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HCID 7996Erstellt: 27. Oktober 2026

2-Isopropoxy-ethanol

ISOPROPYL GLYCOL · Ucar AC · Ethanol, 2-(1-methylethoxy)- · Ethylene glycol monoisopropyl · ETHYLENE GLYCOL MONOISOPROPYL ETHER · isopropoxyethanol · 2-(1-methylethoxy)-Ethanol · ucarac

https://huagongshe.com/de/chemical/7996

Molekülstruktur von 2-Isopropoxy-ethanol

Identifikatoren & physikalische Daten

CAS No.109-59-1
SummenformelC5H12O2
Durchschnittliche Molmasse104,15 g/mol
Monoisotopische Masse104,08372962 g/mol
SMILESCC(C)OCCO
InChIKeyHCGFUIQPSOCUHI-UHFFFAOYSA-N
PubChem CID7996
ChEMBLCHEMBL3187409
EC No.203-685-6
DTXSIDDTXSID4047466
Lokaler Name2-Isopropoxy-ethanol

Chemische & physikalische Eigenschaften

XLogP0,1
Polarare Oberfläche (TPSA)29,5
H-Brücken-Donoren1
H-Brücken-Akzeptoren2
Frei drehbare Bindungen3
Schwere Atome7
Formalladung0
Komplexität35,1
StoffklassenFlammable agents - 2nd degree
SolventsSolvents -> Glycol Ethers (E Series)
SpringerMaterials PropertiesBoiling point
LogP (Verteilungskoeffizient)0.05
GeruchMILD ETHEREAL ODORMild, ethereal odor.
GeschmackBITTER TASTE
Dichte0.91 (USCG, 1999) - Less dense than waterwill float0.9030 @ 20 °C/4 °CRelative density (water = 1): 0.903 (20 °C)0.903 g/mL at 25 °C(lit.)
Color/FormCOLORLESS LIQUIDColorless liquid.
LöslichkeitMiscible (NIOSH, 2024)SOL IN ALL PROP IN WATER, ALC, ETHERSOL IN ACETONESolubility in water, g/100ml at 25 °C: 100>100g/l solubleIt is soluble in water.
Flammpunkt91.4 °F (USCG, 1999)33 °C92 °F (33 °C) OC44 °C c.c.(oc) 92 °F114 °F
Siedepunkt285.8 °F at 760 mmHg (USCG, 1999)144 °C @ 743 MM HGat 99kPa: 139.5-144.5 °C283 °F42-44 °C13 mm Hg(lit.)
Schmelzpunkt-60 °C
Dampfdruck5.99 hPa (25 °C)
Brechungsindexn20/D 1.41(lit.)
LagerbedingungenStore below +30°C.
pKa (Säurekonstante)14.47±0.10(Predicted)
AggregatzustandLiquid
FarbeColorless to Almost colorless
Explosionsgrenze1.6-13.0%(V)
BRN1732184
Henry-Konstante4.8×100 mol/(m3Pa) at 25℃, Johanson and Dynésius (1988)
StabilitätStable. Incompatible with strong oxidizing agents. Combustible.
InChI1S/C5H12O2/c1-5(2)7-4-3-6/h5-6H,3-4H2,1-2H3
InChIKeyHCGFUIQPSOCUHI-UHFFFAOYSA-N
SMILESCC(C)OCCO
LogP (Verteilungskoeffizient)0.43 at 20℃
CAS Datenbank109-59-1(CAS DataBase Reference)
EPA chemische InformationenIsopropoxyethanol (109-59-1)

Sicherheit & Vorschriften

GHS-EinstufungWarningH312: Harmful in contact with skin [Warning Acute toxicity, dermal]P261, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P317, P321, P337+P317, P362+P364, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.2% (1 of 648) of reports.H226 (41.7%): Flammable liquid and vapor [Warning Flammable liquids]
Regulatorische InformationenChemical: Ethanol, 2-(1-methylethoxy)-Status: Active Update: 07-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/12659Ethanol, 2-(1-methylethoxy)-: HSNO Approval: HSR001158 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
Weitere SicherheitsinformationenIMAP assessments - 2-(1-methylethoxy)ethanol and its acetate: Human health tier II assessment
DOT-KennzeichnungPoison Flammable Liquid
BrandgefahrenSpecial Hazards of Combustion Products: Emits toxic fumes when heated upon decomposition. (USCG, 1999)Flammable. Above 44 °C explosive vapour/air mixtures may be formed.
BrandpotenzialMODERATECAN REACT WITH OXIDIZING MATERIALS
GesundheitsgefahrenMay be harmful by inhalation, ingestion or skin absorption. May cause skin and eye irritation. (USCG, 1999)
GefahrenübersichtOsmotic fragility of rat erythrocytes markedly increased at exposures of 200 ppm[ACGIH] Inhalation of high concentrations can cause CNS depression[HSDB] May cause skin and eye irritation[CAMEO] See Glycol ethers.
Reaktive GruppeAlcohols and Polyols
EG-EinstufungSymbol: XnR: 20/21-36

