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Ethylenglykolmonoethylether
Ethoxyethanol · ETHYL GLYCOL · ETHYLENE GLYCOL MONOETHYL ETHER · ETHYL CELLOSOLVE · CELLOSOLVE · Ethanol, 2-ethoxy- · Glycol monoethyl ether · EGEE
Identifikatoren & physikalische Daten
| CAS No. | 110-80-5 |
|---|---|
| Summenformel | C4H10O2 |
| Durchschnittliche Molmasse | 90,12 g/mol |
| Monoisotopische Masse | 90,06807956 g/mol |
| SMILES | CCOCCO |
| InChIKey | ZNQVEEAIQZEUHB-UHFFFAOYSA-N |
| PubChem CID | 8076 |
| ChEMBL | CHEMBL119596 |
| ChEBI | CHEBI:46788 |
| EC No. | 203-804-1 |
| DTXSID | DTXSID7024087 |
| Lokaler Name | Ethylenglykolmonoethylether |
Chemische & physikalische Eigenschaften
| XLogP | -0,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 29,5 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 6 |
| Formalladung | 0 |
| Komplexität | 21 |
| LogP (Verteilungskoeffizient) | -0.32log Kow = -0.32-0.540 |
| Geruch | Sweet, pleasant, ether-like odorMild, agreeable odorPractically odorless |
| Geschmack | SLIGHTLY BITTER |
| Dichte | 0.931 at 68 °F (USCG, 1999) - Less dense than waterwill float0.9253 g/cu cm at 25 °CBulk density: 7.74 lb at 20 °Cpour point: less than 37.7 °CRelative density (water = 1): 0.930.9253 @25 °C0.93 g/mL at 25 °C(lit.) |
| Viscosity | 1.84 centipoise at 25 °C |
| Color/Form | Colorless liquid |
| Löslichkeit | greater than or equal to 100 mg/mL at 64 °F (NTP, 1992)1000000Miscible with waterVery soluble in acetone, ethyl ether, ethanolMiscible with hydrocarbonsMiscible in all proportions of acetone, benzene, carbon tetrachloride, ethyl ether, methanol, and water.water: miscible |
| Flammpunkt | 105 °F (NTP, 1992)43 °C110 °F (43 °C) (closed cup)120 °F (49 °C) open cup202 °F44 °C c.c.107.6 °F |
| Siedepunkt | 275 °F at 760 mmHg (NTP, 1992)135135.7 °C135.00 °C. @ 760.00 mm Hg135 °C135 °C(lit.) |
| Decomposition | Hazardous decomposition products formed under fire conditions. - Carbon oxides |
| Schmelzpunkt | -94 °F (NTP, 1992)-70-70 °C-100 °C |
| Dampfdichte | 3.1 (NTP, 1992) - Heavier than airwill sink (Relative to Air)Relative vapor density (air = 1): 3.13.1 (vs air) |
| Dampfdruck | 3.8 mm Hg ( 20 °C) |
| Brechungsindex | n20/D 1.407(lit.) |
| Lagerbedingungen | Store below +30°C. |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | 14.44±0.10(Predicted) |
| Farbe | Clear, colorless |
| Geruch | Sweetishmild, pleasant, ethereal. |
| pH | 7 (20°C) |
| Geruchsschwelle | 0.58ppm |
| Explosionsgrenze | 1.8-15.7%(V) |
| Spezifische Wärmekapazität | Cp(liquid): 2.34 J/(g·K), at 25℃ |
| Merck | 14,3750 |
| BRN | 1098271 |
| Henry-Konstante | 8.9×100 mol/(m3Pa) at 25℃, Johanson and Dynésius (1988) |
| Dielektrizitätskonstante | 29.6(24℃) |
| Stabilität | Stable. Readily forms explosive mixtures with air - note the wide explosion range. Vapour may travel considerable distance to a source of ignition. Flammable. Incompatible with strong acids, strong bases, strong oxidizing agents, aluminium, alkalies. |
| Kosmetik-Inhaltsstoffe Funktionen | SOLVENTVISCOSITY CONTROLLING |
| InChI | 1S/C4H10O2/c1-2-6-4-3-5/h5H,2-4H2,1H3 |
| InChIKey | ZNQVEEAIQZEUHB-UHFFFAOYSA-N |
| SMILES | CCOCCO |
| LogP (Verteilungskoeffizient) | 0.32 at 20℃ |
| Oberflächenspannung | 28.6mN/m at 20°C |
| CAS Datenbank | 110-80-5(CAS DataBase Reference) |
| NIST chemische Informationen | Ethanol, 2-ethoxy-(110-80-5) |
| EPA chemische Informationen | 2-Ethoxyethanol (110-80-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH226: Flammable liquid and vapor [Warning Flammable liquids]H302: Harmful if swallowed [Warning Acute toxicity, oral]H331: Toxic if inhaled [Danger Acute toxicity, inhalation]H360FD: May damage fertilityMay damage the unborn child [Danger Reproductive toxicity]P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P316, P318, P321, P330, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) |
|---|---|
| Regulatorische Informationen | Chemical: Ethanol, 2-ethoxy-Hazard Traits - Developmental ToxicityHematotoxicityReproductive ToxicityAuthoritative List - CA TACsEC Annex VI CMRs - Cat. 1BOEHHA RELsProp 65Report - regardless of intended function of ingredient in the productEthanol, 2-ethoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2-ethoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)S - indicates a substance that is identified in a final Significant New Use Rule.Status: Active Update: 12-08-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/14915Substance: 2-ethoxyethanolEC: 203-804-1Date of inclusion: >15-Dec-2010Reason for inclusion: Toxic for reproduction (Article 57c) |
