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3,5-Xylidin
3,5-XYLIDINE · 3,5-Dimethylbenzenamine · Benzenamine, 3,5-dimethyl- · 3,5-Xylidin · Sincerity-MA · 3,5-Xylidene · 3,5-Xylylamine · 5-AMINO-M-XYLENE
Identifikatoren & physikalische Daten
| CAS No. | 108-69-0 |
|---|---|
| Summenformel | C8H11N |
| Durchschnittliche Molmasse | 121,18 g/mol |
| Monoisotopische Masse | 121,08914935 g/mol |
| SMILES | Cc1cc(C)cc(N)c1 |
| InChIKey | MKARNSWMMBGSHX-UHFFFAOYSA-N |
| PubChem CID | 7949 |
| ChEMBL | CHEMBL1603782 |
| EC No. | 203-607-0 |
| DTXSID | DTXSID8026309 |
| Lokaler Name | 3,5-Xylidin |
Chemische & physikalische Eigenschaften
| XLogP | 2 |
|---|---|
| Polarare Oberfläche (TPSA) | 26 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 9 |
| Formalladung | 0 |
| Komplexität | 80,6 |
| Stoffklassen | Nitrogen Compounds -> Amines, Aromatic |
| SpringerMaterials Properties | 13C nuclear magnetic resonance spectrum |
| Dichte | 0.9706 at 68 °F (NTP, 1992) - Less dense than waterwill float0.9706 @ 20 °C/4 °CRelative density (water = 1): 0.970.972 g/mL at 25 °C(lit.) |
| Color/Form | Oily liquid |
| Löslichkeit | less than 1 mg/mL at 66 °F (NTP, 1992)Sol in ether, carbon tetrachlorideslightly soluble in waterSolubility in water, g/100ml at 20 °C: 0.48<0.1 g/100 mL at 19 ºC |
| Flammpunkt | 200 °F (NTP, 1992)97 °C (206 °F) (Closed cup)93 °C |
| Siedepunkt | 428 to 430 °F at 760 mmHg (NTP, 1992)220.5 °C220 °C104-105 °C14 mm Hg(lit.) |
| Decomposition | WHEN HEATED TO DECOMP, XYLIDINES EMIT HIGHLY TOXIC FUMES. /XYLIDINES/ |
| Schmelzpunkt | 49.6 °F (NTP, 1992)9.8 °C7-9 °C |
| Dampfdichte | Relative vapor density (air = 1): 4.19 |
| Geruchsschwelle | Odor threshold in air= 1.00X10+12 molecules/cc /Xylidines/Low threshold= 0.0240 mg/cu mHigh threshold= 0.0240 mg/cu m. /Xylidine/ |
| Dampfdruck | 0.12 [mmHg]Vapor pressure, kPa at 20 °C: 0.131.3-27hPa at 20-100℃ |
| Brechungsindex | n20/D 1.557(lit.) |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | pK1:4.765(+1) (25°C) |
| Farbe | Clear yellow-brown to brown |
| Merck | 14,10084 |
| Specific Activity | 50-60 mCi/mmol |
| BRN | 507051 |
| Henry-Konstante | 3.9×100 mol/(m3Pa) at 25℃, HSDB (2015) |
| InChI | 1S/C8H11N/c1-6-3-7(2)5-8(9)4-6/h3-5H,9H2,1-2H3 |
| InChIKey | MKARNSWMMBGSHX-UHFFFAOYSA-N |
| SMILES | Cc1cc(C)cc(N)c1 |
| CAS Datenbank | 108-69-0(CAS DataBase Reference) |
| NIST chemische Informationen | Benzenamine, 3,5-dimethyl-(108-69-0) |
| EPA chemische Informationen | 3,5-Dimethylaniline (108-69-0) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301+H311+H331 (68.5%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oralacute toxicity, dermalacute toxicity, inhalation]P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P319, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 162 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H302: Harmful if swallowed [Warning Acute toxicity, oral] |
|---|---|
| Regulatorische Informationen | Chemical: Benzenamine, 3,5-dimethyl-Status: Active Update: 20-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/12529 |
| Weitere Sicherheitsinformationen | IMAP assessments - Xylidines: Human health tier II assessment |
| DOT-Kennzeichnung | Explosive 1.3C Poison |
| Brandgefahren | This chemical is combustible. (NTP, 1992)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 93 °C explosive vapour/air mixtures may be formed. |
| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this compound may include headaches, drowsiness, cyanosis, mental confusion, convulsions, nervous system and blood effects, fatigue, loss of appetite and dizziness. |
| Gefahrenübersicht | Heavy exposure can cause methemoglobinemia and lowering of consciousnessChronic exposure may cause anemiaCan be absorbed through skin[ICSC] Erythrocyte hemolysis, significantly increased methemoglobin levels, and liver and kidney injury observed in sub-chronic oral studies of ratsMay cause irritation, headache, drowsiness, cyanosis, confusion, convulsions, and other nervous system and blood effects[NTP] Toxic by ingestion, inhalation, and skin absorptionProlonged or repeated exposure may cause kidney and liver injury[ECHA REACH Registrations] An irritantToxic by ingestion, inhalation, and skin absorptionMay induce methemoglobinemia[Alfa Aesar MSDS] See Xylidine, mixed isomers.The major hazards encountered in the use and handling of 3,5-xylidine stem from its toxicologic properties. Toxic by all routes (ie, inhalation, ingestion, and dermal absorption), exposure to this oil may occur from its use as a chemical intermediate for the production of dyes. Contact with 3,5-xylidine may cause burns to the skin and eyes. Death is also a possible outcome from exposure. While the OSHA PEL is set at a TWA of 5 ppm, the ACGIH lists xylidine (mixed isomers) on its 1988-1989 Notice of Intended Changes with a proposed TLV of 0.5 ppm, and a designation of "suspected human carcinogen". In activities or situations where over-exposure may occur, wear a self-contained breathing apparatus, and full chemical protective clothing which is specifically recommended by the shipper or manufacturer to prevent skin contact with xylidine. If