Anwendungen & Verwendung

Verwenden

2-Isopropoxyethanol was used to study the products of the gas-phase reactions of OH radical with n-butyl methyl ether and 2-isopropoxyethanol in the presence of NO. 2-Isopropoxyethanol was used to develop methodology for evaluating electromagnetic sensor performance in nonrelaxing and nonconducting (e.g., sandy soil) media

S: (2)-24/25
UN-EinstufungUN Hazard Class: 3UN Pack Group: III
Reactivity AlertsHighly Flammable
Reactivity ProfileETHYLENE GLYCOL ISOPROPYL ETHER acts both as an alcohol and ether. May react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.
BrandbekämpfungFire Extinguishing Agents: Water, carbon dioxide, dry chemical, alcohol foam. (USCG, 1999)Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
Erste-Hilfe-MaßnahmenFresh air, rest.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink.
Erste HilfeExcerpt from NIOSH Pocket Guide for 2-Isopropoxyethanol:(General first aid procedures)
Sichere LagerungCool. Fireproof. Separated from strong oxidants.
Expositionsschutz und Persönliche Schutzausrüstung10.0 [ppm]
Brandbekämpfungsverfahren"ALCOHOL" FOAM. WATER MAY BE INEFFECTIVE
LagerbedingungenSEE ETHERS. ETHERS SHOULD NOT BE STORED NEAR POWERFUL OXIDIZERS OR IN AREAS OF HIGH FIRE HAZARD. THEY SHOULD BE KEPT COOL AND THE CONTAINERS ELECTRICALLY GROUNDED TO AVOID SPARKS. /ETHERS/
Freisetung ohne BrandExcerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
Verschüttetes entsorgenPersonal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible.
Preventive MeasuresSEE ETHERS. ONLY ELECTRICAL EQUIPMENT OF EXPLOSION-PROOF TYPE (GROUP C CLASSIFICATION) IS PERMITTED TO BE OPERATED IN ETHER AREAS. /ETHERS/...ADVISABLE TO PROTECT PERSONNEL BY ENCLOSING PROCESS OR PROVIDING LOCAL EXHAUST VENTILATION. MAIN HAZARD...THAT OF INGESTION, CAN USUALLY BE PREVENTED BY KEEPING /CHEM/ IN PROPERLY LABELLED CONTAINERS. /GLYCOL & DERIV/The worker should immediately wash the skin when it becomes contaminated.Work clothing that becomes wet should be immediately removed due to its flammability hazard.
Isolation and EvacuationExcerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
Eye PreventionWear safety goggles.
ZielorganeEyes, skin, respiratory system, blood
Unerwünschte WirkungenNeurotoxin - Acute solvent syndrome
ExpositionspfadeThe substance can be absorbed into the body by inhalation of its vapour and through the skin.inhalation, skin absorption, ingestion, skin and/or eye contact
Signs and SymptomsCough.MAY BE ABSORBED! Redness.Redness. Pain.Nausea.In Animals: irritation eyes, skinhematuria (blood in the urine), anemia, pulmonary edema