| Weitere Sicherheitsinformationen | IMAP assessments - Ethanol, 2-ethoxy-: Environment tier I assessmentIMAP assessments - Alkoxyethanols (C1-C2) and their acetates: Human health tier II assessment |
| DOT-Kennzeichnung | Flammable Liquid |
| Brandgefahren | Special Hazards of Combustion Products: Toxic gases, such as carbon monoxide, may be produced in fire. (USCG, 1999)· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)· Vapors may form explosive mixtures with air.· Vapors may travel to source of ignition and flash back.· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).· Vapor explosion hazard indoors, outdoors or in sewers.· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.· Runoff to sewer may create fire or explosion hazard.· Containers may explode when heated.· Many liquids will float on water.Flammable. Above 44 °C explosive vapour/air mixtures may be formed. |
| Brandpotenzial | Flammable in the presence of a source of ignition when the temperature is above the flash point.Flammable. |
| Gesundheitsgefahren | Some eye irritation. Inhalation of vapors causes irritation of nose. (USCG, 1999)· Inhalation or contact with material may irritate or burn skin and eyes.· Fire may produce irritating, corrosive and/or toxic gases.· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.· Runoff from fire control or dilution water may cause environmental contamination. |
| Gefahrenübersicht | Changes in the lungs, kidneys, liver, and spleen are seen in mice after 7-hour lethal concentration studies. For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] Labeled as May impair fertility and May cause harm to the unborn child by EU regulations[Glycol Ethers Online] See Glycol ethers. |
| DOT-Nummer und Handbuch | 1171 127 |
| FDA-Anforderungen | The following substance may be safely used as diluents in color additive mixtures for food use exempt from certification, subject to the condition that each straight color in the mixture has been exempted from certification or, if not so exempted, is from a batch that has previously been certified and has not changed in composition since certification. If a specification for a particular diluent is not set forth in this part 73, the material shall be of a purity consistent with its intended use. Ethylene glycol monoether ether is used as a diluent in color additive mixtures for marking food-(i) Inks for marking food supplements in tablet form, gum, and confectionery. Restriction: No residue.Ethylene glycol monoethyl ether is an indirect food additive for use only as a component of adhesives. |
| Reaktive Gruppe | Alcohols and PolyolsEthers |
| UN-Einstufung | UN Hazard Class: 3UN Pack Group: III |
| Special Reports | Johanson GAspects of biological monitoring of exposure to glycol ethersToxicol Lett 43 (1-3): 5-21 (1988)Paustenback DJ, Assessment of the Developmental Risks Resulting from Occupational Exposure to Select Glycol Ethers within the Semi-conductor IndustryJ Toxicol Environ Health 23 (1): 29-75 (1988)Kay GF et alSolvent Toxicology, Annual Review of Pharmacology and Toxicology 27: 399-427 (1987).Miller RRMetabolism and Disposition of Glycol EthersDrug Metab Rev 18 (1): (1987).For more Special Reports (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER (6 total), please visit the HSDB record page. |
| Brandbekämpfung | Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used. CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.).SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzlesif this is impossible, withdraw from area and let fire burn. (ERG, 2024)Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . |
| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep unauthorized personnel away.· Stay upwind, uphill and/or upstream.· Ventilate closed spaces before entering, but only if properly trained and equipped.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.· All equipment used when handling the product must be grounded.· Do not touch or walk through spilled material.· Stop leak if you can do it without risk.· Prevent entry into waterways, sewers, basements or confined areas.· A vapor-suppressing foam may be used to reduce vapors.· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.· Use clean, non-sparking tools to collect absorbed material.Large Spill· Dike far ahead of liquid spill for later disposal.· Water spray may reduce vapor, but may not prevent ignition in closed spaces. |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)General First Aid:· Call 911 or emergency medical service.· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.· Move victim to fresh air if it can be done safely.· Administer oxygen if breathing is difficult.· If victim is not breathing:-- DO NOT perform mouth-to-mouth resuscitationthe victim may have ingested or inhaled the substance.-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.· Remove and isolate contaminated clothing and shoes.· For minor skin contact, avoid spreading material on unaffected skin.· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.· For severe burns, immediate medical attention is required.· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.· Keep victim calm and warm.· Keep victim under observation.· For further assistance, contact your local Poison Control Center.· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.Specific First Aid:· Wash skin with soap and water.(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.Breathing: Respiratory supportSwallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. |
| Sichere Lagerung | Fireproof. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Cool. |
| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA).· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.Biological Exposure Indices (BEI) [ACGIH] - 2-Ethoxyacetic acid in urine = 40 mg/g creatinineend of shift at end of workweek2.0 [ppm], sum of the concentrations of CAS 110-80-5 and its acetate in air[German Research Foundation (DFG)] |
| Brandbekämpfungsverfahren | If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.Use water spray, powder, alcohol-resistant foam, carbon dioxide.In case of fire: keep drums, etc., cool by spraying with water.To fight fire, use alcohol foam, dry chemical.For more Fire Fighting Procedures (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER (6 total), please visit the HSDB record page. |
| Lagerbedingungen | Conditions for safe storage: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Fireproof. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Cool. |
| Reinigungsverfahren | Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.Personal precautions: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.SPILLAGE DISPOSAL: Remove all ignition sources. Personal protection: filter respirator for organic gases and vapors adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Wash away remainder with plenty of water. |
| Freisetung ohne Brand | Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024) |
| Entsorgungsverfahren | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers U359 and F005 must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Ethylene glycol monoethyl ether is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. Concentrated waste containing no peroxides, discharge liquid at a controlled rate near a pilot flame. Concentrated containing peroxidesperforation of a container of the waste from a safe distance followed by open burning.Spray into furnace. Incineration will become easier by mixing with a more flammable solvent. Recommendable method: Incineration.For more Disposal Methods (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER (7 total), please visit the HSDB record page. |
| Verschüttetes entsorgen | Remove all ignition sources. Personal protection: protective clothing, protective gloves and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Wash away remainder with plenty of water. |