contact should occur, immediately flush the affected skin or eyes with running water for at least 15 minutes. Remove contaminated clothing and shoes at the site. Do not eat or smoke in xylidine work areas. While xylidine does not ignite easily, it can burn with the production of irritating or poisonous gases. Also, containers may explode violently in the heat of a fire. Fires involving xylidine may be extinguished with dry chemical, CO2, Halon, or standard foam. Water spray if used, should be applied with caution because it may cause frothing. Fight the fire from a maximum distance and dike runoff from fire control water. Xylidine should be stored away from heat, strong oxidizers, and hypochlorite bleaches. Shipping regulations and other DOT regulatory requirements should be consulted before transport. If xylidine should spill, dike far ahead, then take up with sand or other noncombustible absorbent and place into containers for later disposal. Incineration is a possible form of disposal for xylidine. Before implementing land disposal of waste 3,5-xylidine, consult with environmental regulatory agencies for guidance. |
| Reaktive Gruppe | Amines, Aromatic |
| EG-Einstufung | Symbol: T, NR: 23/24/25-33-51/53S: (1/2)-28-36/37-45-61 |
| UN-Einstufung | UN Hazard Class: 6.1UN Pack Group: II |
| OSHA Standards | Permissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 5 ppm (25 mg/cu m). Skin Designation. /Xylidine/Vacated 1989 OSHA PEL TWA 2 ppm (10 mg/cu m), skin designation, is still enforced in some states. /Xylidine/ |
| Reactivity Profile | 3,5-XYLIDINE ignites on contact with fuming nitric acid (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. |
| Chemical Dangers | Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides. Reacts violently with strong oxidants. Reacts with hypochlorites. This produces explosive chloroamines. Reacts with acids, acid anhydrides, acid chlorides and halogens. Attacks plastic and rubber. |
| Brandbekämpfung | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)Use water spray, carbon dioxide, foam, powder. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .Rinse with plenty of water for several minutes (remove contact lenses if easily possible).Rinse mouth. Refer for medical attention . |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Sichere Lagerung | Separated from strong oxidants, acids, acid anhydrides, acid chlorides, hypochlorites, halogens and food and feedstuffs. Well closed. Store in an area without drain or sewer access. |
| Expositionsschutz und Persönliche Schutzausrüstung | Biological Exposure Indices (BEI) [ACGIH] - Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
| Brandbekämpfungsverfahren | USE WATER SPRAY, DRY CHEMICAL, FOAM, OR CO2WEAR FULL PROTECTIVE CLOTHING. /XYLIDINES/If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Xylidines/ |
| Reinigungsverfahren | Environmental considerations - land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. /Xylidines/Environmental considerations - water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses. /Xylidines/ |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Disposal methods: incineration. A). Dissolve in such combustible solvent as alcohols, benzene, etc. Spray solvent into the furnace with afterburner and scrubber. B). Pour into a mixture of sand and soda ash (9:1). After mixing, put into a paper carton stuffed full with packing paper to serve as fuel. Burn in the furnace. /Xylidines/ |
| Verschüttetes entsorgen | Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Non-impervious clothing which becomes contaminated with xylidine should be t removed immediately and not reworn until the xylidine is removed from the clothing. /Xylidines/Eating and smoking should not be permitted in areas where liquid xylidine is handled, processed, or stored. /Xylidines/Employees who handle liquid xylidine should wash their hands thoroughly with soap or mild detergent and water before eating, smoking, or using toilet facilities. /Xylidines/For more Preventive Measures (Complete) data for 3,5-XYLIDINE (7 total), please visit the HSDB record page. |
| Isolation and Evacuation | Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]: |
| Körperbelastung | Seven of forty-six human adipose tissue samples (positive samples all within the 45 yr and above age bracket4 positive samples collected from the north-central region, 1 sample from the south and 2 samples from the west) contained 3,5-xylidine at unreported concentrations(1). |
