liquid |
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| Brandgefahren | FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. (USCG, 1999)· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.Flammable. Above 38 °C explosive vapour/air mixtures may be formed. |
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| Brandpotenzial | Moderate, when exposed to heat or flame |
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| Gesundheitsgefahren | VAPOR: Irritating to eyes, nose, and throat. LIQUID: Irritating to skin and eyes. (USCG, 1999)· May cause toxic effects if inhaled or absorbed through skin. |
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| Gefahrenübersicht | Rats inhaling 3000 ppm, 6 hours/day for 9 days, show signs of sedation, but tissue examination shows no evidence of gross or microscopic disease. Similarly exposed rats had increased liver weights after 6 monthsHuman volunteers exposed to 2500 ppm had severe lacrimation and painful breathingIn another human experiment, subjects complained of slight eye effects at 150 ppm, but not at 100 ppmTLV Basis is eye and upper respiratory tract irritation[ACGIH] A lachrymator[CHEMINFO] A skin, eye, and respiratory tract irritantInhalation of high concentrations can cause CNS depression[ICSC] See Glycol ethers. |
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| DOT-Nummer und Handbuch | 3092 129 |
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| Reaktive Gruppe | Alcohols and Polyols |
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| EG-Einstufung | R: 10S: (2)-24 |
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| UN-Einstufung | UN Hazard Class: 3UN Pack Group: III |
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| TSCA-Anforderungen | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1-Methoxy-2-propanol is included on this list. Effective date: 4/13/89Sunset date: 6/30/98. |
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| Brandbekämpfung | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Rest. Refer for medical attention . |
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| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
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| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.General First Aid:(General first aid procedures) |
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| Sichere Lagerung | Fireproof. Cool. Keep in the dark. |
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| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA).100.0 [ppm] |
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| Brandbekämpfungsverfahren | Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Use water spray to cool unopened containers.Wear self-contained breathing apparatus for firefighting if necessary. |
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| Lagerbedingungen | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Air sensitive. Forms explosive peroxides on prolonged storage. may form peroxided on contact with air. |
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| Reinigungsverfahren | Use personal protective eqipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignitino. Beware of vapors accumulating to form explosive concentrations.Prevent further leakage or spillage if safe to do so. Do not let product enter drains.Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. |
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| Freisetung ohne Brand | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: |
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| Entsorgungsverfahren | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal. |
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| Verschüttetes entsorgen | Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water. |
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| Körperbelastung | Six volunteers exposed for 8 hours to 100 ppm of 1-methoxy-2-hydroxypropane had maximum urine, blood and exhaled air concentrations of 110 mumol/L, 103 mumol/L and 252 nmol/L of 1-methoxy-2-hydroxypropane, respectively(1). The urine excretion half-life for 1-methoxy-2-hydroxypropane was <2.6 hours(1).1-Methoxy-2-hydroxypropane was measured in 6 volunteers exposed at 3 different concentrations over a 6 hour time period with and without respirators(1). The concentration of 1-methoxy-2-hydroxypropane in dermal exposed experiments was <0.1 ppm, < 1 mg/L and <1 mg/L in exhaled air, blood and urine, respectively. The excretion half-life in urine was 3.5 hours and 10 minutes in exhaled air. The concentrations of 1-methoxy-2-hydroxypropane in volunteers not using respirators were(1):[Table#2686] |
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| Wechselwirkungen | 1-Methoxy-2-propanol showed ... synergism to allethrin for knockdown ... against adult housefly. |