| Wechselwirkungen | 2-ethoxyethanol, induced complete embryomortality in pregnant rats exposed to three times the current Federal permissible exposure limit (PEL). Following exposure to ethoxyethanol at a concentration only one-half the current PEL, the offspring evidenced behavioral and neurochemical deviations from controls. Subsequent studies found that ingestion of ethanol with concomitant inhalation of ethoxyethanol vapors early in pregnancy appeared to reduce the number of both behavioral and neurochemical deviations found for ethoxyethanol. In contrast, the concomitant exposure to ethanol and ethoxyethanol later in gestation potentiated the behavioral and neurochemical effects of ethoxyethanol. This research indicates that the industrial solvent 2-ethoxyethanol presents an occupational reproductive hazard and raises the issue of the importance of an interaction of social habits with occupational exposure to such hazards. The results would suggest that occupational physicians should advise pregnant workers in the chemical industry of the adverse effects of ethanol during pregnancy and of the possible interactions with other chemicals and should encourage them to be especially cautious with ethanol consumption since they may be at greater risk.Behavioral and neurochemical deviations in the offspring of rats exposed to 100 ppm ethoxyethanol during gestation have been reported previously. Since this compound is likely metabolized in the same manner as ethanol, the present study investigated the interactive effects of ethanol and ethoxyethanol on prenatal development. Groups of 15-20 pregnant Sprague-Dawley rats were given 10% ethanol in the drinking water with or without concomitant inhalation exposure to 100 ppm ethoxyethanol during gestation days 7-13 or 14-20. Another group was exposed to 200 ppm ethoxyethanol on gestation days 7-13, and sham-exposed controls were included for both gestation periods. Ethanol alone on days 14-20 and 200 ppm ethoxyethanol reduced overall weight gain during pregnancy. As in the previous research, pregnancy duration was extended in the groups given ethoxyethanol, but not in groups given ethanol alone. Neuromotor ability, as assessed by an ascent test and by a rotorod, was reduced by 200 ppm ethoxyethanol and by ethanol alone on gestation days 7-13. The group given ethanol plus ethoxyethanol on days 14-20 spent significantly longer in the start area of an open field, and this group as well as that given 200 ppm ethoxyethanol were less active than controls in the open field and in the shuttle box. When compared with previous research, it appears that ethanol early in gestation may reduce the effects, but later in gestation may enhance the effects of prenatal ethoxyethanol.Repeated exposure of workers to /2-Methoxyethanol/ (2-ME) and /2-Ethoxyethanol/ (2-EE), in addition to other solvents, resulted in anaemia, leucopenia, general weakness, and ataxia.Endocrine disrupting chemicals cause reproductive dysfunction by interacting with intricate regulation and cellular processes involve in spermatogenesis. This study investigated the probable mechanism of action of ethylene glycol monoethyl ether (EGEE) as an antiandrogenic compound as well as the effects of kolaviron upon co-administration with EGEE in rats. Adult male rats were exposed to EGEE (200 mg/kg bw) separately or in combination with either kolaviron [100 (KV1) and 200 (KV2) mg/kg bw] or vitamin E (50 mg/kg bw) for 14 days. Western blot analysis revealed that the administration of EGEE adversely affected steroidogenesis in experimental rats by decreasing the expression of steroid acute regulatory (StAR) protein and androgen-binding protein (ABP). EGEE significantly decreased the activities of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) but markedly increased sialic acid concentration in rat testes. EGEE-treated rats showed significant decreases in plasma levels of luteinizing hormone (31%), testosterone (57.1%), prolactin (80.9%), triiodothyronine (65.3%) and thyroxine (41.4%), whereas follicle-stimulating hormone was significantly elevated by 76.9% compared to the control. However, co-administration of kolaviron or vitamin E significantly reversed the EGEE-induced steroidogenic dysfunction in rats. This study suggests that kolaviron may prove promising as a chemoprotective agent against endocrine pathology resulting from EGEE exposure. |
| Zielorgane | HematologicReproductiveEyes, respiratory system, blood, kidneys, liver, reproductive system, hematopoietic system |