| Umweltverhalten | TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 120(SRC), determined from a structure estimation method(2), indicates that 3,5-xylidine will have high mobility in soil(SRC). However, anilines are expected to bind stongly to humus or soil organic matter in soils due to the high reactivity of the aromatic amino group(3,4), suggesting that mobility may be much lower in some soils(SRC). Volatilization of 3,5-xylidine may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 2.5X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(5). Based on limited aqueous screening study data, 3,5-xylidine may rapidly biodegrade under aerobic conditions in soil(SRC)3,5-xylidine was degraded by 53% in 6 hours using an activated sludge inoculum(6).AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 120(SRC), determined from a structure estimation method(2), indicates that 3,5-xylidine should not adsorb to suspended solids and sediment in water(SRC). However, aromatic amine groups are recognized as having a strong affinity to organic carbon, suggesting that this compound may bind strongly to suspended organic material in water(3,4). 3,5-Xylidine may volatilize from water surfaces(1,SRC) based on an estimated Henry's Law constant of 2.5X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). Estimated volatilization half-lives for a model river and model lake are 16 and 120 days, respectively(1,SRC), although adsorption onto organic material may attenuate this process(SRC). According to a classification scheme(7), an estimated BCF value of 26(1,SRC), from an estimated log Kow of 2.2(6,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Based on limited aqueous screening study data, 3,5-xylidine may rapidly biodegrade under aerobic conditions in water(SRC)3,5-xylidine was degraded by 53% in 6 hours using an activated sludge inoculum(8). As a class, aromatic amines react relatively rapidly in sunlit natural water via reaction with photochemically-produced hydroxyl radicals and peroxy radicals(9)typical half-lives for peroxy and hydroxy radical reactions are on the order of 19 and 30 sunlight hours, respectively(9).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 3,5-xylidine, which has an estimated vapor pressure of 0.13 mm Hg at 25 °C(2,SRC), should exist solely as a vapor in the ambient atmosphere. Vapor-phase 3,5-xylidine may be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be about 2 hours(3,SRC). |
| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Expositionspfade | The substance can be absorbed into the body in hazardous amounts by inhalation, through the skin and by ingestion. |
| Signs and Symptoms | Dizziness. Drowsiness. Headache. Nausea.MAY BE ABSORBED! See Ingestion.Blue lips, fingernails and skin. Dizziness. Drowsiness. Headache. Nausea. Unconsciousness. |
| ICSC Environmental Data | This substance may be hazardous to the environment. Special attention should be given to aquatic organisms. |
| Medical Surveillance | Initial medical examination: A complete history & physical examination. The purpose is to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Exam of the blood, lung, liver, kidneys, and cardiovascular system should be stressed. ... Periodic medical exam ... should be repeated on an annual basis. /Xylidine/ |
| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indices(1), the Koc for 3,5-xylidine can be estimated to be about 120(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that 3,5-xylidine has high mobility in soil(SRC). However, anilines are expected to bind stongly to humus or soil organic matter in soils due to the high reactivity of the aromatic amino group(3,4). Low adsorption is observed at a neutral pH with pure clay minerals or soils for substituted anilines(4). |
| Artificial Pollution Sources | 3,5-Xylidine's production and subsequent use in the manufacture of azo dyes(1) may result in its release to the environment through various waste streams(SRC). |
| Environmental Biodegradation | 3,5-Xylidine, initially present at 20 mg/l, was 53% degraded in 6 hours using an activated sludge inoculum under aerobic conditions(1). E. coli converted 3,5-xylidine to the corresponding (phenylazo)naphthol in the presence of nitrate with this reaction proceeding within 24 hours(2). |
| Environmental Bioconcentration | An estimated BCF value of 26 was calculated for 3,5-xylidine(SRC), using an estimated log Kow of 2.2(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). |
| Volatilization from Water/Soil | The Henry's Law constant for 3,5-xylidine is estimated as 2.5X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that 3,5-xylidine will volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 16 days(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 120 days(2,SRC). Adsorption to organic material may attenuate this process(SRC). The Henry's Law constant value for 3,5-xylidine(1,SRC) indicates that volatilization from moist soil surfaces may occur(SRC). |
| F | 8 |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 1711 6.1/PG 2 |
| Zollcode | 29214990 |
| RTECS-Nr. | ZE9625000 |
| R-Sätze (R) | 23/24/25-33-51/53 |
| Gefahrensymbole | T,N |
| hazard_note | Toxic |
| Sicherheitshinweise (S) | 28-36/37-45-61-28A |
| Gefahrenklasse | 6.1Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralAquatic Chronic 2STOT RE 2 |
| Verpackungsgruppe | II |
| Lagerklasse | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| Gefahrstoffdaten | 108-69-0(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
3,5-Dimethylaniline is the reagent commonly useful in the manufacture of dyes. It undergoes polymerization in the presence of cerium(IV) sulfate as an oxidant. This compound was also employed to produce chiral packing materials for high performance liquid chromatography.