Human Toxicity ExcerptsSYMPTOMATOLOGY: 1. CENTRAL NERVOUS DEPRESSION CHARACTERIZED BY TRANSIENT EXHILARATION, DRUNKENNESS, ATAXIA, VERTIGO PROGRESSING TO STUPOR &...COMA, WITH OR WITHOUT TRANSIENT PERIOD OF CONVULSIONS. DEATH FROM RESP ARREST OR...CARDIOVASCULAR COLLAPSE... /ETHYLENE GLYCOL/SYMPTOMATOLOGY: 2. NAUSEA, VOMITING, ABDOMINAL PAIN, DEHYDRATION, WEAKNESS, MUSCLE TENDERNESS. 3. HYPERPNEA MAY INDICATE EITHER SEVERE METABOLIC ACIDOSIS OR PULMONARY EDEMA. 4. ...CARPOPEDAL SPASM OR OTHER SIGNS OF HYPOCALCEMIC TETANY. /ETHYLENE GLYCOL/SYMPTOMATOLOGY: 5. LUMBAR PAIN, ALBUMINURIA, HEMATURIA, OLIGURIA PROGRESSING TO ANURIA. 6. ACUTE RENAL FAILURE WITH UREMIA, PERIPHERAL EDEMA, ASCITES, PULMONARY EDEMA, DROWSINESS, CYANOSIS, COMA, & DEATH IN 7 TO 10 DAYS. /ETHYLENE GLYCOL/SEE GLYCOLS. THERE IS SOME EVIDENCE THAT THE GLYCOL ETHERS ARE MORE TOXIC THAN OTHER MEMBERS OF THE GLYCOL GROUP. /GLYCOLS/For more Human Toxicity Excerpts (Complete) data for ISOPROPOXYETHANOL (7 total), please visit the HSDB record page.
Non-Human Toxicity ExcerptsTHE MATERIAL IS APPRECIABLY IRRITATING TO EYES OF RABBITS CAUSING INJURY TO CONJUNCTIVAL MEMBRANES, CORNEA, &...SOME IRITIS. HEALING APPEARED TO BE COMPLETE WITHIN A WEEK.THE MATERIAL IS NOT APPRECIABLE IRRITATING TO THE SKIN UNDER ORDINARY CONDITIONS OF EXPOSURE, BUT IF IT IS CONFINED FOR PROLONGED PERIODS, IT MAY CAUSE APPRECIABLE IRRITATION, EVEN A BURN. ...THE MATERIAL MAY READILY BE ABSORBED THROUGH THE INTACT SKIN IN LETHAL AMT.FOUR/FOUR RATS DIED DURING 7 HR OF EXPOSURE TO VAPORS AT ESSENTIALLY SATURATED CONCN, AT 100 °C & COOLED TO ROOM TEMP. AFTER 3 HR, BLOOD APPEARED IN URINE1 RAT AUTOPSIED AFTER EXPOSURE HAD BLACK & SEVERELY ENLARGED KIDNEYS. /FROM TABLE/TWO/THREE RATS DIED DURING 4 HR OF EXPOSURE TO VAPORS AT ESSENTIALLY SATURATED CONCN. BLOODY URINE WAS PASSED IMMEDIATELY AFTER EXPOSURE. THERE WAS EXCESS URINE. THREE DAYS AFTER EXPOSURE THE KIDNEYS WERE SEVERELY NECROTIC AND DARK IN COLOR. /FROM TABLE/For more Non-Human Toxicity Excerpts (Complete) data for ISOPROPOXYETHANOL (10 total), please visit the HSDB record page.
Probable Routes of Human ExposureNO REPORTS OF ADVERSE EFFECTS FROM THE HANDLING OR USE OF ETHYLENE GLYCOL MONOISOPROPYL ETHER HAVE BEEN MADE. ...THIS MAY BE BECAUSE OF ITS LIMITED USE TO DATE....NO DATA AVAILABLE THAT WOULD ALLOW THE ESTABLISHMENT OF A HYGIENIC STANDARD FOR REPEATED EXPOSURE TO VAPORS. IN VIEW OF HIGH TOXICITY.../TO/ ANIMALS, IT WOULD SEEM...PRUDENT TO TAKE PARTICULAR CARE TO PREVENT ALL POSSIBLE EXPOSURE OF HUMAN BEINGS TO THIS MATERIAL...
Toxicity DataLC50 (rat) = 3,100 mg/m3/4h
Wassergefährdungsklasse (WGK)1
TSCA-Inventar-StatusTSCA listed
UN-TransportnummerUN 2929 6.1/PG 2
Zollcode2909 44 00
RTECS-Nr.KL5075000
R-Sätze (R)20/21-36
ToxizitätLD50 orally in Rabbit: 5111 mg/kg LD50 dermal Rabbit 1445 mg/kg
GefahrensymboleXn
Sicherheitshinweise (S)24/25
Gefahrenklasse3Acute Tox. 4 DermalAcute Tox. 4 InhalationEye Irrit. 2Flam. Liq. 3Skin Irrit. 2
VerpackungsgruppeIII
Lagerklasse3 - Flammable liquids
Gefahrstoffdaten109-59-1(Hazardous Substances Data)
Selbstentzündungstemperatur240 °C