| Ökotoxizitätswerte | LC50Species: Lepomis macrochirus (Bluegill)Concentration: >10000 mg/L for 96hr /Conditions of bioassay not specified in source examined/Species: Artemia salina (brine shrimp)Concentration: 4000 mg/L /Conditions of bioassay not specified in source examined/Species: Poecilia reticulata (guppy)Concentration: 16400 mg/L for 7 days /Conditions of bioassay not specified in source examined/Conditions: saltwater, static, 24.5 °C, >10000 mg/L for 24 hrFor more Ecotoxicity Values (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER (10 total), please visit the HSDB record page. |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a log Kow of -0.32(2) and a regression-derived equation(3), indicates that ethylene glycol monoethyl ether is expected to have very high mobility in soil(SRC). Volatilization of ethylene glycol monoethyl ether from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 4.7X10-7 atm-cu m/mole(4). Ethylene glycol monoethyl ether is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 5.31 mm Hg at 25 °C(5). Utilizing the Japanese MITI test, 76% of the Theoretical BOD was reached in 2 weeks(6) indicating that biodegradation is an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a log Kow of -0.32(2) and a regression-derived equation(3), indicates that ethylene glycol monoethyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 4.7X10-7 atm-cu m/mole(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 74 and 540 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 76% of the Theoretical BOD was reached in 2 weeks(7) indicating that biodegradation is an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol monoethyl ether, which has a vapor pressure of 5.31 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol monoethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 22 hrs(SRC), calculated from its rate constant of 1.54X10-11 cu cm/molecule-sec at 25 °C(3). Ethylene glycol monoethyl ether does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
| Lebensmitteluntersuchungswerte | Ethylene glycol monoethyl ether has been qualitatively detected as a volatile flavor component in fried bacon(1), beef(2), and pork(2). |
| Unerwünschte Wirkungen | Neurotoxin - Acute solvent syndromeOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Aplastic anemia - The presence of increased methemoglobin in the bloodthe compound is classified as primary toxic effect.Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment. |
| Expositionspfade | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| Toxizitätsübersicht | On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Ethoxyethanol and Ethoxyethanol Acetate are unsafe for use in cosmetic products.The ingredient is unsafe for use in cosmeticsIDENTIFICATION AND USE: Ethylene Glycol Monoethyl ether (EGEE) is a colorless liquid with mild, agreeable odor. It is used as a solvent for nitrocellulose, lacquers and dopesin varnish removers, cleansing solutions, dye bathsfinishing leather with water pigments and dye solutionsincreasing stability of emulsions. HUMAN EXPOSURE AND TOXICITY: Short-term exposure: The substance is mildly irritating to the eyes and respiratory tract, may cause effects on the central nervous system, blood, bone marrow, kidneys and liver. Exposure at high levels could cause unconsciousness. Long-term or repeated exposure: The liquid defats the skin, may have effects on the blood and bone marrow. The major long-term effects of exposure for humans are developmental, testicular, and hematological toxicity. A cross-sectional evaluation of semen quality was carried out in workers exposed to EGEE. A control group of workers from the same plant was included. Workers exposed to EGEE had significantly lower average sperm counts than controls, although both groups had lower sperm counts than those found in other occupational groups. In other study, hemoglobin, hematocrit, red cell indices, total and differential white blood cell counts, and platelet count were measured in shipyard painters and control subjects as part of a cross-sectional, observational study of the effects of ethylene glycol ethers. A significant proportion of painters were anemic (10%) and granulocytopenic (5%)none of the controls were affected. ANIMAL TOXICITY STUDIES: EGEE administered sc for 4 weeks at doses of up to 0.38 g/kg/day caused no deaths in rats. Dose levels of 0.185 and 0.38 g/kg caused dyspnea, somnolence, mild ataxia, some growth depression in females, and reduction of hemoglobin levels and hematocrit values. At the 0.38 g/kg level interstitial testicular edema, dissociation of liver parenchyma and tubular lesions of the kidney were observed. The effects of EGEE on testicular cell populations in puber |
