Isopropylacetat

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

Use alcohol-resistant foam, foam, powder, carbon dioxide, fine water spray. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

(General first aid procedures)

· Wear positive pressure self-contained breathing apparatus (SCBA).

100.0 [ppm]

Extinguish with dry chem, /alcohol/ foam, or carbon dioxide. Water may be ineffective. Cool exposed containers with water.

Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities. Apply water from as far a distance as possible.

STORAGE TANKS ... SHOULD BE SITUATED IN A MOUNDED COMPOUND CONSTRUCTED TO RETAIN MAX QUANTITY OF LIQUID THAT COULD ESCAPE FROM TANKS; DRUMS & OTHER SMALLER RECEPTACLES ... SHOULD BE KEPT IN STOREROOM OF FIRE-RESISTANT CONSTRUCTION WITH MOUNDED & RAMPED DOORWAY TO PREVENT ESCAPE OF SPILT LIQUID. /ESTERS/

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

1. By absorbing it in vermiculite, dry sand, earth or a similar material and disposing in a secured sanitary landfill. 2. By atomizing in a suitable combustion chamber.

Isopropyl acetate is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.

The following wastewater treatment technologies have been investigated for isopropyl acetate: Concentration process: Activated carbon.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a water solubility of 29,000 mg/l(2) and a regression-derived equation(3), indicates that isopropyl acetate is expected to have very high mobility in soil(SRC). Volatilization of isopropyl acetate from moist soil surfaces is expected to be important(SRC) given a Henry's Law constant of 2.78X10-4 atm-cu m/mole(4). The potential for volatilization of isopropyl acetate from dry soil surfaces may exist(SRC) based on a vapor pressure of 60.4 mm Hg(5,SRC). Isopropyl acetate was determined to have a 5 day BOD of 61% using a settled domestic wastewater seed, and BOD's of 72%, 74% and 76% after 10, 15 and 20 days, respectively(6). When the same inoculum was added to synthetic sea water, the 5, 10, 15 and 20 day BOD's were 14%, 39%, 43%, 49%, respectively(6).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a water solubility of 29,000 mg/l(2,SRC) and a regression-derived equation(3), indicates that isopropyl acetate is not expected to adsorb to suspended solids and sediment in water(SRC). Isopropyl acetate is expected to volatilize from water surfaces(3,SRC) based upon a Henry's Law constant of 2.78X10-4 atm-cu m/mole(4,SRC). Estimated volatilization half-lives for a model river and model lake are 6 hours and 5 days, respectively(3,SRC). A base-catalyzed second-order hydrolysis rate constant of 9.1X10-2 L/mol-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 2.4 years and 88 days at pH values of 7 and 8, respectively(2,SRC). According to a classification scheme(6), an estimated BCF of 2(3,SRC), from the water solubility(2,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Isopropyl acetate was determined to have a 5 day BOD of 61% using a settled domestic wastewater seed, and BODs of 72%, 74% and 76% after 10, 15 and 20 days, respectively(7). When the same inoculum was added to synthetic sea water, the 5, 10, 15 and 20 day BOD's were 14%, 39%, 43%, 49%, respectively(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isopropyl acetate, which has a vapor pressure of 60.4 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isopropyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 4.6 days(3,SRC).

Isopropyl acetate has been identified as a component of Concord grape juice essence(1). It was detected in a headspace analysis of intact nectarines, but it was not found in samples of the blended fruit(2). Isopropyl acetate was identified as a volatile flavor component of Kogyoke apples(3).

ISOPROPYL ACETATE IS REPORTED TO BE USED IN NON-ALCOHOLIC BEVERAGES @ 16 PPM, IN ICE CREAM, ICES, ... @ 17 PPM, IN CANDY @ 58 PPM, & IN BAKED GOODS @ 75 PPM.

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

inhalation, ingestion, skin and/or eye contact

Cough. Sore throat. Headache. Drowsiness.

Redness. Dry skin.

Redness. Pain.

See Inhalation.

irritation eyes, skin, nose; dermatitis; In Animals: narcosis

The Koc of isopropyl acetate is estimated as approximately 15(SRC), using a measured water solubility of 29,000 mg/l(1) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that isopropyl acetate is expected to have very high mobility in soil(SRC).

URBAN/SUBURBAN: Isopropyl acetate was detected in 1 of 4 samples in the air surrounding the Kin-Buc Waste Disposal site, NJ, 1976, at an estimated concn of 6.5 ug/cu-m(1). Isopropyl acetate was qualitatively detected in the air of the Netherlands and it was described as one of the principal compounds emitted to the air(2). SOURCE DOMINATED: Isopropyl acetate was found in air samples obtained in the industrialized Kanawha Valley, WV, 1977, concn unknown(3).

Isopropyl acetate is an indirect food additive for use only as a component of adhesives.

Isopropyl acetate is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Isopropyl acetate is produced, as an intermediate or final product, by process units covered under this subpart.