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| Zielorgane | NervousEyes, skin, respiratory system, central nervous system |
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| Ökotoxizitätswerte | LC50Species: Pimephales promelas (Fathead minnow)Concentration: >20.8 g/L for 96 hr /Conditions of bioassay not specified in source examined/Species: Leuciscus idus (Golden orfe)Concentration: >4500 mg/L for 96 hr /Conditions of bioassay not specified in source examined/EC50Species: Selenastrum capricornutum (Algae)Concentration: >1,000 mg/L for 7 daysEffect: growth inhibition /Conditions of bioassay not specified in source examined/Species: Daphnia magna /(Water flea)/Conditions: staticConcentration: 23.3 g/L for 48 hr |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1-methoxy-2-hydroxypropane is expected to have very high mobility in soil(SRC). Volatilization of 1-methoxy-2-hydroxypropane from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 9.2X10-7 atm-cu m/mole(3). 1-Methoxy-2-hydroxypropane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 12.5 mm Hg at 25 °C(4). Aerobic degradation using a sandy loam soil resulted in half-lives of <1 and <7 days at 0.2 and 100 ppm, respectively(5), indicating that biodegradation may be an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1-methoxy-2-hydroxypropane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 9.2X10-7 atm-cu m/mole(4). 1-Methoxy-2-hydroxypropane is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of -0.49(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 90% of theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-methoxy-2-hydroxypropane, which has a vapor pressure of 12.5 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-methoxy-2-hydroxypropane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 21 hours(SRC), calculated from its rate constant of 1.86X10-11 cu cm/molecule-sec at 25 °C(3). 1-Methoxy-2-hydroxypropane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
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| Unerwünschte Wirkungen | Neurotoxin - Acute solvent syndrome |
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| Expositionspfade | The substance can be absorbed into the body by inhalation of its aerosol or vapour, through the skin and by ingestion.inhalation, ingestion, skin and/or eye contact |
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| Toxizitätsübersicht | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgIDENTIFICATION AND USE: In the literature 1-methoxy-2-propanol is often referred to as propylene glycol monomethyl ether (PGME). Commercial PGME (CAS 130-67-8) typically contains at least 98.5% 1-methoxy-2-propanol (alpha isomer) and only 1.5% of 2-methoxy-1-propanol (beta isomer). PGME is a colorless liquid, miscible with water and many organic solvents. This makes it useful for a wide variety of solvent applications in the manufacture of lacquers, paints, dyes, inks, cleaning agents and liquid soaps. HUMAN EXPOSURE AND TOXICITY: PGME alpha (1-methoxy-2-propanol) has low toxicity. In male volunteers, following exposure to 100 ppm of PGME the subjects felt that the odor was too strong to be tolerated, but odor tolerance developed within 25 min. During a 3.5-hr exposure at 100 ppm, mild eye irritation was noted in 3 of the 6 individuals. At 250 ppm, the majority of the 23 subjects exposed for 1-7 hr complained of eye, nose or throat irritationseveral subjects developed headaches, and one was nauseated. None of the exposures resulted in changes in visual, coordination, neurological or brake-reaction tests. Clinical studies (e.g., blood cell count, SGOT, SGPT, BUN and complete urinalysis) completed before and after exposure showed no effects. In vitro testing in primary cell cultures of nasal respiratory epithelia of healthy individuals showed that 1-methoxy-2-propanol induces the transcription of genes encoding proinflammatory cytokines and mediators but largely not translation of thosesuggesting the existing exposure limits seem to be safe with respect to inflammatory responses of the upper respiratory tract. ANIMAL STUDIES: 1-Methoxy-2-propanol was not a skin sensitizer in guinea-pigs following 24 or 48 hour exposure and did not cause skin irritation when tested in rabbits. It was classifed as mildly irritating to rabbit eyes. The effects from iv injection in dogs were those of pain at the site of injection, shallow breathing, decreased blood pressure, auricular arrhythmia, and death due to convulsions. A decreased growth rate was seen in rats exposed to 10,000 ppm for 4 hr/day, 5 days/wk for 2 weeks. Large dermal doses in rabbits produced CNS depression and death. A slight increase in kidney weights was also noted in