| Ökotoxizitätsauszüge | /AQUATIC SPECIES/ The acute toxicity of /2-Ethoxyethanol/ (2-EE) is very low for ... freshwater fish (LC50 > 10 g/L)./OTHER TERRESTRIAL SPECIES/ The acute toxicity of /2-Ethoxyethanol/ (2-EE) is very low for arthropods (LC50 > 4 g/L). |
| Signs and Symptoms | Cough. Drowsiness. Headache. Shortness of breath. Sore throat.MAY BE ABSORBED! Further see Inhalation.Redness. Pain.Abdominal pain. Nausea. Vomiting. Further see Inhalation.In Animals: irritation eyes, respiratory systemblood changesliver, kidney, lung damagereproductive, teratogenic effects |
| Ongoing Test Status | EPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assaysSee the data in Chemical Explorer/[USEPAICSS Dashboard ApplicationAvailable from, as of June 27, 2014: http://actor.epa.gov/dashboard/]The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of June 30, 2014: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=110-80-5] |
| Effluent Concentrations | Ethylene glycol monoethyl ether was detected in active compost blower exhaust at 9 ug/cu m(1). |
| RCRA-Anforderungen | U359As stipulated in 40 CFR 261.33, when ethylene glycol monoethyl ether, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).F005When 2-ethoxyethanol is a spent non-halogenated solvent, it is classified as a hazardous waste from a nonspecific source (F005), as stated in 40 CFR 261.31, and must be managed according to State and/or Federal hazardous waste regulations. |
| Luftstandards | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylene glycol monoethyl ether is produced, as an intermediate or a final product, by process units covered under this subpart. |
| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| Landesrichtlinien für Trinkwasser | (FL) FLORIDA 25,000 ug/L |
| Berufliche Expositionsstufe (OEB) | B |
| Arbeitsplatzgrenzwert (OEL) | TWA: 0.5 ppm (1.8 mg/m3) [skin] |
| Wassergefährdungsklasse (WGK) | 1 |
| Sofort lebensgefährliche Konzentration | 500 ppm |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 1171 |
| Zollcode | 29094990 |
| RTECS-Nr. | KK8050000 |
| R-Sätze (R) | 60-61-10-20/21/22-20/22 |
| Toxizität | Acute oral LD50 for guinea pigs 1,400 mg/kg, mice 2,451 mg/kg, rats 3,000 mg/kg, rabbits 3,100 mg/kg (quoted, RTECS, 1985). |
| Gefahrensymbole | T |
| Sicherheitshinweise (S) | 53-45 |
| Gefahrenklasse | 3Acute Tox. 3 InhalationAcute Tox. 4 OralFlam. Liq. 3Repr. 1B |
| Verpackungsgruppe | III |
| Lagerklasse | 3 - Flammable liquids |
| Gefahrstoffdaten | 110-80-5(Hazardous Substances Data) |
| Selbstentzündungstemperatur | 460 °F |
Anwendungen & Verwendung
Beschreibung
2-Ethoxyethanol is a stable, colorless, flammable liquid, synthetically produced throughout the world. It belongs to a larger group of glycol ether solvents. 2-Ethoxyethanol is commercially referred to as Ethyl Cellosolve or Cellosolve, a trademark registered by Union Carbide in 1924. It was first synthesized to have the same chemical properties of both alcohols and ethers (hydrophilic and lipophilic) but less volatile, which improves production characteristics. The glycol ethers are made by reacting anhydrous alcohols with ethylene oxide.
Verwenden
2-Ethoxyethanol is widely used as an industrial solvent and production intermediate. It is produced by the reaction of ethylene oxide with ethanol. The glycol ethers are miscible in polar and nonpolar solutions, which make them useful solvents in paints and surface coatings, stains, lacquers, inks, and dyes. Additional uses include industrial deicing, hydraulic fluids, and cleaning agents. 2-Ethoxyethanol was once used in cosmetic products but is no longer used due to toxicity associated with dermal absorption. Global production has been on the decline in recent years based on demonstrated toxicity through oral, dermal, and inhalation routes of exposure. The use of ethylene glycol ethers has largely been replaced by relatively safer substitutes, primarily propylene glycol ethers; however, their use as a solvent and chemical process intermediate poses potential for release into the environment.