Essigsäureanhydrid

Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]:

Use alcohol-resistant foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Wear protective gloves when administering first aid. Refer immediately for medical attention.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

(General first aid procedures)

Hazardous decomposition products formed under fire conditions. - Carbon oxides

Flash back along vapor trail may occur.

· Wear positive pressure self-contained breathing apparatus (SCBA).

0.1 [ppm]

Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Use flooding quantities of water.

Carbon dioxide, dry chemical, water mist, alcohol foam.

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary. Use water spray to cool unopened containers.

Store in cool, dry, well-ventilated location. Outside or detached storage is preferred. Store away from heat, oxidizers, and sunlight. Exclude moisture from vapor space in storage tanks.

Store away from ... foods, nitric acid, sodium peroxide.

Keep away from moisture and all alkalies.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Remove all ignition sources; Ventilate area of spill or leak; For small quantities, absorb on paper towels. Evaporate in a safe place. Allow sufficient time for evaporating vapors to completely clear the hood ductwork.

Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Control runoff and isolate discharge material for proper disposal. Neutralize spill and washings with soda ash or lime.

ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Absorb /acetic anhydride/ in vermiculite, dry sand, earth or a similar material and /dispose of/ it in a secured sanitary landfill. Atomize in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

/Small quantities can be absorbed on paper./ ... Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. Acetic anhydride should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Aerosol of acetic acid and acetic anhydride was released for a reactor in an industrial accident exposing workers. All exposed workers complained of severe conjunctival and naso-pharyngeal irritation, harsh cough, and some dyspnea. Of the 18 workers exposed, 14 were admitted to the hospital showing intense conjunctivities and acute pharyngo-laryngitis. Twelve showed numerous corneal abrasions, 11 presented necrotic areas in the nasal mucosa, and 12 showed spastic bronchitis. Two workers suffered first and second degree burns on the legs. Complete recovery occurred in 5-25 days.

TERRESTRIAL FATE: Acetic anhydride is expected to hydrolyze on moist soil to acetic acid(SRC). The half-life for the hydrolysis of acetic anhydride is 4.4 minutes(SRC), based on a rate constant of 0.002625 1/sec at 25 °C(1). The potential for volatilization of acetic anhydride from dry soil surfaces may exist(SRC) based upon a vapor pressure of 5.1 mm Hg(2).

TERRESTRIAL FATE: When spilled onto /dry/ soil, acetic anhydride will readily infiltrate downward ...

AQUATIC FATE: Acetic anhydride is expected to undergo rapid hydrolysis in the environment given a hydrolysis half-life of 4.4 minutes(SRC), based on a rate constant of 0.002625 1/sec at 25 °C(1). Bioconcentration of acetic anhydride in aquatic organisms is unlikely due its rapid hydrolysis(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), acetic anhydride, which has a vapor pressure of 5.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase acetic anhydride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 190 days(SRC), calculated from its rate constant of 8.4X10-14 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Acetic anhydride does not absorb light with wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

ATMOSPHERIC FATE: Since acetic anhydride is a relatively non-volatile liquid, direct venting of the vapor to the atmosphere from a hole in a ruptured vessel does not consitiute a significant hazard downwind. Vapor may be released from a liquid pool spilled on a ground or water surface.

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

inhalation, ingestion, skin and/or eye contact

IDENTIFICATION AND USE: Acetic anhydride ia a colorless liquid with a strong acetic odor. It is used in manufacture of acetyl compounds, cellulose acetates. The other applications include uses as acetylizer and solvent in examining wool fat, glycerol, fatty and volatile oils, resins; detection of rosin. It is widely used in organic synthesis, as dehydrating agent in nitrations, sulfonations and other reactions where removal of water is necessary. To reduce heroin availability, the United Nations has encouraged nations to control acetic anhydride, an essential ("precursor") chemical typically necessary to the drug's production. HUMAN STUDIES: Known to be a severe eye and skin irritant. Severe burns and vesiculation of human skin have been reported from liquid splashes, and concentrated vapor produces primary irritation. The immediate effect of exposure at vapor concentrations above 5 ppm is acute irritation of the eye. Inhalation can cause nasopharyngeal and upper respiratory tract irritation, with burning sensations, cough and dyspnea. Prolonged exposure may lead to pulmonary edema and death. ANIMAL STUDIES: Inhalation of 2000 ppm by rats for 4 hours caused deaths. It caused severe eye burns in rabbits. Rats were exposed to inhalation of vapors containing 0, 1, 5, or 20 ppm acetic anhydride for 6 hr/day, 5 days per week for 13 weeks. Clinical observations of eye and respiratory tract irritation and reduced body weights were observed primarily at 20 ppm. Inhalation exposure of pregnant female rats to 0, 25, 100, or 400 ppm 6 hr/day during days 6-15 of gestation caused fetotoxicity in a screening study with female rats exposed to the highly irritating, maternally toxic dose of 100 ppm vapor during gestation. In maternal animals at 100 ppm, severe respiratory tract irritation and body weight reduction were observed, and at 25 ppm substantial irritation of the respiratory tract was observed. No developmental effects were seen at 25 ppm even though substantial irritation of the respiratory tract was observed in maternal animals. Acetic anhydride was negative for mutagenicity in five Salmonella typhimurium strains (TA1535, TA1537, TA97, TA98, and TA100) in the presence and absence of metabolic activation. ECOTOXICITY STUDIES: The results of various laboratory tests with aquatic organisms, in which the toxic threshold concentrations for acetic anhydride were found to be about half those for acetic acid, suggest an initial toxic effect, so long as not all of the substance has hydrolyzed to acetic acid (during the first few minutes).

/AQUATIC SPECIES/ The results of various laboratory tests with aquatic organisms, in which the toxic threshold concentrations for acetic anhydride were found to be about half those for acetic acid, suggest an initial toxic effect, so long as not all of the substance has hydrolyzed to acetic acid (during the first few minutes).

Sore throat. Cough. Burning sensation in the throat and chest. Shortness of breath. Chest pain. Laboured breathing. Symptoms may be delayed.

Redness. Pain. Serious skin burns. Blisters.

Redness. Watering of the eyes. Pain. Severe burns. Corneal damage.

Burns in mouth and throat. Abdominal pain. Vomiting. Diarrhoea. Severe thirst. Shock or collapse.

conjunctivitis, lacrimation (discharge of tears), corneal edema, opacity, photophobia (abnormal visual intolerance to light); nasal, pharyngeal irritation; cough, dyspnea (breathing difficulty), bronchitis; skin burns, vesiculation, sensitization dermatitis

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of July 27, 2017: http://actor.epa.gov/dashboard/]

The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for acetic anhydride is available.[Available from, as of July 26, 2017: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]

Initial Medical Screening-Chronic Respiratory Disease: In persons with impaired pulmonary function, especially those with obstructive airway diseases, the breathing of acetic anhydride might cause exacerbation of symptoms due to its irritant properties. Skin disease: Acetic anhydride is a primary skin irritant. Persons with pre-existing skin disorders may be more susceptible to the effects of this agent. Eye disease: Acetic anhydride is a severe eye irritant and may cause tissue damage. Those with pre-existing eye problems may be at increased risk from exposure.

Residues of acetic anhydride are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: solvent, cosolvent.

Residues of acetic anhydride are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals. Use: solvent, cosolvent, stabilizer.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Acetic anhydride is produced, as an intermediate or a final product, by process units covered under this subpart.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV.D.3.b).

Acetic anhydride is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.