rabbits exposed to 10 mL/kg beneath bandages clipped to abdomens for a 90 day period (65 doses). In rats exposed to 0, 300, 1000, or 3000 ppm (0, 1.09, 3.62, or 10.9 mg/L) of PGME for 6 hr/day, 5 days/wk, for 13 weeks had hepatocellular hypertrophy but were without evidence of degenerative changes. There was an increase in the urinary pH of male rats exposed to 3000 ppm PGME for 4 weeks. Studies in laboratory animals indicate that PGME is not carcinogenicthere were no increases in tumors in any tissue in a 2-year study of male and female mice exposed to PGME via inhalation. PGME has resulted in developmental and reproductive toxicity. In a rat 2-generation reproduction study exposed to 3000 ppm of PGME vapors via inhalation for 6 hours/day, 5 days/week prior to mating, and 6 hours/day, 7 days/week during mating, gestation, and lactation, for 2 generations had toxicity in the P1 and P2 adults, as evidenced by sedation during and after exposure, and mean body weights which were as much as 21% lower than controls. This was accompanied by lengthened estrous cycles, decreased fertility, decreased ovary weights, and histologic ovarian atrophy in maternal rats. In the offspring from these dams, decreased body weights, reduced survival and litter size, slight delays in puberty onset, and histologic changes in liver and thymus in the F1 and F2 offspring were observed. No reproductive/neonatal effects were observed at 1000 ppm. In multiple studies, PGME fed to mice, rats, and rabbits during gestation resulted in delayed ossification of the skull only in the rat fetusa delayed ossification of the skull, at the highest dose. PGME was negative in the Ames Salmonella/mammalian-microsome bacterial mutagenicity assay (Ames test) using tester strains TA98, TA100, TA1535, TA 1537 and TA1538 and PGME was non-clastogenic to CHO cells in culture. |
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| Signs and Symptoms | Cough. Drowsiness. Headache. Sore throat.Dry skin. Redness.Watering of the eyes. Redness. Pain.Drowsiness. Headache. Nausea.irritation eyes, skin, nose, throatheadache, nausea, dizziness, drowsiness, incoordinationvomiting, diarrhea |
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| Ongoing Test Status | EPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assaysClick on the "Chemical Explorer" button on the tool bar to see the data./[USEPAICSS Dashboard ApplicationAvailable from, as of April 22, 2015: http://actor.epa.gov/dashboard/] |
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| Effluent Concentrations | 1-Methoxy-2-hydroxypropane was detected in effluents of advanced wastewater treatment plants in Lake Tahoe and Pomona, CA, Dallas, TX, and Washington, DC(1). 1-Methoxy-2-hydroxypropane was found in the waste gases from semiconductor fabricators(2). 1-Methoxy-2-hydroxypropane was detected in emissions from 5 of 44 furniture coatings tested(3). 1-Methoxy-2-hydroxypropane had an emission rate of 5.0X10+4 ug/hour from a spray carpet cleaner(4). |
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| EPA IRIS Information | Propylene glycol monomethyl ether (PGME)Nervous2 mg/m^3 |
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| Berufliche Expositionsstufe (OEB) | A |
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| Arbeitsplatzgrenzwert (OEL) | TWA: 100 ppm (360 mg/m3), STEL: 150 ppm (540 mg/m3) |
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| Wassergefährdungsklasse (WGK) | 1 |
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| TSCA-Inventar-Status | TSCA listed |
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| UN-Transportnummer | UN 3092 |
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| Zollcode | 29094919 |
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| RTECS-Nr. | UB7700000 |
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| R-Sätze (R) | 10-67-61 |
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| Toxizität | dog,LD50,intravenous,2gm/kg (2000mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: ATAXIABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972. |
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| Gefahrensymbole | T |
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| Sicherheitshinweise (S) | 24-26-24/25-45-53 |
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| Gefahrenklasse | 3Flam. Liq. 3STOT SE 3 |
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| Verpackungsgruppe | III |
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| Lagerklasse | 3 - Flammable liquids |
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| Gefahrstoffdaten | 107-98-2(Hazardous Substances Data) |
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| Selbstentzündungstemperatur | 532 °F |
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